protein coding gene - cig2 (SPAPB2B4.03) - G1/S-specific B-type cyclin Cig2

Gene summary

Standard name

cig2

Systematic ID

SPAPB2B4.03

Product

G1/S-specific B-type cyclin Cig2

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

cyc17

UniProt ID

P36630

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 2709782..2714162 forward strand

Annotation

Protein features

Orthologs

• CCNB1 (HGNC:1579) Homo sapiens
• CCNB2 (HGNC:1580) Homo sapiens
• CCNB3 (HGNC:18709) Homo sapiens
• cig2 (SJAG_01401) Schizosaccharomyces japonicus
• CLB1 (YGR108W) Saccharomyces cerevisiae
• CLB2 (YPR119W) Saccharomyces cerevisiae

References / Literature

PMID:15173168 - Cds1 phosphorylation by Rad3-Rad26 kinase is mediated by forkhead-associated domain interaction with Mrc1.

Tanaka K et al. J Biol Chem 2004 Jul 30;279(31):32079-86

PMID:12419251 - Stable association of mitotic cyclin B/Cdc2 to replication origins prevents endoreduplication.

Wuarin J et al. Cell 2002 Nov 01;111(3):419-31

PMID:7909513 - A B-type cyclin negatively regulates conjugation via interacting with cell cycle 'start' genes in fission yeast.

Obara-Ishihara T et al. EMBO J 1994 Apr 15;13(8):1863-72

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:26912660 - Gad8 Protein Is Found in the Nucleus Where It Interacts with the MluI Cell Cycle Box-binding Factor (MBF) Transcriptional Complex to Regulate the Response to DNA Replication Stress.

Cohen A et al. J Biol Chem 2016 Apr 22;291(17):9371-81

PMID:8264644 - Interaction between the Cig1 and Cig2 B-type cyclins in the fission yeast cell cycle.

Connolly T et al. Mol Cell Biol 1994 Jan;14(1):768-76

PMID:8521500 - p25rum1 orders S phase and mitosis by acting as an inhibitor of the p34cdc2 mitotic kinase.

Correa-Bordes J et al. Cell 1995 Dec 15;83(6):1001-9

PMID:22907753 - Posttranscriptional regulation of cell-cell interaction protein-encoding transcripts by Zfs1p in Schizosaccharomyces pombe.

Wells ML et al. Mol Cell Biol 2012 Oct;32(20):4206-14

PMID:10725227 - A fission yeast general translation factor reveals links between protein synthesis and cell cycle controls.

Grallert B et al. J Cell Sci 2000 Apr;113 ( Pt 8):1447-58

PMID:8887552 - A novel S phase inhibitor in fission yeast.

Woollard A et al. EMBO J 1996 Sep 02;15(17):4603-12

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:9436991 - Negative regulation of Cdc18 DNA replication protein by Cdc2.

Lopez-Girona A et al. Mol Biol Cell 1998 Jan;9(1):63-73

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:1829983 - A fission yeast B-type cyclin functioning early in the cell cycle.

Bueno A et al. Cell 1991 Jul 12;66(1):149-59

PMID:9201720 - Ran1 functions to control the Cdc10/Sct1 complex through Puc1.

Caligiuri M et al. Mol Biol Cell 1997 Jun;8(6):1117-28

PMID:21971174 - Abundance of prereplicative complexes (Pre-RCs) facilitates recombinational repair under replication stress in fission yeast.

Maki K et al. J Biol Chem 2011 Dec 02;286(48):41701-41710

PMID:14648198 - DSC1-MCB regulation of meiotic transcription in Schizosaccharomyces pombe.

Cunliffe L et al. Mol Genet Genomics 2004 Feb;271(1):60-71

PMID:23950735 - Global analysis of fission yeast mating genes reveals new autophagy factors.

Sun LL et al. PLoS Genet 2013;9(8):e1003715

PMID:9303310 - p25rum1 promotes proteolysis of the mitotic B-cyclin p56cdc13 during G1 of the fission yeast cell cycle.

Correa-Bordes J et al. EMBO J 1997 Aug 01;16(15):4657-64

PMID:32084401 - The Hydrophobic Patch Directs Cyclin B to Centrosomes to Promote Global CDK Phosphorylation at Mitosis.

Basu S et al. Curr Biol 2020 Mar 09;30(5):883-892.e4

PMID:19366728 - Genetic control of cellular quiescence in S. pombe.

Sajiki K et al. J Cell Sci 2009 May 01;122(Pt 9):1418-29

PMID:9755169 - Cdc18 transcription and proteolysis couple S phase to passage through mitosis.

Baum B et al. EMBO J 1998 Oct 01;17(19):5689-98

PMID:9034336 - Fission yeast pheromone blocks S-phase by inhibiting the G1 cyclin B-p34cdc2 kinase.

Stern B et al. EMBO J 1997 Feb 03;16(3):534-44

PMID:9398669 - A WD repeat protein controls the cell cycle and differentiation by negatively regulating Cdc2/B-type cyclin complexes.

