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protein coding gene - ola2 (SPACUNK4.13c) - Obg-like ATPase, human OLA1 ortholog, Ola2

Gene summary

Standard name
ola2
Systematic ID
SPACUNK4.13c
Product
Obg-like ATPase, human OLA1 ortholog, Ola2
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O14078
ORFeome ID
21/21D04
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome I: 2885176..2886782 forward strand

Annotation

GO biological process

GO:2000765 - regulation of cytoplasmic translation

References:

GO cellular component

GO:0005737 - cytoplasm

References:

GO molecular function

GO:0005524 - ATP binding

References:

GO:0016887 - ATP hydrolysis activity

References:

GO:0005525 - GTP binding

References:

Protein features

PBO:0111827 - GTP1/OBG family

Quantitative gene expression

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0009007 - decreased vegetative cell population viability

References:

Genotypes:

FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0009086 - sensitive to lithium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0000797 - sensitive to tert-butyl hydroperoxide

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

Protein features

IDNameInterPro nameDB name
PF06071YchF-GTPase_CYchF_CPFAM
PF01926MMR_HSR1GTP-bdPFAM
cd04867TGS_YchF_OLA1YchF_CCDD
cd01900YchFYchF_NCDD
PS51880TGSTGSPROSITE_PROFILES
PS51710G_OBGG_OBGPROSITE_PROFILES
PR00326GTP1OBGGTP-bdPRINTS
G3DSA:1.10.150.300:FF:000001FUNFAM
G3DSA:3.10.20.30:FF:000001FUNFAM
SSF81271TGS-likeTGS-likeSUPERFAMILY
SSF52540P-loop containing nucleoside triphosphate hydrolasesP-loop_NTPaseSUPERFAMILY
G3DSA:3.40.50.300P-loop_NTPaseGENE3D
G3DSA:1.10.150.300TGS-like_dom_sfGENE3D
G3DSA:3.10.20.30Beta-grasp_dom_sfGENE3D
PTHR23305OBG GTPASE FAMILYPANTHER
PIRSF006641EngDATPase_YchF/OLA1PIRSF
TIGR00092TIGR00092ATPase_YchF/OLA1NCBIFAM

Orthologs

References / Literature

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:39934121 - Conserved GTPase OLA1 promotes efficient translation on D/E-rich mRNA.
Yu T et al. Nat Commun 2025 Feb 11;16(1):1549
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
GO_REF:0000002 - Comments
PMID:32435206 - Posttranslational Arginylation Enzyme Arginyltransferase1 Shows Genetic Interactions With Specific Cellular Pathways in vivo .
Wiley DJ et al. Front Physiol 2020;11:427
PMID:34984977 - Functional profiling of long intergenic non-coding RNAs in fission yeast.
Rodriguez-Lopez M et al. Elife 2022 Jan 05;11
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12