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protein coding gene - pfl10 (SPAPB2C8.01) - cell surface glycoprotein, adhesion molecule Pfl10

Gene summary

Standard name
pfl10
Systematic ID
SPAPB2C8.01
Product
cell surface glycoprotein, adhesion molecule Pfl10
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q9C0Y2
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome I: 2942320..2946190 forward strand

Annotation

GO biological process

GO:0098609 - cell-cell adhesion

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GO cellular component

GO:0070263 - external side of fungal-type cell wall

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GO molecular function

GO:0098632 - cell-cell adhesion mediator activity

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Miscellaneous functional group

PBO:0000068 - cell surface glycoprotein

Modification

MOD:00693 - glycosylated residue

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MOD:00006 - N-glycosylated residue

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Protein features

PBO:0111742 - GLEYA domain

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Protein sequence feature

SO:0000418 - signal_peptide

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Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

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PomGeneEx:0000018 - protein level increased

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Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000031 - abnormal mating

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Genotypes:

FYPO:0004806 - incomplete cell wall disassembly at cell fusion site

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Genotypes:

FYPO:0000245 - loss of viability in stationary phase

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Genotypes:

FYPO:0009079 - resistance to calcofluor and sodium dodecyl sulfate

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Genotypes:

FYPO:0005969 - resistance to magnesium chloride

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Genotypes:

FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0005193 - resistance to torin1

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Genotypes:

FYPO:0000799 - sensitive to diamide

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Genotypes:

FYPO:0007931 - sensitive to egtazic acid

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Genotypes:

FYPO:0009086 - sensitive to lithium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0000797 - sensitive to tert-butyl hydroperoxide

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0011064 - conserved in fungi

PBO:0011063 - conserved in fungi only

PBO:0000055 - no apparent S. cerevisiae ortholog

Warnings

PBO:0091431 - 3 kb of 36 amino acid repeat

Protein features

IDNameInterPro nameDB name
PF10528GLEYAGLEYA_adhesin_domainPFAM
PS51820PA14PA14/GLEYAPROSITE_PROFILES
SSF50978WD40 repeat-likeWD40_repeat_dom_sfSUPERFAMILY
SSF51004C-terminal (heme d1) domain of cytochrome cd1-nitrite reductaseHaem_d1_sfSUPERFAMILY
G3DSA:2.130.10.10WD40/YVTN_repeat-like_dom_sfGENE3D
PTHR31492M CELL-TYPE AGGLUTINATION PROTEIN MAM3-RELATEDS_pombe_Mam3/Map4PANTHER

Orthologs

References / Literature

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:17870620 - Molecular phylogenetics of ascomycotal adhesins--a novel family of putative cell-surface adhesive proteins in fission yeasts.
Linder T et al. Fungal Genet Biol 2008 Apr;45(4):485-97
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
GO_REF:0000050 - Manual transfer of GO annotation data to genes by curator judgment of sequence model
PMID:29259000 - Genes Important for Schizosaccharomyces pombe Meiosis Identified Through a Functional Genomics Screen.
Blyth J et al. Genetics 2018 Feb;208(2):589-603
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:35820914 - Antagonistic effects of mitochondrial matrix and intermembrane space proteases on yeast aging.
Vega M et al. BMC Biol 2022 Jul 12;20(1):160
PMID:22633491 - Mapping N-glycosylation sites across seven evolutionarily distant species reveals a divergent substrate proteome despite a common core machinery.
Zielinska DF et al. Mol Cell 2012 May 25;46(4):542-8
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:26896847 - Ensembl comparative genomics resources.
Herrero J et al. Database (Oxford) 2016;2016
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:28410370 - A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.
Dudin O et al. PLoS Genet 2017 Apr;13(4):e1006721