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protein coding gene - sen2 (SPAPB17E12.07c) - tRNA-splicing endonuclease catalytic subunit Sen2

Gene summary

Standard name
sen2
Systematic ID
SPAPB17E12.07c
Product
tRNA-splicing endonuclease catalytic subunit Sen2
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q8TFH7
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome I: 1277120..1279110 reverse strand

Annotation

Disease association

MONDO:0012890 - pontocerebellar hypoplasia type 2B

References:

GO biological process

GO:0000379 - tRNA-type intron splice site recognition and cleavage

References:

GO cellular component

GO:0005737 - cytoplasm

References:

GO:0032473 - cytoplasmic side of mitochondrial outer membrane

References:

GO:0000214 - tRNA-intron endonuclease complex

References:

GO molecular function

GO:0000213 - tRNA-intron lyase activity

References:

Protein sequence feature

SO:0001812 - transmembrane_helix

References:

Qualitative gene expression

PomGeneEx:0000012 - RNA level decreased

References:

Quantitative gene expression

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0002187 - inviable normal volume spheroid vegetative cell

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF01974tRNA_int_endotRNA_intron_Endonuc_cat-likePFAM
cd22363tRNA-intron_lyase_CtRNA_intron_Endonuc_cat-likeCDD
G3DSA:3.40.1350.10:FF:000011FUNFAM
SSF53032tRNA-intron endonuclease catalytic domain-liketRNA_intron_Endo_cat-like_sfSUPERFAMILY
G3DSA:3.40.1350.10tRNA_endonuc-like_dom_sfGENE3D
PTHR21227TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN2tRNA_splicPANTHER
PIRSF011789tRNA_endo_SEN2tRNA_splic_SEN2PIRSF

Orthologs

References / Literature

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:30228203 - From powerhouse to processing plant: conserved roles of mitochondrial outer membrane proteins in tRNA splicing.
Wan Y et al. Genes Dev 2018 Oct 01;32(19-20):1309-1314
PMID:33109728 - High-Throughput Identification of Nuclear Envelope Protein Interactions in Schizosaccharomyces pombe Using an Arrayed Membrane Yeast-Two Hybrid Library.
Varberg JM et al. G3 (Bethesda) 2020 Dec 03;10(12):4649-4663
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623