protein coding gene - per1 (SPAP7G5.06) - plasma membrane amino acid transmembrane transporter Per1

Gene summary

Standard name

per1

Systematic ID

SPAP7G5.06

Product

plasma membrane amino acid transmembrane transporter Per1

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

Q9P768

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 3749441..3751729 forward strand

Annotation

Protein features

Orthologs

• SLC7A1 (HGNC:11057) Homo sapiens
• SLC7A2 (HGNC:11060) Homo sapiens
• SLC7A3 (HGNC:11061) Homo sapiens
• SLC7A4 (HGNC:11062) Homo sapiens
• SLC7A14 (HGNC:29326) Homo sapiens
• SJAG_04637 Schizosaccharomyces japonicus
• BAP2 (YBR068C) Saccharomyces cerevisiae
• TAT1 (YBR069C) Saccharomyces cerevisiae
• AGP1 (YCL025C) Saccharomyces cerevisiae
• BAP3 (YDR046C) Saccharomyces cerevisiae
• GNP1 (YDR508C) Saccharomyces cerevisiae
• HIP1 (YGR191W) Saccharomyces cerevisiae
• GAP1 (YKR039W) Saccharomyces cerevisiae
• LYP1 (YNL268W) Saccharomyces cerevisiae
• ALP1 (YNL270C) Saccharomyces cerevisiae
• TAT2 (YOL020W) Saccharomyces cerevisiae

References / Literature

PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.

Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:32896087 - Mitochondrial respiration is required to provide amino acids during fermentative proliferation of fission yeast.

Malecki M et al. EMBO Rep 2020 Nov 05;21(11):e50845

PMID:17179073 - Opposite effects of tor1 and tor2 on nitrogen starvation responses in fission yeast.

Weisman R et al. Genetics 2007 Mar;175(3):1153-62

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.

Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80

GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.

PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.

Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.

UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531

PMID:36481249 - Critical role of Wat1/Pop3 in regulating the TORC1 signalling pathway in fission yeast S. pombe.

Panigrahi L et al. Fungal Genet Biol 2023 Jan;164:103764

PMID:15466417 - Regulation of leucine uptake by tor1+ in Schizosaccharomyces pombe is sensitive to rapamycin.

Weisman R et al. Genetics 2005 Feb;169(2):539-50

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:17556368 - The Birt-Hogg-Dube and tuberous sclerosis complex homologs have opposing roles in amino acid homeostasis in Schizosaccharomyces pombe.

van Slegtenhorst M et al. J Biol Chem 2007 Aug 24;282(34):24583-90

PMID:31626996 - Multiplexed proteome profiling of carbon source perturbations in two yeast species with SL-SP3-TMT.

Paulo JA et al. J Proteomics 2020 Jan 06;210:103531

PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.

Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:23163955 - Analysis of stress-induced duplex destabilization (SIDD) properties of replication origins, genes and intergenes in the fission yeast, Schizosaccharomyces pombe.

Yadav MP et al. BMC Res Notes 2012 Nov 19;5:643

PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.

Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6

PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.

Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684

PMID:20404084 - Transcriptional activation of the general amino acid permease gene per1 by the histone deacetylase Clr6 Is regulated by Oca2 kinase.

Kaufmann I et al. Mol Cell Biol 2010 Jul;30(13):3396-410

PMID:24344203 - Isp7 is a novel regulator of amino acid uptake in the TOR signaling pathway.

Laor D et al. Mol Cell Biol 2014 Mar;34(5):794-806

PMID:34805795 - The fission yeast FLCN/FNIP complex augments TORC1 repression or activation in response to amino acid (AA) availability.

Calvo IA et al. iScience 2021 Nov 19;24(11):103338

PMID:34296454 - The TOR-dependent phosphoproteome and regulation of cellular protein synthesis.

Mak T et al. EMBO J 2021 Aug 16;40(16):e107911

PMID:38780300 - Nitrogen availability is important for preventing catastrophic mitosis in fission yeast.

Zemlianski V et al. J Cell Sci 2024 May 23;

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.

Strachan J et al. J Cell Sci 2023 Dec 01;136(23)

PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.

Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:36478272 - Translation-complex profiling of fission yeast cells reveals dynamic rearrangements of scanning ribosomal subunits upon nutritional stress.

Duncan CDS et al. Nucleic Acids Res 2022 Dec 09;50(22):13011-13025