protein coding gene - slx1 (SPAP27G11.15) - structure-specific endonuclease catalytic subunit Slx1

Gene summary

Standard name

slx1

Systematic ID

SPAP27G11.15

Product

structure-specific endonuclease catalytic subunit Slx1

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

Q9P7M3

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 1638307..1641062 forward strand

Annotation

Protein features

Orthologs

• SLX1A (HGNC:20922) Homo sapiens
• SLX1B (HGNC:28748) Homo sapiens
• slx1 (SJAG_05237) Schizosaccharomyces japonicus
• SLX1 (YBR228W) Saccharomyces cerevisiae

References / Literature

PMID:16467377 - Rad22Rad52-dependent repair of ribosomal DNA repeats cleaved by Slx1-Slx4 endonuclease.

Coulon S et al. Mol Biol Cell 2006 Apr;17(4):2081-90

PMID:29898918 - Mutations that prevent methylation of cohesin render sensitivity to DNA damage in S. pombe .

Sanyal S et al. J Cell Sci 2018 Jul 06;131(13)

PMID:17178839 - Fission yeast Cut8 is required for the repair of DNA double-strand breaks, ribosomal DNA maintenance, and cell survival in the absence of Rqh1 helicase.

Kearsey SE et al. Mol Cell Biol 2007 Mar;27(5):1558-67

PMID:15972456 - Brc1-mediated DNA repair and damage tolerance.

Sheedy DM et al. Genetics 2005 Oct;171(2):457-68

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:29259000 - Genes Important for Schizosaccharomyces pombe Meiosis Identified Through a Functional Genomics Screen.

Blyth J et al. Genetics 2018 Feb;208(2):589-603

PMID:33260998 - High-Throughput Flow Cytometry Combined with Genetic Analysis Brings New Insights into the Understanding of Chromatin Regulation of Cellular Quiescence.

Zahedi Y et al. Int J Mol Sci 2020 Nov 27;21(23)

PMID:20625380 - A genome-wide screen for Schizosaccharomyces pombe deletion mutants that affect telomere length.

Liu NN et al. Cell Res 2010 Aug;20(8):963-5

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

GO_REF:0000043 - Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping

PMID:16710300 - Sws1 is a conserved regulator of homologous recombination in eukaryotic cells.

Martín V et al. EMBO J 2006 Jun 07;25(11):2564-74

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:18818364 - Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast.

Roguev A et al. Science 2008 Oct 17;322(5900):405-10

PMID:26787556 - Crystal structure and SUMO binding of Slx1-Slx4 complex.

Lian FM et al. Sci Rep 2016 Jan 20;6:19331

GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:14528010 - Slx1-Slx4 are subunits of a structure-specific endonuclease that maintains ribosomal DNA in fission yeast.

Coulon S et al. Mol Biol Cell 2004 Jan;15(1):71-80