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protein coding gene - ase1 (SPAPB1A10.09) - antiparallel microtubule cross-linking factor Ase1

Gene summary

Standard name
ase1
Systematic ID
SPAPB1A10.09
Product
antiparallel microtubule cross-linking factor Ase1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q9HDY1
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 1878189..1880726 forward strand

Annotation

GO biological process

GO:0030989 - dynein-driven meiotic oscillatory nuclear movement

References:

GO:0032118 - horsetail-astral microtubule organization

References:

GO:0051232 - meiotic spindle elongation

References:

GO:0140642 - meiotic spindle formation (spindle phase two)

References:

GO:0001578 - microtubule bundle formation

References:

GO:0044878 - mitotic cytokinesis checkpoint signaling

References:

GO:0140515 - mitotic nuclear bridge organization

References:

GO:0000022 - mitotic spindle elongation

References:

GO:0061804 - mitotic spindle formation (spindle phase one)

References:

GO:0140641 - mitotic spindle formation (spindle phase two)

References:

GO:0051256 - mitotic spindle midzone assembly

References:

GO:0062168 - negative regulation of plus-end directed microtubule sliding

References:

GO:0098863 - nuclear migration by microtubule mediated pushing forces

References:

GO cellular component

GO:0055028 - cortical microtubule

References:

GO:0005881 - cytoplasmic microtubule

References:

GO:0000923 - equatorial microtubule organizing center

References:

GO:1990385 - meiotic spindle midzone

References:

GO:0015630 - microtubule cytoskeleton

References:

GO:1990498 - mitotic spindle microtubule

References:

GO:1990023 - mitotic spindle midzone

References:

GO:0005634 - nucleus

References:

GO:0005827 - polar microtubule

References:

GO:1905759 - post-anaphase array microtubule

References:

GO:1990295 - post-anaphase microtubule array

References:

GO:0099070 - static microtubule bundle

References:

GO molecular function

GO:0008017 - microtubule binding

References:

GO:0099609 - microtubule lateral binding

References:

GO:0005515 - protein binding

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:00047 - O-phospho-L-threonine

References:

MOD:00048 - O4'-phospho-L-tyrosine

References:

MOD:00696 - phosphorylated residue

References:

Multi-locus phenotype

FYPO:0007756 - abnormal homologous chromosome segregation with collapsed spindle

References:

Genotypes:

FYPO:0000131 - abnormal mitotic spindle elongation

References:

Genotypes:

FYPO:0003350 - abolished protein localization to mitotic spindle midzone during anaphase B

References:

Genotypes:

FYPO:0000705 - abolished protein-protein interaction

References:

Genotypes:

FYPO:0003165 - cut with abnormal chromosome segregation

References:

Genotypes:

FYPO:0001053 - cut, normal size cell

References:

Genotypes:

FYPO:0007150 - decreased microtubule bundle formation

References:

Genotypes:

FYPO:0005343 - decreased rate of mitotic spindle elongation during anaphase B

References:

Genotypes:

FYPO:0001355 - decreased vegetative cell population growth

References:

Genotypes:

FYPO:0000316 - inviable after spore germination

References:

Genotypes:

FYPO:0000049 - inviable cell

References:

Genotypes:

FYPO:0002059 - inviable cell population

References:

Genotypes:

FYPO:0002303 - inviable mononucleate monoseptate vegetative cell with anucleate compartment

References:

Genotypes:

FYPO:0002150 - inviable spore population

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0004101 - lagging mitotic chromosomes, with complete sister chromatid separation

References:

Genotypes:

FYPO:0002401 - microtubule bundles present in increased numbers

References:

Genotypes:

FYPO:0000324 - mitotic metaphase/anaphase transition delay

References:

Genotypes:

FYPO:0008007 - mitotic spindle collapse during anaphase B elongation with progressive spindle pole congression

References:

Genotypes:

FYPO:0000276 - monopolar mitotic spindle

References:

Genotypes:

FYPO:0006259 - normal mitotic spindle length during metaphase

References:

