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protein coding gene - tad3 (SPAP27G11.04c) - tRNA specific adenosine-34 deaminase subunit Tad3

Gene summary

Standard name
tad3
Systematic ID
SPAP27G11.04c
Product
tRNA specific adenosine-34 deaminase subunit Tad3
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q9P7N4
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 1614241..1615504 reverse strand

Annotation

Disease association

MONDO:0014119 - intellectual disability-strabismus syndrome

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GO biological process

GO:0002100 - tRNA wobble adenosine to inosine editing

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GO cellular component

GO:0005737 - cytoplasm

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GO:0005829 - cytosol

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GO:0005634 - nucleus

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GO:0052718 - tRNA-specific adenosine-34 deaminase complex

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GO molecular function

GO:0030234 - enzyme regulator activity

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GO:0052717 - tRNA-specific adenosine-34 deaminase activity

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Modification

MOD:00046 - O-phospho-L-serine

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Qualitative gene expression

PomGeneEx:0000012 - RNA level decreased

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Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000400 - abnormal cell cycle arrest at mitotic G2/M phase transition

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Genotypes:

FYPO:0005097 - abnormal cell cycle arrest in mitotic G1 phase

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Genotypes:

FYPO:0004481 - abolished cell population growth at high temperature

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Genotypes:

FYPO:0001838 - decreased protein phosphorylation during vegetative growth

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Genotypes:

FYPO:0000951 - inviable small vegetative cell

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

FYPO:0003031 - mating without nitrogen starvation

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Genotypes:

FYPO:0001357 - normal vegetative cell population growth

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Genotypes:

FYPO:0000104 - sensitive to cycloheximide

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Genotypes:

Subunit composition

PBO:0015221 - heteromeric(2)

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF00383dCMP_cyt_deam_1CMP_dCMP_domPfam
PF30953TAD3_NTAD3_NPfam
cd01285nucleoside_deaminaseCDD
PS51747CYT_DCMP_DEAMINASES_2CMP_dCMP_domPROSITE profiles
G3DSA:3.40.140.10CATH-Gene3D
SSF53927Cytidine_deaminase-likeSUPERFAMILY
PTHR11079PANTHER

Orthologs

References / Literature

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:34194665 - Functional and structural investigation of N-terminal domain of the SpTad2/3 heterodimeric tRNA deaminase.
Liu X et al. Comput Struct Biotechnol J 2021;19:3384-3393
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:17875641 - Wobble inosine tRNA modification is essential to cell cycle progression in G(1)/S and G(2)/M transitions in fission yeast.
Tsutsumi S et al. J Biol Chem 2007 Nov 16;282(46):33459-33465
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:26842963 - ADAT3-related intellectual disability: Further delineation of the phenotype.
El-Hattab AW et al. Am J Med Genet A 2016 May;170A(5):1142-7
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:29330317 - tRNA production links nutrient conditions to the onset of sexual differentiation through the TORC1 pathway.
Otsubo Y et al. EMBO Rep 2018 Mar;19(3)
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053