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protein coding gene - iph1 (SPACUNK4.12c) - mitochondrial matrix endopeptidase

Gene summary

Standard name
iph1
Systematic ID
SPACUNK4.12c
Product
mitochondrial matrix endopeptidase
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
mug138, irp1, ppp34
UniProt ID
O14077
ORFeome ID
47/47D09
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 2886940..2890095 forward strand

Annotation

Disease association

MONDO:0100087 - familial Alzheimer disease

References:

MONDO:0005071 - nervous system disorder

References:

GO biological process

GO:0034982 - mitochondrial protein processing

References:

GO:0043171 - peptide catabolic process

References:

GO:0030163 - protein catabolic process

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GO cellular component

GO:0005829 - cytosol

References:

GO:0005739 - mitochondrion

References:

GO molecular function

GO:0046872 - metal ion binding

References:

GO:0004222 - metalloendopeptidase activity

References:

Multi-locus phenotype

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

References:

PomGeneEx:0000011 - RNA level increased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0001147 - normal mating efficiency

References:

Genotypes:

FYPO:0001986 - resistance to 5-fluorouracil

References:

Genotypes:

FYPO:0000073 - resistance to caffeine

References:

Genotypes:

FYPO:0002693 - resistance to diamide

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Genotypes:

FYPO:0009038 - resistance to egtazic acid

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Genotypes:

FYPO:0001453 - resistance to ethanol

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Genotypes:

FYPO:0005253 - resistance to tamoxifen

References:

Genotypes:

FYPO:0001034 - resistance to tunicamycin

References:

Genotypes:

FYPO:0009088 - sensitive to magnesium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0007924 - sensitive to potassium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0003656 - sensitive to vanadate

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

Protein features

IDNameInterPro nameDB name
PF00675Peptidase_M16Pept_M16_NPfam
PF05193Peptidase_M16_CPeptidase_M16_CPfam
PF16187Peptidase_M16_MPeptidase_M16_MPfam
PF22456PqqF-like_C_4PqqF-like_C_4Pfam
PS00143INSULINASEPept_M16_Zn_BSPROSITE patterns
G3DSA:3.30.830.10:FF:000003CATH-FunFam
G3DSA:3.30.830.10:FF:000004CATH-FunFam
G3DSA:3.30.830.10:FF:000005CATH-FunFam
G3DSA:3.30.830.10:FF:000066CATH-FunFam
G3DSA:3.30.830.10CATH-Gene3D
SSF63411Metalloenz_LuxS/M16SUPERFAMILY
PTHR43690Peptidase_M16PANTHER
CoilCOILS

Orthologs

References / Literature

PMID:14517947 - Genetic variation in a haplotype block spanning IDE influences Alzheimer disease.
Prince JA et al. Hum Mutat 2003 Nov;22(5):363-71
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
GO_REF:0000002 - Comments
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:23826334 - Deletion of the fission yeast homologue of human insulinase reveals a TORC1-dependent pathway mediating resistance to proteotoxic stress.
Beuzelin C et al. PLoS One 2013;8(6):e67705
PMID:16491466 - Construction of a protease-deficient strain set for the fission yeast Schizosaccharomyces pombe, useful for effective production of protease-sensitive heterologous proteins.
Idiris A et al. Yeast 2006 Jan 30;23(2):83-99
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:26628015 - Characterization of Tamoxifen as an Antifungal Agent Using the Yeast Schizosaccharomyces Pombe Model Organism.
Zhang X et al. Kobe J Med Sci 2015 Oct 09;61(2):E54-63
PMID:24192486 - The conserved Fanconi anemia nuclease Fan1 and the SUMO E3 ligase Pli1 act in two novel Pso2-independent pathways of DNA interstrand crosslink repair in yeast.
Fontebasso Y et al. DNA Repair (Amst) 2013 Dec;12(12):1011-23
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:27255861 - Genetic evidence for involvement of membrane trafficking in the action of 5-fluorouracil.
Hu L et al. Fungal Genet Biol 2016 Aug;93:17-24
GO_REF:0000051 - S. pombe keyword mapping
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.
Mata J et al. Nat Genet 2002 Sep;32(1):143-7
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:9450053 - N-terminal processing of the M-factor mating pheromone in fission yeast.
Hughes M et al. Biochem Soc Trans 1997 Nov;25(4):S625
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:28945192 - Regulated Ire1-dependent mRNA decay requires no-go mRNA degradation to maintain endoplasmic reticulum homeostasis in S. pombe .
Guydosh NR et al. Elife 2017 Sep 25;6
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36