Genotypes:

FYPO:0007106 - normal mitotic spindle morphology

References:

Genotypes:

FYPO:0006917 - normal onset of mitotic metaphase/anaphase transition

References:

Genotypes:

FYPO:0003250 - premature septum assembly

References:

Genotypes:

FYPO:0003559 - sensitive to doxorubicin

References:

Genotypes:

FYPO:0004395 - short bipolar mitotic spindle during metaphase

References:

Genotypes:

FYPO:0007846 - short meiotic spindle during anaphase I

References:

Genotypes:

FYPO:0007755 - short meiotic spindle during metaphase I

References:

Genotypes:

FYPO:0007103 - spindle collapse during meiosis I

References:

Genotypes:

FYPO:0007744 - spindle collapse during meiotic prophase I

References:

Genotypes:

FYPO:0007849 - spindle self-assembly during meiosis I

References:

Genotypes:

FYPO:0007961 - transient abrupt spindle length decrease at anaphase onset

References:

Genotypes:

FYPO:0000678 - unequal homologous chromosome segregation

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0001778 - abnormal centromere localization

References:

Genotypes:

FYPO:0007975 - abnormal distribution of interpolar microtubule rescue during anaphase B

References:

Genotypes:

FYPO:0007756 - abnormal homologous chromosome segregation with collapsed spindle

References:

Genotypes:

FYPO:0000197 - abnormal horsetail movement

References:

Genotypes:

FYPO:0007981 - abnormal interpolar microtubule length distribution during anaphase B

References:

Genotypes:

FYPO:0005558 - abnormal microtubule bundle

References:

Genotypes:

FYPO:0007126 - abnormal microtubule bundle formation during mitotic spindle assembly

References:

Genotypes:

FYPO:0007548 - abnormal mitotic nuclear bridge midzone membrane domain organization

References:

Genotypes:

FYPO:0000141 - abnormal mitotic sister chromatid segregation

References:

Genotypes:

FYPO:0007547 - abnormal nuclear pore localization to mitotic nuclear bridge midzone membrane

References:

Genotypes:

FYPO:0004316 - abnormal post-anaphase array

References:

Genotypes:

FYPO:0003484 - abolished protein localization to mitotic spindle midzone

References:

Genotypes:

FYPO:0004412 - abolished protein localization to mitotic spindle midzone during anaphase

References:

Genotypes:

FYPO:0003350 - abolished protein localization to mitotic spindle midzone during anaphase B

References:

Genotypes:

FYPO:0000705 - abolished protein-protein interaction

References:

Genotypes:

FYPO:0004700 - bent vegetative cell

References:

Genotypes:

FYPO:0000229 - cut

References:

Genotypes:

FYPO:0003165 - cut with abnormal chromosome segregation

References:

Genotypes:

FYPO:0003743 - decreased cell population growth during glucose starvation

References:

Genotypes:

FYPO:0000684 - decreased cell population growth on glycerol carbon source

References:

Genotypes:

FYPO:0002924 - decreased cell population growth on maltose carbon source

References:

Genotypes:

FYPO:0007150 - decreased microtubule bundle formation

References:

Genotypes:

FYPO:0003841 - decreased protein localization to mitotic spindle midzone

References:

Genotypes:

FYPO:0002679 - decreased protein phosphorylation

References:

Genotypes:

FYPO:0005343 - decreased rate of mitotic spindle elongation during anaphase B

References:

Genotypes:

FYPO:0007960 - decreased rate of mitotic spindle elongation during prophase

References:

Genotypes:

FYPO:0000584 - decreased sporulation frequency

References:

Genotypes:

FYPO:0003938 - increased cell population growth during glucose starvation

References:

Genotypes:

FYPO:0009072 - increased cell population growth on lysine nitrogen source

References:

Genotypes:

FYPO:0001840 - increased minichromosome loss during vegetative growth

References:

Genotypes:

FYPO:0007971 - increased rate of interpolar microtubule polymerization during mitotic anaphase B