Yamaguchi S et al. Mol Biol Cell 1997 Dec;8(12):2475-86

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:12093738 - G(1)/S CDK is inhibited to restrain mitotic onset when DNA replication is blocked in fission yeast.

Zarzov P et al. EMBO J 2002 Jul 01;21(13):3370-6

PMID:23322785 - The fission yeast minichromosome maintenance (MCM)-binding protein (MCM-BP), Mcb1, regulates MCM function during prereplicative complex formation in DNA replication.

Santosa V et al. J Biol Chem 2013 Mar 08;288(10):6864-80

PMID:18059475 - Cdc2p controls the forkhead transcription factor Fkh2p by phosphorylation during sexual differentiation in fission yeast.

Shimada M et al. EMBO J 2008 Jan 09;27(1):132-42

PMID:29084823 - Phosphorylation of the RNA-binding protein Zfs1 modulates sexual differentiation in fission yeast.

Navarro FJ et al. J Cell Sci 2017 Dec 15;130(24):4144-4154

PMID:30647105 - Comparative Genomic Screen in Two Yeasts Reveals Conserved Pathways in the Response Network to Phenol Stress.

Alhoch B et al. G3 (Bethesda) 2019 Mar 07;9(3):639-650

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:10388806 - Rereplication phenomenon in fission yeast requires MCM proteins and other S phase genes.

Snaith HA et al. Genetics 1999 Jul;152(3):839-51

PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.

Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6

PMID:9614176 - Cyclin B proteolysis and the cyclin-dependent kinase inhibitor rum1p are required for pheromone-induced G1 arrest in fission yeast.

Stern B et al. Mol Biol Cell 1998 Jun;9(6):1309-21

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:10921876 - APC(ste9/srw1) promotes degradation of mitotic cyclins in G(1) and is inhibited by cdc2 phosphorylation.

Blanco MA et al. EMBO J 2000 Aug 01;19(15):3945-55

PMID:11683390 - In vivo localisation of fission yeast cyclin-dependent kinase cdc2p and cyclin B cdc13p during mitosis and meiosis.

Decottignies A et al. J Cell Sci 2001 Jul;114(Pt 14):2627-40

PMID:11781565 - Feedback regulation of the MBF transcription factor by cyclin Cig2.

Ayté J et al. Nat Cell Biol 2001 Dec;3(12):1043-50

PMID:16024772 - A meiosis-specific cyclin regulated by splicing is required for proper progression through meiosis.

Malapeira J et al. Mol Cell Biol 2005 Aug;25(15):6330-7

PMID:16615890 - Meiotic proteins bqt1 and bqt2 tether telomeres to form the bouquet arrangement of chromosomes.

Chikashige Y et al. Cell 2006 Apr 07;125(1):59-69

PMID:19714215 - The fission yeast homeodomain protein Yox1p binds to MBF and confines MBF-dependent cell-cycle transcription to G1-S via negative feedback.

Aligianni S et al. PLoS Genet 2009 Aug;5(8):e1000626

PMID:8455610 - Two fission yeast B-type cyclins, cig2 and Cdc13, have different functions in mitosis.

Bueno A et al. Mol Cell Biol 1993 Apr;13(4):2286-97

PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.

Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399

PMID:8657126 - Cig2, a B-type cyclin, promotes the onset of S in Schizosaccharomyces pombe.

Mondesert O et al. Mol Cell Biol 1996 Apr;16(4):1527-33

PMID:26804917 - Spatiotemporal Control of Forkhead Binding to DNA Regulates the Meiotic Gene Expression Program.

Alves-Rodrigues I et al. Cell Rep 2016 Feb 02;14(4):885-895

PMID:11163211 - The spike of S phase cyclin Cig2 expression at the G1-S border in fission yeast requires both APC and SCF ubiquitin ligases.

Yamano H et al. Mol Cell 2000 Dec;6(6):1377-87

PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.

Strachan J et al. J Cell Sci 2023 Dec 01;136(23)

PMID:32361273 - Requirement of PP2A-B56 Par1 for the Stabilization of the CDK Inhibitor Rum1 and Activation of APC/C Ste9 during Pre-Start G1 in S. pombe.

Stonyte V et al. iScience 2020 May 22;23(5):101063

PMID:10582241 - Control of metaphase-anaphase progression by proteolysis: cyclosome function regulated by the protein kinase A pathway, ubiquitination and localization.

Yanagida M et al. Philos Trans R Soc Lond B Biol Sci 1999 Sep 29;354(1389):1559-69; discussion 1569-70

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87

PMID:14970237 - Requirement of the SCFPop1/Pop2 Ubiquitin Ligase for Degradation of the Fission Yeast S Phase Cyclin Cig2.

Yamano H et al. J Biol Chem 2004 Apr 30;279(18):18974-80

PMID:8972180 - Roles of Wee1 and Nim1 protein kinases in regulating the switch from mitotic division to sexual development in Schizosaccharomyces pombe.

Wu L et al. Mol Cell Biol 1997 Jan;17(1):10-7

PMID:9430640 - Regulation of the G1 phase of the cell cycle by periodic stabilization and degradation of the p25rum1 CDK inhibitor.

