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protein coding gene - paa1 (SPAP8A3.09c) - serine/threonine protein phosphatase PP2A scaffold subunit Paa1

Gene summary

Standard name
paa1
Systematic ID
SPAP8A3.09c
Product
serine/threonine protein phosphatase PP2A scaffold subunit Paa1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q9UT08
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 5330096..5332739 reverse strand

Annotation

Disease association

MONDO:0014605 - Houge-Janssens syndrome 2

References:

MONDO:0008903 - lung cancer

References:

GO biological process

GO:0030952 - establishment or maintenance of cytoskeleton polarity

References:

GO:1990813 - meiotic centromeric cohesion protection in anaphase I

References:

GO:0031030 - negative regulation of septation initiation signaling

References:

GO:0051225 - spindle assembly

References:

GO cellular component

GO:0000775 - chromosome, centromeric region

References:

GO:0005829 - cytosol

References:

GO:0090443 - FAR/SIP/STRIPAK complex

References:

GO:0110085 - mitotic actomyosin contractile ring

References:

GO:0044732 - mitotic spindle pole body

References:

GO:0005634 - nucleus

References:

GO:0000159 - protein phosphatase type 2A complex

References:

GO molecular function

GO:0140378 - protein complex scaffold activity

References:

GO:0019888 - protein phosphatase regulator activity

References:

Multi-locus phenotype

FYPO:0005727 - decreased rate of deactivation of mitotic spindle assembly checkpoint

References:

Genotypes:

FYPO:0005728 - normal deactivation of mitotic spindle assembly checkpoint

References:

Genotypes:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0001876 - decreased asymmetric protein localization, with protein localized to both mitotic spindle pole bodies during anaphase

References:

Genotypes:

FYPO:0002021 - dispersed actin cortical patch localization during vegetative growth

References:

Genotypes:

FYPO:0001758 - increased protein phosphatase activity

References:

Genotypes:

FYPO:0002762 - inviable after spore germination, without cell division, spheroid cell

References:

Genotypes:

FYPO:0002151 - inviable spore

References:

Genotypes:

FYPO:0002191 - inviable swollen septated spheroid vegetative cell

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0002760 - short cytoplasmic microtubules

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

Protein features

IDNameInterPro nameDB name
PF02985HEATHEATPfam
PF22646PPP2R1A-like_HEATPP2A/SF3B1-like_HEATPfam
PF22956PIK3R4-like_middlePIK3R4-like_middlePfam
PS50077HEAT_REPEATHEAT_type_2PROSITE profiles
G3DSA:1.25.10.10:FF:000011CATH-FunFam
G3DSA:1.25.10.10ARM-likeCATH-Gene3D
SSF48371ARM-type_foldSUPERFAMILY
PTHR10648PP2A_Regulatory_Subunit_APANTHER

Orthologs

References / Literature

PMID:31883795 - Positioning Heterochromatin at the Nuclear Periphery Suppresses Histone Turnover to Promote Epigenetic Inheritance.
Holla S et al. Cell 2020 Jan 09;180(1):150-164.e15
PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.
Lee J et al. Nat Commun 2017 Feb 20;8:14527
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:19371376 - Schizosaccharomyces pombe cell division cycle under limited glucose requires Ssp1 kinase, the putative CaMKK, and Sds23, a PP2A-related phosphatase inhibitor.
Hanyu Y et al. Genes Cells 2009 May;14(5):539-54
PMID:22403715 - Regulation of fission yeast morphogenesis by PP2A activator pta2.
Bernal M et al. PLoS One 2012;7(3):e32823
PMID:24634168 - Proteome-wide search for PP2A substrates in fission yeast.
Bernal M et al. Proteomics 2014 Jun;14(11):1367-80
PMID:36006032 - Analysis of the potential role of fission yeast PP2A in spindle assembly checkpoint inactivation.
Deng DJ et al. FASEB J 2022 Sep;36(9):e22524
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:16541024 - Protein phosphatase 2A protects centromeric sister chromatid cohesion during meiosis I.
Riedel CG et al. Nature 2006 May 04;441(7089):53-61
PMID:18204818 - Identification of small molecules inducing apoptosis by cell-based assay using fission yeast deletion mutants.
Chung KS et al. Invest New Drugs 2008 Aug;26(4):299-307
PMID:22119525 - SIN-inhibitory phosphatase complex promotes Cdc11p dephosphorylation and propagates SIN asymmetry in fission yeast.
Singh NS et al. Curr Biol 2011 Dec 06;21(23):1968-78
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:28947618 - Sde2 is an intron-specific pre-mRNA splicing regulator activated by ubiquitin-like processing.
Thakran P et al. EMBO J 2018 Jan 04;37(1):89-101
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:22730331 - Dual recruitment of Cdc48 (p97)-Ufd1-Npl4 ubiquitin-selective segregase by small ubiquitin-like modifier protein (SUMO) and ubiquitin in SUMO-targeted ubiquitin ligase-mediated genome stability functions.
Nie M et al. J Biol Chem 2012 Aug 24;287(35):29610-9
PMID:16541025 - Shugoshin collaborates with protein phosphatase 2A to protect cohesin.
Kitajima TS et al. Nature 2006 May 04;441(7089):46-52
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:24013502 - Epe1 recruits BET family bromodomain protein Bdf2 to establish heterochromatin boundaries.
Wang J et al. Genes Dev 2013 Sep 01;27(17):1886-902
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:9078365 - The regulatory subunits of fission yeast protein phosphatase 2A (PP2A) affect cell morphogenesis, cell wall synthesis and cytokinesis.
Kinoshita K et al. Genes Cells 1996 Jan;1(1):29-45