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protein coding gene - mtg2 (SPAP8A3.11c) - mitochondrial ribosome large subunit assembly GTPase Mtg2

Gene summary

Standard name
mtg2
Systematic ID
SPAP8A3.11c
Product
mitochondrial ribosome large subunit assembly GTPase Mtg2
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q9UT06
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome I: 5334899..5336408 reverse strand

Annotation

GO biological process

GO:1902775 - mitochondrial large ribosomal subunit assembly

References:

GO cellular component

GO:0005759 - mitochondrial matrix

References:

GO:0005739 - mitochondrion

References:

GO molecular function

GO:0005525 - GTP binding

References:

GO:0003924 - GTPase activity

References:

GO:0000287 - magnesium ion binding

References:

GO:0043022 - ribosome binding

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

Protein features

PBO:0111827 - GTP1/OBG family

Protein sequence feature

SO:0001808 - mitochondrial_targeting_signal

References:

Qualitative gene expression

PomGeneEx:0000012 - RNA level decreased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0002111 - inviable tapered vegetative cell

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF01018GTP1_OBGGTP1_OBG_domPfam
PF01926MMR_HSR1GTP-bdPfam
cd01898ObgG_OBGCDD
PS00905GTP1_OBGGTP1-OBG_CSPROSITE patterns
PS51710G_OBGG_OBGPROSITE profiles
PS51883OBGGTP1_OBG_domPROSITE profiles
PR00326GTP1OBGGTP-bdPRINTS
G3DSA:2.70.210.12:FF:000001CATH-FunFam
G3DSA:2.70.210.12GTP1_OBG_dom_sfCATH-Gene3D
G3DSA:3.40.50.300P-loop_NTPaseCATH-Gene3D
SSF52540P-loop_NTPaseSUPERFAMILY
SSF82051GTP1_OBG_dom_sfSUPERFAMILY
PTHR11702OBG_GTPasePANTHER
PIRSF002401GTP_bd_Obg/CgtAGTP-bd_Obg/CgtAPIRSF
NF008956obgENCBIFAM

Orthologs

References / Literature

PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
GO_REF:0000002 - Comments