References:

Genotypes:

FYPO:0007974 - increased rate of interpolar microtubule polymerization inside the mitotic nuclear membrane bridge

References:

Genotypes:

FYPO:0000252 - increased spontaneous diploidization

References:

Genotypes:

FYPO:0004557 - increased vegetative cell population growth

References:

Genotypes:

FYPO:0002303 - inviable mononucleate monoseptate vegetative cell with anucleate compartment

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0006716 - large and small daughter nuclei, with unequal nuclear envelope distribution

References:

Genotypes:

FYPO:0006518 - loss of viability in G0

References:

Genotypes:

FYPO:0002818 - microtubule bundles present in decreased numbers

References:

Genotypes:

FYPO:0002401 - microtubule bundles present in increased numbers

References:

Genotypes:

FYPO:0000339 - mislocalized septum during vegetative growth

References:

Genotypes:

FYPO:0000324 - mitotic metaphase/anaphase transition delay

References:

Genotypes:

FYPO:0006475 - mitotic spindle collapse

References:

Genotypes:

FYPO:0005722 - mitotic spindle collapse during anaphase B elongation

References:

Genotypes:

FYPO:0006643 - mitotic spindle collapse without elongation during metaphase

References:

Genotypes:

FYPO:0002688 - mitotic spindle collapse without elongation during prophase

References:

Genotypes:

FYPO:0007753 - multiple spindles during meiosis I

References:

Genotypes:

FYPO:0007553 - normal G1 to G0 transition

References:

Genotypes:

FYPO:0003326 - normal interphase microtubule nucleation

References:

Genotypes:

FYPO:0002966 - normal protein localization to mitotic spindle

References:

Genotypes:

FYPO:0003349 - normal protein localization to mitotic spindle midzone during anaphase B

References:

Genotypes:

FYPO:0007124 - normal protein localization to mitotic spindle midzone during prophase

References:

Genotypes:

FYPO:0000703 - normal protein-protein interaction

References:

Genotypes:

FYPO:0005342 - normal rate of mitotic spindle elongation during anaphase B

References:

Genotypes:

FYPO:0003302 - nucleus mislocalized towards cell tip during mitotic interphase

References:

Genotypes:

FYPO:0000763 - resistance to cadmium

References:

Genotypes:

FYPO:0000764 - resistance to cycloheximide

References:

Genotypes:

FYPO:0001103 - resistance to hydrogen peroxide

References:

Genotypes:

FYPO:0009085 - resistance to lithium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0003383 - resistance to tert-butyl hydroperoxide

References:

Genotypes:

FYPO:0001098 - sensitive to 4-nitroquinoline N-oxide

References:

Genotypes:

FYPO:0004325 - sensitive to 5-fluorouracil

References:

Genotypes:

FYPO:0000085 - sensitive to camptothecin

References:

Genotypes:

FYPO:0003840 - sensitive to carbendazim

References:

Genotypes:

FYPO:0000102 - sensitive to cisplatin

References:

Genotypes:

FYPO:0003559 - sensitive to doxorubicin

References:

Genotypes:

FYPO:0007931 - sensitive to egtazic acid

References:

Genotypes:

FYPO:0000785 - sensitive to formamide

References:

Genotypes:

FYPO:0000088 - sensitive to hydroxyurea

References:

Genotypes:

FYPO:0009071 - sensitive to itraconazole

References:

Genotypes:

FYPO:0009088 - sensitive to magnesium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0000089 - sensitive to methyl methanesulfonate

References:

Genotypes:

FYPO:0001214 - sensitive to potassium chloride

References:

Genotypes:

FYPO:0007938 - sensitive to tea tree oil

References:

Genotypes:

FYPO:0000091 - sensitive to thiabendazole

References:

Genotypes:

FYPO:0002546 - sensitive to trichostatin A

References:

Genotypes:

FYPO:0003656 - sensitive to vanadate

References:

Genotypes:

FYPO:0007304 - short bipolar mitotic spindle during anaphase

References:

