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protein coding gene - mfm1 (SPAPB8E5.05) - M-factor precursor Mfm1

Gene summary

Standard name
mfm1
Systematic ID
SPAPB8E5.05
Product
M-factor precursor Mfm1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
P34068
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 4917015..4917521 forward strand

Annotation

Comment

PBO:0012837 - mature peptide sequence is YTPKVPYM

GO biological process

GO:0007267 - cell-cell signaling

References:

GO:0062038 - positive regulation of pheromone response MAPK cascade

References:

GO cellular component

GO:0005576 - extracellular region

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GO molecular function

GO:0000772 - mating pheromone activity

References:

Modification

MOD:00114 - L-cysteine methyl ester

References:

MOD:00660 - methylated cysteine

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MOD:00111 - S-farnesyl-L-cysteine

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Multi-locus phenotype

FYPO:0000708 - decreased mating efficiency

References:

Genotypes:

FYPO:0003847 - h- specific sterility

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Genotypes:

FYPO:0000280 - sterile

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Genotypes:

Protein sequence feature

SO:0100011 - cleaved_peptide_region

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Qualitative gene expression

PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0002003 - abolished RNA polymerase II proximal promoter sequence-specific DNA binding

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Genotypes:

FYPO:0005118 - decreased transcription during nitrogen starvation

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Genotypes:

FYPO:0004806 - incomplete cell wall disassembly at cell fusion site

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Genotypes:

FYPO:0009094 - increased cell population growth on lysine and proline nitrogen source

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Genotypes:

FYPO:0000636 - increased cell population growth rate

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Genotypes:

FYPO:0004557 - increased vegetative cell population growth

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Genotypes:

FYPO:0001147 - normal mating efficiency

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Genotypes:

FYPO:0009038 - resistance to egtazic acid

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Genotypes:

FYPO:0001453 - resistance to ethanol

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Genotypes:

FYPO:0001583 - resistance to lithium

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Genotypes:

FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0003383 - resistance to tert-butyl hydroperoxide

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Genotypes:

FYPO:0000799 - sensitive to diamide

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0016878 - Schizosaccharomyces pombe specific

Protein features

IDNameInterPro nameDB name
PF03855M-factorM-factorPFAM
mobidb-lite-Disorderdisorder_predictionMOBIDB-Disorder

References / Literature

PMID:8380233 - Schizosaccharomyces pombe map3+ encodes the putative M-factor receptor.
Tanaka K et al. Mol Cell Biol 1993 Jan;13(1):80-8
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.
Mata J et al. Nat Genet 2002 Sep;32(1):143-7
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:38899862 - Suppression of inositol pyrophosphate toxicosis and hyper-repression of the fission yeast PHO regulon by loss-of-function mutations in chromatin remodelers Snf22 and Sol1.
Schwer B et al. mBio 2024 Jun 20;:e0125224
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:7900424 - Assessment of pheromone production and response in fission yeast by a halo test of induced sporulation.
Egel R et al. Yeast 1994 Oct;10(10):1347-54
PMID:9191271 - Isolation of yeast mutants hypersensitive to mating pheromones.
Davis K et al. Biochem Soc Trans 1997 May;25(2):227S
PMID:19714215 - The fission yeast homeodomain protein Yox1p binds to MBF and confines MBF-dependent cell-cycle transcription to G1-S via negative feedback.
Aligianni S et al. PLoS Genet 2009 Aug;5(8):e1000626
PMID:15713656 - Constitutive activation of the fission yeast pheromone-responsive pathway induces ectopic meiosis and reveals ste11 as a mitogen-activated protein kinase target.
Kjaerulff S et al. Mol Cell Biol 2005 Mar;25(5):2045-59
PMID:9233811 - Cell differentiation by interaction of two HMG-box proteins: Mat1-Mc activates M cell-specific genes in S.pombe by recruiting the ubiquitous transcription factor Ste11 to weak binding sites.
Kjaerulff S et al. EMBO J 1997 Jul 01;16(13):4021-33
PMID:39094565 - Mapping the dynamics of epigenetic adaptation in S. pombe during heterochromatin misregulation.
Larkin A et al. Dev Cell 2024 Jul 26;
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:8196631 - Analysis of the structural genes encoding M-factor in the fission yeast Schizosaccharomyces pombe: identification of a third gene, mfm3.
Kjaerulff S et al. Mol Cell Biol 1994 Jun;14(6):3895-905
PMID:32896087 - Mitochondrial respiration is required to provide amino acids during fermentative proliferation of fission yeast.
Malecki M et al. EMBO Rep 2020 Nov 05;21(11):e50845
PMID:9032282 - Genes encoding farnesyl cysteine carboxyl methyltransferase in Schizosaccharomyces pombe and Xenopus laevis.
Imai Y et al. Mol Cell Biol 1997 Mar;17(3):1543-51
PMID:28410370 - A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.
Dudin O et al. PLoS Genet 2017 Apr;13(4):e1006721
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;
PMID:25831518 - Molecular coevolution of a sex pheromone and its receptor triggers reproductive isolation in Schizosaccharomyces pombe.
Seike T et al. Proc Natl Acad Sci U S A 2015 Apr 07;112(14):4405-10
PMID:9236781 - The Schizosaccharomyces pombe mam1 gene encodes an ABC transporter mediating secretion of M-factor.
Christensen PU et al. Mol Gen Genet 1997 Jun;255(2):226-36
PMID:25452419 - Parallel profiling of fission yeast deletion mutants for proliferation and for lifespan during long-term quiescence.
Sideri T et al. G3 (Bethesda) 2014 Dec 01;5(1):145-55
PMID:9388671 - Proteases involved in the maturation of the M-factor mating pheromone in fission yeast.
Hughes M et al. Biochem Soc Trans 1997 Aug;25(3):447S
PMID:7651414 - Two-step activation of meiosis by the mat1 locus in Schizosaccharomyces pombe.
Willer M et al. Mol Cell Biol 1995 Sep;15(9):4964-70
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:12501333 - Induction of sexual co-flocculation of heterothallic fission yeast (Schizosaccharomyces pombe) cells by mating pheromones.
Miyata M et al. J Gen Appl Microbiol 1997 Jun;43(3):169-174
PMID:24957674 - Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts.
Anver S et al. EMBO Rep 2014 Aug;15(8):894-902
PMID:1547790 - Mating pheromones of the fission yeast Schizosaccharomyces pombe: purification and structural characterization of M-factor and isolation and analysis of two genes encoding the pheromone.
Davey J EMBO J 1992 Mar;11(3):951-60
PMID:16288715 - Alternative protein secretion: the Mam1 ABC transporter supports secretion of M-factor linked GFP in fission yeast.
Kjaerulff S et al. Biochem Biophys Res Commun 2005 Dec 30;338(4):1853-9