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protein coding gene - pfl2 (SPAPB15E9.01c) - cell surface glycoprotein, flocculin Pfl2

Gene summary

Standard name
pfl2
Systematic ID
SPAPB15E9.01c
Product
cell surface glycoprotein, flocculin Pfl2
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
SPAPB18E9.06c
UniProt ID
Q8TFG9
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 3987033..3991412 reverse strand

Annotation

GO biological process

GO:0000128 - flocculation

References:

GO cellular component

GO:0070263 - external side of fungal-type cell wall

References:

GO:0009897 - external side of plasma membrane

References:

GO molecular function

GO:0098632 - cell-cell adhesion mediator activity

References:

Miscellaneous functional group

PBO:0000068 - cell surface glycoprotein

Modification

MOD:00818 - glycosylphosphatidylinositolated residue

References:

MOD:00006 - N-glycosylated residue

References:

MOD:00171 - N-seryl-glycosylphosphatidylinositolethanolamine

References:

Protein sequence feature

SO:0000418 - signal_peptide

References:

Qualitative gene expression

PomGeneEx:0000012 - RNA level decreased

References:

PomGeneEx:0000011 - RNA level increased

References:

Quantitative gene expression

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000155 - increased flocculation

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0016878 - Schizosaccharomyces pombe specific

Protein features

IDNameInterPro nameDB name
Signal PeptideDeepTMHMM-Signal-Peptide
mobidb-lite-Disorderdisorder_predictionMobiDB-Disorder
mobidb-lite-Low-complexitydisorder_predictionMobiDB-Low-complexity
mobidb-lite-Polardisorder_predictionMobiDB-Polar

References / Literature

PMID:12845604 - Genome-wide identification of fungal GPI proteins.
De Groot PW et al. Yeast 2003 Jul 15;20(9):781-96
PMID:20519959 - S. pombe genome deletion project: an update.
Spirek M et al. Cell Cycle 2010 Jun 15;9(12):2399-402
PMID:23231582 - Genome-wide characterization of the phosphate starvation response in Schizosaccharomyces pombe.
Carter-O'Connell I et al. BMC Genomics 2012 Dec 12;13:697
PMID:23236291 - Deciphering the transcriptional-regulatory network of flocculation in Schizosaccharomyces pombe.
Kwon EJ et al. PLoS Genet 2012;8(12):e1003104
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:38482739 - Critical importance of DNA binding for CSL protein functions in fission yeast.
Marešová A et al. J Cell Sci 2024 Mar 14;
PB_REF:0000007 - Prediction of GPI-anchored proteins with pointer neural networks
PMID:38269097 - Rapamycin-sensitive mechanisms confine the growth of fission yeast below the temperatures detrimental to cell physiology.
Morozumi Y et al. iScience 2024 Jan 19;27(1):108777
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.
Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
PMID:29214404 - The 19S proteasome regulates subtelomere silencing and facultative heterochromatin formation in fission yeast.
Seo HD et al. Curr Genet 2018 Jun;64(3):741-752
PMID:27886462 - Loss of ppr3, ppr4, ppr6, or ppr10 perturbs iron homeostasis and leads to apoptotic cell death in Schizosaccharomyces pombe.
Su Y et al. FEBS J 2017 Jan;284(2):324-337
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
GO_REF:0000050 - Manual transfer of GO annotation data to genes by curator judgment of sequence model
PMID:31276588 - Inositol pyrophosphates impact phosphate homeostasis via modulation of RNA 3' processing and transcription termination.
Sanchez AM et al. Nucleic Acids Res 2019 Sep 19;47(16):8452-8469
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399