Genotypes:

FYPO:0004395 - short bipolar mitotic spindle during metaphase

References:

Genotypes:

FYPO:0007755 - short meiotic spindle during metaphase I

References:

Genotypes:

FYPO:0007103 - spindle collapse during meiosis I

References:

Genotypes:

FYPO:0007752 - spindle regression during meiosis I

References:

Genotypes:

FYPO:0000013 - T-shaped vegetative cell with normal cell length

References:

Genotypes:

FYPO:0003500 - viable branched, elongated, multiseptate vegetative cell

References:

Genotypes:

FYPO:0001496 - viable elongated multiseptate vegetative cell

References:

Genotypes:

FYPO:0003481 - viable elongated vegetative cell, elongated upon mitotic entry

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF03999MAP65_ASE1Pfam
G3DSA:1.20.58.1520CATH-Gene3D
SSF46966SUPERFAMILY
PTHR19321MAP65_Ase1_PRC1PANTHER
CoilCOILS
mobidb-lite-Disorderdisorder_predictionMobiDB-Disorder
mobidb-lite-Low-complexitydisorder_predictionMobiDB-Low-complexity
mobidb-lite-Polardisorder_predictionMobiDB-Polar

Orthologs

References / Literature

PMID:36108046 - Recovery from spindle checkpoint-mediated arrest requires a novel Dnt1-dependent APC/C activation mechanism.
Bai S et al. PLoS Genet 2022 Sep;18(9):e1010397
PMID:19948483 - Ase1/Prc1-dependent spindle elongation corrects merotely during anaphase in fission yeast.
Courtheoux T et al. J Cell Biol 2009 Nov 02;187(3):399-412
PMID:25963819 - Nucleocytoplasmic transport in the midzone membrane domain controls yeast mitotic spindle disassembly.
Lucena R et al. J Cell Biol 2015 May 11;209(3):387-402
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:19547744 - Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.
Beltrao P et al. PLoS Biol 2009 Jun 16;7(6):e1000134
PMID:36980258 - Actin-Microtubule Crosstalk Imparts Stiffness to the Contractile Ring in Fission Yeast.
Bellingham-Johnstun K et al. Cells 2023 Mar 16;12(6)
PMID:21340088 - Microarray-based target identification using drug hypersensitive fission yeast expressing ORFeome.
Arita Y et al. Mol Biosyst 2011 May;7(5):1463-72
PMID:27984725 - CDK Substrate Phosphorylation and Ordering the Cell Cycle.
Swaffer MP et al. Cell 2016 Dec 15;167(7):1750-1761.e16
PMID:30427751 - The J-domain cochaperone Rsp1 interacts with Mto1 to organize noncentrosomal microtubule assembly.
Shen J et al. Mol Biol Cell 2019 Jan 15;30(2):256-267
PMID:19029336 - Schizosaccharomyces pombe Pak-related protein, Pak1p/Orb2p, phosphorylates myosin regulatory light chain to inhibit cytokinesis.
Loo TH et al. J Cell Biol 2008 Dec 01;183(5):785-93
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:24806815 - Mdb1, a fission yeast homolog of human MDC1, modulates DNA damage response and mitotic spindle function.
Wei Y et al. PLoS One 2014;9(5):e97028
PMID:24239120 - Antagonistic spindle motors and MAPs regulate metaphase spindle length and chromosome segregation.
Syrovatkina V et al. Curr Biol 2013 Dec 02;23(23):2423-9
PMID:23365689 - Cellular robustness conferred by genetic crosstalk underlies resistance against chemotherapeutic drug doxorubicin in fission yeast.
Tay Z et al. PLoS One 2013;8(1):e55041
PMID:31615768 - CLASP promotes microtubule bundling in metaphase spindle independently of Ase1/PRC1 in fission yeast.
Ebina H et al. Biol Open 2019 Oct 24;8(10)
PMID:18562692 - Latrunculin A delays anaphase onset in fission yeast by disrupting an Ase1-independent pathway controlling mitotic spindle stability.
Meadows JC et al. Mol Biol Cell 2008 Sep;19(9):3713-23
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:21151990 - The fission yeast XMAP215 homolog Dis1p is involved in microtubule bundle organization.
