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protein coding gene - cwp1 (SPAPB1A10.04c) - geranylgeranyltransferase I and farnesyltransferase alpha subunit Cwp1

Gene summary

Standard name
cwp1
Systematic ID
SPAPB1A10.04c
Product
geranylgeranyltransferase I and farnesyltransferase alpha subunit Cwp1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O60052
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 1864551..1865771 reverse strand

Annotation

GO biological process

GO:0007323 - peptide pheromone maturation

References:

GO:0072659 - protein localization to plasma membrane

References:

GO cellular component

GO:0005953 - CAAX-protein geranylgeranyltransferase complex

References:

GO:0005634 - nucleus

References:

GO:0005965 - protein farnesyltransferase complex

References:

GO molecular function

GO:0004662 - CAAX-protein geranylgeranyltransferase activity

References:

GO:0005515 - protein binding

References:

GO:0004660 - protein farnesyltransferase activity

References:

GO:0004661 - protein geranylgeranyltransferase activity

References:

GO:0004663 - Rab geranylgeranyltransferase activity

References:

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0002148 - inviable after spore germination, multiple cell divisions, abnormal morphology

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF01239PPTAPrenyl_trans_aPfam
PS51147PFTAPrenyl_trans_aPROSITE profiles
G3DSA:1.25.40.120:FF:000026CATH-FunFam
G3DSA:1.25.40.120CATH-Gene3D
SSF48439SUPERFAMILY
PTHR11129PANTHER

Orthologs

References / Literature

PMID:20118936 - Schizosaccharomyces pombe genome-wide nucleosome mapping reveals positioning mechanisms distinct from those of Saccharomyces cerevisiae.
Lantermann AB et al. Nat Struct Mol Biol 2010 Feb;17(2):251-7
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:10617635 - Protein farnesylation is critical for maintaining normal cell morphology and canavanine resistance in Schizosaccharomyces pombe.
Yang W et al. J Biol Chem 2000 Jan 07;275(1):429-38
PMID:16624901 - A defect in protein farnesylation suppresses a loss of Schizosaccharomyces pombe tsc2+, a homolog of the human gene predisposing to tuberous sclerosis complex.
Nakase Y et al. Genetics 2006 Jun;173(2):569-78
PMID:9781874 - Characterization of the geranylgeranyl transferase type I from Schizosaccharomyces pombe.
Arellano M et al. Mol Microbiol 1998 Sep;29(6):1357-67
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:8665904 - Enzymic characterization of fission yeast farnesyl transferase: recognition of the -CAAL motif at the C-terminus.
Danjoh I et al. Eur J Biochem 1996 Mar 15;236(3):847-51
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323