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protein coding gene - nup184 (SPAP27G11.10c) - nucleoporin Nup184

Gene summary

Standard name
nup184
Systematic ID
SPAP27G11.10c
Product
nucleoporin Nup184
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q9P7M8
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 1624751..1629947 reverse strand

Annotation

Disease association

MONDO:0032926 - sandestig-stefanova syndrome

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GO biological process

GO:0006406 - mRNA export from nucleus

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GO:0006607 - NLS-bearing protein import into nucleus

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GO:0006611 - protein export from nucleus

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GO cellular component

GO:0005643 - nuclear pore

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GO:0044611 - nuclear pore inner ring

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GO molecular function

GO:0017056 - structural constituent of nuclear pore

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Modification

MOD:00046 - O-phospho-L-serine

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Multi-locus phenotype

FYPO:0002522 - decreased poly(A)+ mRNA export from nucleus

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

FYPO:0003027 - normal poly(A)+ mRNA export from nucleus

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000059 - abnormal mitotic cell cycle

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Genotypes:

FYPO:0000708 - decreased mating efficiency

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Genotypes:

FYPO:0001324 - decreased protein level during vegetative growth

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Genotypes:

FYPO:0000581 - decreased spore germination frequency

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Genotypes:

FYPO:0001355 - decreased vegetative cell population growth

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Genotypes:

FYPO:0001122 - elongated vegetative cell

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Genotypes:

FYPO:0009094 - increased cell population growth on lysine and proline nitrogen source

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Genotypes:

FYPO:0009093 - increased cell population growth on lysine and serine nitrogen source

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Genotypes:

FYPO:0009072 - increased cell population growth on lysine nitrogen source

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Genotypes:

FYPO:0004295 - multiseptate cell

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Genotypes:

FYPO:0009031 - resistance to bleomycin

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Genotypes:

FYPO:0000067 - resistance to brefeldin A

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Genotypes:

FYPO:0000763 - resistance to cadmium

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Genotypes:

FYPO:0000073 - resistance to caffeine

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Genotypes:

FYPO:0000725 - resistance to methyl methanesulfonate

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Genotypes:

FYPO:0003383 - resistance to tert-butyl hydroperoxide

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Genotypes:

FYPO:0009060 - resistance to wortmannin

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Genotypes:

FYPO:0006930 - sensitive to butylated hydroxyanisole

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Genotypes:

FYPO:0000104 - sensitive to cycloheximide

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Genotypes:

FYPO:0000799 - sensitive to diamide

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Genotypes:

FYPO:0007931 - sensitive to egtazic acid

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Genotypes:

FYPO:0001719 - sensitive to lithium

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Genotypes:

FYPO:0009086 - sensitive to lithium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0001492 - viable elongated vegetative cell

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002104 - viable vegetative cell with normal cell shape

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Warnings

PBO:0000108 - frameshifted

References:

PBO:0091338 - I:g.1625092_1625093insC

References:

PBO:0000129 - sequence error in genomic data

References:

Protein features

IDNameInterPro nameDB name
PF18378Nup188_CNup188_CPfam
PF21093Nup188_N-subdom_IIINup188_N-subdom_IIIPfam
G3DSA:1.25.10.70CATH-Gene3D
PTHR31431Nup188PANTHER

Orthologs

References / Literature

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:30647105 - Comparative Genomic Screen in Two Yeasts Reveals Conserved Pathways in the Response Network to Phenol Stress.
Alhoch B et al. G3 (Bethesda) 2019 Mar 07;9(3):639-650
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:20970342 - Virtual breakdown of the nuclear envelope in fission yeast meiosis.
Asakawa H et al. Curr Biol 2010 Nov 09;20(21):1919-25
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:11073978 - Mex67p of Schizosaccharomyces pombe interacts with Rae1p in mediating mRNA export.
Yoon JH et al. Mol Cell Biol 2000 Dec;20(23):8767-82
PMID:27736299 - A genome-wide screen to identify genes controlling the rate of entry into mitosis in fission yeast.
Moris N et al. Cell Cycle 2016 Nov 16;15(22):3121-3130
PMID:10388805 - Regulation of mRNA export by nutritional status in fission yeast.
Whalen WA et al. Genetics 1999 Jul;152(3):827-38
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:31657618 - A Genome-Wide Screen for Wortmannin-Resistant Mutants in Schizosaccharomyces pombe: The Phosphorylation-Impaired Mutants Are Resistant to Signaling Defect.
Yılmazer M et al. DNA Cell Biol 2019 Dec;38(12):1427-1436
PMID:12181330 - Crp79p, like Mex67p, is an auxiliary mRNA export factor in Schizosaccharomyces pombe.
Thakurta AG et al. Mol Biol Cell 2002 Aug;13(8):2571-84
PMID:12112233 - Schizosaccharomyces pombe spPABP, a homologue of Saccharomyces cerevisiae Pab1p, is a non-essential, shuttling protein that facilitates mRNA export.
Thakurta AG et al. Yeast 2002 Jun 30;19(9):803-10
PMID:28410370 - A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.
Dudin O et al. PLoS Genet 2017 Apr;13(4):e1006721
PMID:26615217 - Bulk Segregant Analysis Reveals the Genetic Basis of a Natural Trait Variation in Fission Yeast.
Hu W et al. Genome Biol Evol 2015 Nov 27;7(12):3496-510
PMID:34010011 - Heh2/Man1 may be an evolutionarily conserved sensor of NPC assembly state.
Borah S et al. Mol Biol Cell 2021 Jul 15;32(15):1359-1373
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:32049412 - Human Ebp1 rescues the synthetic lethal growth of fission yeast cells lacking Cdb4 and Nup184.
Osemwenkhae OP et al. Genes Cells 2020 Apr;25(4):288-295
PMID:12110682 - Elf1p, a member of the ABC class of ATPases, functions as a mRNA export factor in Schizosacchromyces pombe.
Kozak L et al. J Biol Chem 2002 Sep 13;277(37):33580-9
PMID:24637836 - Characterization of nuclear pore complex components in fission yeast Schizosaccharomyces pombe.
Asakawa H et al. Nucleus 2014;5(2):149-62
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7