Roque H et al. PLoS One 2010 Dec 02;5(12):e14201
PMID:28513584 - Kinesin-5-independent mitotic spindle assembly requires the antiparallel microtubule crosslinker Ase1 in fission yeast.
Rincon SA et al. Nat Commun 2017 May 17;8:15286
PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.
Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514
PMID:30806623 - Kinesin-6 regulates cell-size-dependent spindle elongation velocity to keep mitosis duration constant in fission yeast.
Krüger LK et al. Elife 2019 Feb 26;8
PMID:32723864 - Klp2 and Ase1 synergize to maintain meiotic spindle stability during metaphase I.
Zheng F et al. J Biol Chem 2020 Sep 18;295(38):13287-13298
PMID:33260998 - High-Throughput Flow Cytometry Combined with Genetic Analysis Brings New Insights into the Understanding of Chromatin Regulation of Cellular Quiescence.
Zahedi Y et al. Int J Mol Sci 2020 Nov 27;21(23)
PMID:25669599 - Fitness profiling links topoisomerase II regulation of centromeric integrity to doxorubicin resistance in fission yeast.
Nguyen TT et al. Sci Rep 2015 Feb 11;5:8400
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:19264558 - Screening a genome-wide S. pombe deletion library identifies novel genes and pathways involved in genome stability maintenance.
Deshpande GP et al. DNA Repair (Amst) 2009 May 01;8(5):672-9
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:37445861 - Resistance to Chemotherapeutic 5-Fluorouracil Conferred by Modulation of Heterochromatic Integrity through Ino80 Function in Fission Yeast.
Lim KK et al. Int J Mol Sci 2023 Jun 26;24(13)
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:26791325 - Predicting chemotherapeutic drug combinations through gene network profiling.
Nguyen TT et al. Sci Rep 2016 Jan 21;6:18658
PMID:34080538 - Kinesin-6 Klp9 orchestrates spindle elongation by regulating microtubule sliding and growth.
Krüger LK et al. Elife 2021 Jun 03;10
PMID:17254972 - Crosslinkers and motors organize dynamic microtubules to form stable bipolar arrays in fission yeast.
Janson ME et al. Cell 2007 Jan 26;128(2):357-68
PMID:35293864 - Microtubule rescue at midzone edges promotes overlap stability and prevents spindle collapse during anaphase B.
Lera-Ramirez M et al. Elife 2022 Mar 16;11
PMID:24713849 - Post-transcriptional regulation of meiotic genes by a nuclear RNA silencing complex.
Egan ED et al. RNA 2014 Jun;20(6):867-81
PMID:18931302 - Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes.
Dixon SJ et al. Proc Natl Acad Sci U S A 2008 Oct 28;105(43):16653-8
PMID:23297348 - Comprehensive proteomics analysis reveals new substrates and regulators of the fission yeast clp1/cdc14 phosphatase.
Chen JS et al. Mol Cell Proteomics 2013 May;12(5):1074-86
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:15689489 - Ase1p organizes antiparallel microtubule arrays during interphase and mitosis in fission yeast.
Loïodice I et al. Mol Biol Cell 2005 Apr;16(4):1756-68
PMID:36793083 - The SAGA histone acetyltransferase module targets SMC5/6 to specific genes.
Mahrik L et al. Epigenetics Chromatin 2023 Feb 16;16(1):6
PMID:15837798 - Efficient formation of bipolar microtubule bundles requires microtubule-bound gamma-tubulin complexes.
Janson ME et al. J Cell Biol 2005 Apr 25;169(2):297-308
PMID:31089172 - Kinesin-6 Klp9 plays motor-dependent and -independent roles in collaboration with Kinesin-5 Cut7 and the microtubule crosslinker Ase1 in fission yeast.
Yukawa M et al. Sci Rep 2019 May 14;9(1):7336
PMID:26124291 - A stable microtubule array drives fission yeast polarity reestablishment upon quiescence exit.
