protein coding gene - mse1 (SPAPB1A10.11c) - mitochondrial glutamyl-tRNA ligase Mse1

Gene summary

Standard name: mse1
Systematic ID: SPAPB1A10.11c
Product: mitochondrial glutamyl-tRNA ligase Mse1
Organism: Schizosaccharomyces pombe (fission yeast)
Synonyms: ers2
UniProt ID: Q9HDX9
Characterisation status: biological role published
Feature type: mRNA gene
Genomic location: chromosome I: 1882300..1884148 reverse strand

Annotation

Disease association

MONDO:0000732 - combined oxidative phosphorylation deficiency

References:

PB_REF:0000003

MONDO:0013971 - leukoencephalopathy-thalamus and brainstem anomalies-high lactate syndrome

References:

PB_REF:0000006

GO biological process

GO:0006424 - glutamyl-tRNA aminoacylation

References:

GO_REF:0000033

GO:0032543 - mitochondrial translation

References:

GO_REF:0000024

GO cellular component

GO:0005759 - mitochondrial matrix

References:

GO_REF:0000111

GO:0005739 - mitochondrion

References:

PMID:16823372

GO molecular function

GO:0005524 - ATP binding

References:

GO_REF:0000002

GO:0004818 - glutamate-tRNA ligase activity

References:

GO_REF:0000033

GO:0005515 - protein binding

References:

PMID:19502729

GO:0000049 - tRNA binding

References:

GO_REF:0000002

GO:0008270 - zinc ion binding

References:

GO_REF:0000002

Protein sequence feature

SO:0001808 - mitochondrial_targeting_signal

References:

PMID:36408920

Qualitative gene expression

PomGeneEx:0000012 - RNA level decreased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

PMID:23101633

Single locus phenotype

FYPO:0000278 - decreased cell population growth following spore germination

References:

PMID:19502729

Genotypes:

mse1+(wild type)[Overexpression]

FYPO:0001407 - decreased cell population growth on glucose carbon source

References:

PMID:19502729

Genotypes:

mse1+(wild type)[Overexpression]

FYPO:0001043 - increased mating efficiency

References:

PMID:19502729

Genotypes:

mse1+(wild type)[Overexpression]

FYPO:0002733 - inviable after spore germination, multiple cell divisions, elongated tapered cell

References:

PMID:19502729

Genotypes:

mse1delta

FYPO:0002111 - inviable tapered vegetative cell

References:

PMID:23697806

Genotypes:

mse1delta

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

mse1delta

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

ID	Name	InterPro name	DB name
PF00749	tRNA-synt_1c	Glu/Gln-tRNA-synth_Ib_cat-dom	PFAM
PF19269	Anticodon_2	aa-tRNA-synth_I_cd-bd	PFAM
cd00808	GluRS_core	GluRS_core	CDD
PR00987	TRNASYNTHGLU	Glu/Gln-tRNA-synth	PRINTS
G3DSA:3.40.50.620:FF:000045			FUNFAM
SSF48163	An anticodon-binding domain of class I aminoacyl-tRNA synthetases	aa_tRNA-synth_I_cd-bd_sf	SUPERFAMILY
SSF52374	Nucleotidylyl transferase		SUPERFAMILY
G3DSA:3.40.50.620	HUPs	Rossmann-like_a/b/a_fold	GENE3D
G3DSA:1.10.10.350		aa-tRNA-synth_I_codon-bd_sub2	GENE3D
PTHR43311	GLUTAMATE--TRNA LIGASE	GluQ/Sye	PANTHER
MF_00022	Glu_tRNA_synth_type1	Glu-tRNA-ligase_bac/mito	HAMAP
TIGR00464	gltX_bact	Glu-tRNA-ligase_bac/mito	NCBIFAM

Orthologs

EARS2 (HGNC:29419) Homo sapiens
mse1 (SJAG_03071) Schizosaccharomyces japonicus
MSE1 (YOL033W) Saccharomyces cerevisiae

References / Literature

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.: Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:19502729 - Glutamyl tRNA synthetases and glutamic acid induce sexual differentiation of Schizosaccharomyces pombe.: Paul SK et al. Biosci Biotechnol Biochem 2009 Jun;73(6):1339-47
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.: Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.: Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.: UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:19682301 - A large complex mediated by Moc1, Moc2 and Cpc2 regulates sexual differentiation in fission yeast.: Paul SK et al. FEBS J 2009 Sep;276(18):5076-93
GO_REF:0000002 - Comments
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).: Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.: Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.: Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
GO_REF:0000033 - Annotation inferences using phylogenetic trees
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:21511999 - Comparative functional genomics of the fission yeasts.: Rhind N et al. Science 2011 May 20;332(6032):930-6
PB_REF:0000003 - Disease Association Curation