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protein coding gene - ost3 (SPAPB17E12.11) - oligosaccharyltransferase complex gamma subunit, Ost3

Gene summary

Standard name
ost3
Systematic ID
SPAPB17E12.11
Product
oligosaccharyltransferase complex gamma subunit, Ost3
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q8TFH3
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome I: 1283107..1284482 forward strand

Annotation

Disease association

MONDO:0015286 - congenital disorder of glycosylation

References:

MONDO:0026729 - congenital disorder of glycosylation, type ICC

References:

MONDO:0012615 - intellectual disability, autosomal recessive 7

References:

MONDO:0005066 - metabolic disease

References:

MONDO:0010455 - X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia

References:

GO biological process

GO:0006487 - protein N-linked glycosylation

References:

GO cellular component

GO:0005783 - endoplasmic reticulum

References:

GO:0008250 - oligosaccharyltransferase complex

References:

GO molecular function

GO:0004579 - dolichyl-diphosphooligosaccharide-protein glycotransferase activity

References:

Modification

MOD:00689 - disulfide crosslinked residues

References:

MOD:01148 - ubiquitinylated lysine

References:

Protein features

PBO:0111760 - thioredoxin family

Protein sequence feature

SO:0000418 - signal_peptide

References:

SO:0001812 - transmembrane_helix

References:

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0002420 - inviable after spore germination, single cell division, abnormal cell shape

References:

Genotypes:

FYPO:0002151 - inviable spore

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF04756OST3_OST6MAGT1/OST3/OST6Pfam
cd02947TRX_familyCDD
G3DSA:3.40.30.10Thioredoxin-like_sfCATH-Gene3D
SSF52833Thioredoxin-like_sfSUPERFAMILY
PTHR12692PANTHER
Transmembrane alpha helixDeepTMHMM
Signal PeptideSignal-Peptide-DeepTMHMM

Orthologs

References / Literature

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.
Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:24713849 - Post-transcriptional regulation of meiotic genes by a nuclear RNA silencing complex.
Egan ED et al. RNA 2014 Jun;20(6):867-81
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PB_REF:0000003 - Disease Association Curation
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531