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protein coding gene - rpc17 (SPAPB1E7.10) - DNA-directed RNA polymerase III complex subunit Rpc17

Gene summary

Standard name
rpc17
Systematic ID
SPAPB1E7.10
Product
DNA-directed RNA polymerase III complex subunit Rpc17
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q9C0Z9
ORFeome ID
41/B05
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 3316846..3317528 forward strand

Annotation

GO biological process

GO:0006384 - transcription initiation at RNA polymerase III promoter

References:

GO cellular component

GO:0005829 - cytosol

References:

GO:0005634 - nucleus

References:

GO:0005666 - RNA polymerase III complex

References:

GO molecular function

GO:0003899 - DNA-directed RNA polymerase activity

References:

GO:0005515 - protein binding

References:

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

References:

PomGeneEx:0000027 - ribosomal density decreased

References:

PomGeneEx:0000012 - RNA level decreased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0001511 - inviable vegetative cell, abnormal cell shape, normal cell size

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF03874RNA_pol_Rpb4Rpb4/RPC9Pfam
SM00657RPOL4cRNA_pol_Rpb4/RPC9_coreSMART
G3DSA:1.20.1250.40:FF:000020CATH-FunFam
G3DSA:1.20.1250.40Rpb4/RPC9_sfCATH-Gene3D
SSF47819HRDC-like_sfSUPERFAMILY
PTHR15561RPC9PANTHER

Orthologs

References / Literature

PMID:25392932 - RNA processing factors Swd2.2 and Sen1 antagonize RNA Pol III-dependent transcription and the localization of condensin at Pol III genes.
Legros P et al. PLoS Genet 2014 Nov;10(11):e1004794
PMID:21714024 - Crystal structure of the C17/25 subcomplex from Schizosaccharomyces pombe RNA polymerase III.
Ehara H et al. Protein Sci 2011 Sep;20(9):1558-65
PMID:22540037 - Predicting the fission yeast protein interaction network.
Pancaldi V et al. G3 (Bethesda) 2012 Apr;2(4):453-67
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.
Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:31626996 - Multiplexed proteome profiling of carbon source perturbations in two yeast species with SL-SP3-TMT.
Paulo JA et al. J Proteomics 2020 Jan 06;210:103531
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:15612920 - Rpc25, a conserved RNA polymerase III subunit, is critical for transcription initiation.
Zaros C et al. Mol Microbiol 2005 Jan;55(1):104-14
PMID:16877568 - Ancient origin, functional conservation and fast evolution of DNA-dependent RNA polymerase III.
Proshkina GM et al. Nucleic Acids Res 2006;34(13):3615-24
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623