protein coding gene - vma5 (SPAPB2B4.05) - V-type ATPase V1 subunit C

Gene summary

Standard name: vma5
Systematic ID: SPAPB2B4.05
Product: V-type ATPase V1 subunit C
Organism: Schizosaccharomyces pombe (fission yeast)
UniProt ID: Q9HDW6
Characterisation status: biological role inferred
Feature type: mRNA gene
Genomic location: chromosome I: 2720815..2722630 forward strand

Annotation

GO biological process

GO:1902600 - proton transmembrane transport

References:

GO_REF:0000111

GO:0007035 - vacuolar acidification

References:

PMID:16291725

GO cellular component

GO:0005829 - cytosol

References:

PMID:16823372

GO:0000221 - vacuolar proton-transporting V-type ATPase, V1 domain

References:

GO_REF:0000033

GO molecular function

GO:0016887 - ATP hydrolysis activity

References:

GO_REF:0000111

GO:0046961 - proton-transporting ATPase activity, rotational mechanism

References:

GO_REF:0000033

Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:01148 - ubiquitinylated lysine

References:

PMID:37970674

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

PMID:23101633

Single locus phenotype

FYPO:0001042 - inviable after spore germination, single or double cell division

References:

PMID:23697806

Genotypes:

vma5delta

FYPO:0000310 - inviable after spore germination, without cell division, with normal germ tube morphology

References:

PMID:23697806

Genotypes:

vma5delta

FYPO:0002151 - inviable spore

References:

PMID:23697806

Genotypes:

vma5delta

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

vma5delta

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

ID	Name	InterPro name	DB name
PF03223	V-ATPase_C	ATPase_V1-cplx_csu	PFAM
cd14785	V-ATPase_C	ATPase_V1-cplx_csu	CDD
G3DSA:3.30.70.100:FF:000002			FUNFAM
SSF118203	Vacuolar ATP synthase subunit C	Vac_ATP_synth_c_sf	SUPERFAMILY
G3DSA:3.30.70.100			GENE3D
G3DSA:3.30.70.1180	Vacuolar atp synthase subunit c; domain 1		GENE3D
G3DSA:1.20.1460.10			GENE3D
PTHR10137	V-TYPE PROTON ATPASE SUBUNIT C	ATPase_V1-cplx_csu	PANTHER

Orthologs

ATP6V1C2 (HGNC:18264) Homo sapiens
ATP6V1C1 (HGNC:856) Homo sapiens
vma5 (SJAG_01397) Schizosaccharomyces japonicus
VMA5 (YKL080W) Saccharomyces cerevisiae

References / Literature

PMID:28947618 - Sde2 is an intron-specific pre-mRNA splicing regulator activated by ubiquitin-like processing.: Thakran P et al. EMBO J 2018 Jan 04;37(1):89-101
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.: Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:16291725 - btn1, the Schizosaccharomyces pombe homologue of the human Batten disease gene CLN3, regulates vacuole homeostasis.: Gachet Y et al. J Cell Sci 2005 Dec 01;118(Pt 23):5525-36
PMID:18257517 - Phosphoproteome analysis of fission yeast.: Wilson-Grady JT et al. J Proteome Res 2008 Mar;7(3):1088-97
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.: Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:20118936 - Schizosaccharomyces pombe genome-wide nucleosome mapping reveals positioning mechanisms distinct from those of Saccharomyces cerevisiae.: Lantermann AB et al. Nat Struct Mol Biol 2010 Feb;17(2):251-7
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.: Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.: Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.: Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.: Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.: Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).: Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.: Halova L et al. Open Biol 2021 Apr;11(4):200405
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.: Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.: Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895
PMID:21511999 - Comparative functional genomics of the fission yeasts.: Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83