Laporte D et al. J Cell Biol 2015 Jul 06;210(1):99-113
PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.
Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684
PMID:18818364 - Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast.
Roguev A et al. Science 2008 Oct 17;322(5900):405-10
PMID:19879140 - The fission yeast TACC protein Mia1p stabilizes microtubule arrays by length-independent crosslinking.
Thadani R et al. Curr Biol 2009 Nov 17;19(21):1861-8
PMID:29021344 - A microtubule polymerase cooperates with the kinesin-6 motor and a microtubule cross-linker to promote bipolar spindle assembly in the absence of kinesin-5 and kinesin-14 in fission yeast.
Yukawa M et al. Mol Biol Cell 2017 Dec 01;28(25):3647-3659
PMID:26167880 - SR protein kinases promote splicing of nonconsensus introns.
Lipp JJ et al. Nat Struct Mol Biol 2015 Aug;22(8):611-7
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:32502403 - Selective Nuclear Pore Complex Removal Drives Nuclear Envelope Division in Fission Yeast.
Expósito-Serrano M et al. Curr Biol 2020 Aug 17;30(16):3212-3222.e2
PMID:19686686 - Phospho-regulated interaction between kinesin-6 Klp9p and microtubule bundler Ase1p promotes spindle elongation.
Fu C et al. Dev Cell 2009 Aug;17(2):257-67
PMID:24963130 - The KASH protein Kms2 coordinates mitotic remodeling of the spindle pole body.
Wälde S et al. J Cell Sci 2014 Aug 15;127(Pt 16):3625-40
PMID:21892183 - Adaptive braking by Ase1 prevents overlapping microtubules from sliding completely apart.
Braun M et al. Nat Cell Biol 2011 Sep 04;13(10):1259-64
PMID:28178520 - Identification of a Sgo2-Dependent but Mad2-Independent Pathway Controlling Anaphase Onset in Fission Yeast.
Meadows JC et al. Cell Rep 2017 Feb 07;18(6):1422-1433
PMID:15647375 - The roles of fission yeast ase1 in mitotic cell division, meiotic nuclear oscillation, and cytokinesis checkpoint signaling.
Yamashita A et al. Mol Biol Cell 2005 Mar;16(3):1378-95
PMID:17579515 - The spindle pole bodies facilitate nuclear envelope division during closed mitosis in fission yeast.
Zheng L et al. PLoS Biol 2007 Jul;5(7):e170
PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.
Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895
PMID:34346498 - Loss of kinesin-8 improves the robustness of the self-assembled spindle in Schizosaccharomyces pombe.
Pineda-Santaella A et al. J Cell Sci 2021 Aug 15;134(16)
PMID:38442865 - The fission yeast NDR kinase Orb6 and its signalling pathway MOR regulate cytoplasmic microtubule organization during the cell cycle.
Kume K et al. Open Biol 2024 Mar;14(3):230440
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.
Halova L et al. Open Biol 2021 Apr;11(4):200405
PMID:20537132 - Global fitness profiling of fission yeast deletion strains by barcode sequencing.
Han TX et al. Genome Biol 2010;11(6):R60
PMID:18061564 - Stabilization of overlapping microtubules by fission yeast CLASP.
Bratman SV et al. Dev Cell 2007 Dec;13(6):812-27
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.
Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.
Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6
PMID:15857958 - Roles of Pdk1p, a fission yeast protein related to phosphoinositide-dependent protein kinase, in the regulation of mitosis and cytokinesis.
Bimbó A et al. Mol Biol Cell 2005 Jul;16(7):3162-75
PMID:23394829 - Identification of SIN pathway targets reveals mechanisms of crosstalk between NDR kinase pathways.
Gupta S et al. Curr Biol 2013 Feb 18;23(4):333-8
PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.
Lee J et al. Nat Commun 2017 Feb 20;8:14527
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053