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protein coding gene - gua2 (SPAP7G5.02c) - GMP synthase [glutamine-hydrolyzing] Gua2

Gene summary

Standard name
gua2
Systematic ID
SPAP7G5.02c
Product
GMP synthase [glutamine-hydrolyzing] Gua2
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q9P772
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome I: 3733592..3735713 reverse strand

Annotation

GO biological process

GO:0032263 - GMP salvage

References:

GO cellular component

GO:0005829 - cytosol

References:

GO molecular function

GO:0005524 - ATP binding

References:

GO:0003921 - GMP synthase activity

References:

Modification

MOD:00047 - O-phospho-L-threonine

References:

MOD:01148 - ubiquitinylated lysine

References:

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

References:

PomGeneEx:0000027 - ribosomal density decreased

References:

PomGeneEx:0000012 - RNA level decreased

References:

PomGeneEx:0000011 - RNA level increased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000311 - inviable after spore germination with normal, unseptated germ tube morphology

References:

Genotypes:

FYPO:0002151 - inviable spore

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Warnings

PBO:0000912 - inferred from genetic map position

Protein features

IDNameInterPro nameDB name
PF00958GMP_synt_CGMP_synth_CPFAM
PF00117GATaseGATASEPFAM
cd01997GMP_synthase_CGMP_synth_CCDD
cd01742GATase1_GMP_SynthaseGMP_synth_GATaseCDD
PS51553GMPS_ATP_PPASEGMPS_ATP_PPase_domPROSITE_PROFILES
PS51273GATASE_TYPE_1PROSITE_PROFILES
PR00097ANTSNTHASEIIPRINTS
PR00096GATASEPRINTS
G3DSA:3.40.50.620:FF:000001FUNFAM
G3DSA:3.40.50.880:FF:000001FUNFAM
G3DSA:3.30.300.10:FF:000002FUNFAM
SSF52317Class I glutamine amidotransferase-likeClass_I_gatase-likeSUPERFAMILY
SSF54810GMP synthetase C-terminal dimerisation domainSUPERFAMILY
SSF52402Adenine nucleotide alpha hydrolases-likeSUPERFAMILY
G3DSA:3.30.300.10GENE3D
G3DSA:3.40.50.620HUPsRossmann-like_a/b/a_foldGENE3D
G3DSA:3.40.50.880Class_I_gatase-likeGENE3D
PTHR11922GMP SYNTHASE-RELATEDPANTHER
MF_00344GMP_synthaseGMP_synthaseHAMAP
TIGR00884guaA_CtermGMP_synth_CNCBIFAM
TIGR00888guaA_NtermGMP_synth_GATaseNCBIFAM
NF000848PRK00074.1NCBIFAM

Orthologs

References / Literature

GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:36478272 - Translation-complex profiling of fission yeast cells reveals dynamic rearrangements of scanning ribosomal subunits upon nutritional stress.
Duncan CDS et al. Nucleic Acids Res 2022 Dec 09;50(22):13011-13025
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.
Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684
PMID:23163955 - Analysis of stress-induced duplex destabilization (SIDD) properties of replication origins, genes and intergenes in the fission yeast, Schizosaccharomyces pombe.
Yadav MP et al. BMC Res Notes 2012 Nov 19;5:643
GO_REF:0000002 - Comments
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.
Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.
Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:31064814 - Proximity-dependent biotinylation mediated by TurboID to identify protein-protein interaction networks in yeast.
Larochelle M et al. J Cell Sci 2019 May 31;132(11)
PMID:22730331 - Dual recruitment of Cdc48 (p97)-Ufd1-Npl4 ubiquitin-selective segregase by small ubiquitin-like modifier protein (SUMO) and ubiquitin in SUMO-targeted ubiquitin ligase-mediated genome stability functions.
Nie M et al. J Biol Chem 2012 Aug 24;287(35):29610-9
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105