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protein coding gene - emc5 (SPAP4C9.02) - ER membrane protein complex subunit Emc5

Gene summary

Standard name
emc5
Systematic ID
SPAP4C9.02
Product
ER membrane protein complex subunit Emc5
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
SPNG750-51, SPNCRNA.235
UniProt ID
C6Y4A7
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 3790924..3791756 forward strand

Annotation

GO biological process

GO:0045048 - protein insertion into ER membrane

References:

GO cellular component

GO:0072546 - EMC complex

References:

GO:0005789 - endoplasmic reticulum membrane

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:00047 - O-phospho-L-threonine

References:

Protein sequence feature

SO:0001812 - transmembrane_helix

References:

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

References:

Quantitative gene expression

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000080 - decreased cell population growth at low temperature

References:

Genotypes:

FYPO:0000095 - sensitive to bleomycin

References:

Genotypes:

FYPO:0001188 - sensitive to Calcofluor White

References:

Genotypes:

FYPO:0001491 - viable vegetative cell

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Warnings

PBO:0000082 - new gene

References:

PBO:0000406 - previously annotated as ncRNA

Protein features

IDNameInterPro nameDB name
PF10270MMgTMMgTPfam
Transmembrane alpha helixDeepTMHMM

Orthologs

References / Literature

GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:40124504 - Ltc1 localization by EMC regulates cell membrane fluidity to facilitate membrane protein biogenesis.
Berraquero M et al. iScience 2025 Mar 21;28(3):112096
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:18488015 - Dynamic repertoire of a eukaryotic transcriptome surveyed at single-nucleotide resolution.
Wilhelm BT et al. Nature 2008 Jun 26;453(7199):1239-43
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:22907753 - Posttranscriptional regulation of cell-cell interaction protein-encoding transcripts by Zfs1p in Schizosaccharomyces pombe.
Wells ML et al. Mol Cell Biol 2012 Oct;32(20):4206-14
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:24013502 - Epe1 recruits BET family bromodomain protein Bdf2 to establish heterochromatin boundaries.
Wang J et al. Genes Dev 2013 Sep 01;27(17):1886-902
PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:26438724 - H3K9 methylation extends across natural boundaries of heterochromatin in the absence of an HP1 protein.
Stunnenberg R et al. EMBO J 2015 Nov 12;34(22):2789-803
PMID:27168121 - Discovery of genes involved in mitosis, cell division, cell wall integrity and chromosome segregation through construction of Schizosaccharomyces pombe deletion strains.
Chen JS et al. Yeast 2016 Sep;33(9):507-17