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protein coding gene - sos7 (SPAPB17E12.06) - outer kinetochore KNL network protein Sos7

Gene summary

Standard name
sos7
Systematic ID
SPAPB17E12.06
Product
outer kinetochore KNL network protein Sos7
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
U3H042
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 1276494..1279000 forward strand

Annotation

Complementation

PBO:0011433 - functionally complemented by S. japonicus SJAG_03327

References:

GO biological process

GO:0051315 - attachment of mitotic spindle microtubules to kinetochore

References:

GO:0000070 - mitotic sister chromatid segregation

References:

GO:0051455 - spindle attachment to meiosis I kinetochore

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GO cellular component

GO:0000776 - kinetochore

References:

GO:0180019 - Knl1/Spc105 complex

References:

GO:0005634 - nucleus

References:

GO:0044732 - mitotic spindle pole body

References:

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0001269 - abolished protein localization to kinetochore during vegetative growth

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Genotypes:

FYPO:0001270 - complete but unequal mitotic sister chromatid segregation

References:

Genotypes:

FYPO:0001271 - incomplete, unequal mitotic sister chromatid segregation

References:

Genotypes:

FYPO:0001489 - inviable vegetative cell

References:

Genotypes:

FYPO:0001273 - mitotic spindle elongation with incomplete, unequal mitotic sister chromatid segregation and unseparated DNA

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

References:

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

References:

PBO:0011070 - conserved in vertebrates

References:

PBO:0006222 - predominantly single copy (one to one)

Warnings

PBO:0000070 - gene structure updated

References:

PBO:0000145 - previously annotated as pseudogene

Protein features

IDNameInterPro nameDB name
PF20882Sos7Sos7_CCPfam
PTHR37329Sos7PANTHER
CoilCOILS

Orthologs

References / Literature

GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:19893618 - Roles for the conserved spc105p/kre28p complex in kinetochore-microtubule binding and the spindle assembly checkpoint.
Pagliuca C et al. PLoS One 2009 Oct 28;4(10):e7640
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;
PMID:22711988 - Sos7, an essential component of the conserved Schizosaccharomyces pombe Ndc80-MIND-Spc7 complex, identifies a new family of fungal kinetochore proteins.
Jakopec V et al. Mol Cell Biol 2012 Aug;32(16):3308-20