Benito J et al. EMBO J 1998 Jan 15;17(2):482-97

PMID:15791259 - Fission yeast Mes1p ensures the onset of meiosis II by blocking degradation of cyclin Cdc13p.

Izawa D et al. Nature 2005 Mar 24;434(7032):529-33

PMID:9571240 - Fission yeast Ste9, a homolog of Hct1/Cdh1 and Fizzy-related, is a novel negative regulator of cell cycle progression during G1-phase.

Kitamura K et al. Mol Biol Cell 1998 May;9(5):1065-80

PMID:10982385 - A pcl-like cyclin activates the Res2p-Cdc10p cell cycle "start" transcriptional factor complex in fission yeast.

Tanaka K et al. Mol Biol Cell 2000 Sep;11(9):2845-62

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:18474252 - Crosstalk between Nap1 protein and Cds1 checkpoint kinase to maintain chromatin integrity.

Grande M et al. Biochim Biophys Acta 2008 Sep;1783(9):1595-604

PMID:30640914 - CDK contribution to DSB formation and recombination in fission yeast meiosis.

Bustamante-Jaramillo LF et al. PLoS Genet 2019 Jan;15(1):e1007876

PMID:12960401 - Intra-G1 arrest in response to UV irradiation in fission yeast.

Nilssen EA et al. Proc Natl Acad Sci U S A 2003 Sep 16;100(19):10758-63

PMID:15194812 - A novel intermediate in initiation complex assembly for fission yeast DNA replication.

Yamada Y et al. Mol Biol Cell 2004 Aug;15(8):3740-50

PMID:8631306 - A single fission yeast mitotic cyclin B p34cdc2 kinase promotes both S-phase and mitosis in the absence of G1 cyclins.

Fisher DL et al. EMBO J 1996 Feb 15;15(4):850-60

PMID:9303312 - Control of S-phase periodic transcription in the fission yeast mitotic cycle.

Baum B et al. EMBO J 1997 Aug 01;16(15):4676-88

PMID:9552380 - Regulation of G1 progression in fission yeast by the rum1+ gene product.

Martín-Castellanos C et al. Prog Cell Cycle Res 1996;2:29-35

PMID:9177184 - Interaction of the S phase regulator cdc18 with cyclin-dependent kinase in fission yeast.

Brown GW et al. Proc Natl Acad Sci U S A 1997 Jun 10;94(12):6142-7

PMID:34067465 - The Meiosis-Specific Crs1 Cyclin Is Required for Efficient S-Phase Progression and Stable Nuclear Architecture.

Bustamante-Jaramillo LF et al. Int J Mol Sci 2021 May 22;22(11)

PMID:11937031 - CDK phosphorylation of Drc1 regulates DNA replication in fission yeast.

Noguchi E et al. Curr Biol 2002 Apr 02;12(7):599-605

PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.

Skribbe M et al. Mol Cell 2025 Feb 19;

PMID:25891897 - A single cyclin-CDK complex is sufficient for both mitotic and meiotic progression in fission yeast.

Gutiérrez-Escribano P et al. Nat Commun 2015 Apr 20;6:6871

PMID:9353247 - Regulation of the replication initiator protein p65cdc18 by CDK phosphorylation.

Jallepalli PV et al. Genes Dev 1997 Nov 01;11(21):2767-79

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:9736616 - Apc10 and Ste9/Srw1, two regulators of the APC-cyclosome, as well as the CDK inhibitor Rum1 are required for G1 cell-cycle arrest in fission yeast.

Kominami K et al. EMBO J 1998 Sep 15;17(18):5388-99

PMID:10779336 - Fission yeast Eso1p is required for establishing sister chromatid cohesion during S phase.

Tanaka K et al. Mol Cell Biol 2000 May;20(10):3459-69

PMID:10679013 - The puc1 cyclin regulates the G1 phase of the fission yeast cell cycle in response to cell size.

Martín-Castellanos C et al. Mol Biol Cell 2000 Feb;11(2):543-54

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:9447985 - Novel factor highly conserved among eukaryotes controls sexual development in fission yeast.

Okazaki N et al. Mol Cell Biol 1998 Feb;18(2):887-95

PMID:25533348 - Tolerance of deregulated G1/S transcription depends on critical G1/S regulon genes to prevent catastrophic genome instability.

Caetano C et al. Cell Rep 2014 Dec 24;9(6):2279-89

PMID:9671458 - An RNA binding protein negatively controlling differentiation in fission yeast.

Tsukahara K et al. Mol Cell Biol 1998 Aug;18(8):4488-98

PMID:33683349 - The fission yeast S-phase cyclin Cig2 can drive mitosis.

Pickering M et al. Genetics 2021 Mar 03;217(1):1-12

PMID:17531813 - Cdc18 enforces long-term maintenance of the S phase checkpoint by anchoring the Rad3-Rad26 complex to chromatin.

Hermand D et al. Mol Cell 2007 May 25;26(4):553-63

PMID:19487461 - Cyclin-dependent kinase inhibits reinitiation of a normal S-phase program during G2 in fission yeast.

Kiang L et al. Mol Cell Biol 2009 Aug;29(15):4025-32