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protein coding gene - pro3 (SPAPYUG7.05) - delta-1-pyrroline-5-carboxylate reductase Pro3

Gene summary

Standard name
pro3
Systematic ID
SPAPYUG7.05
Product
delta-1-pyrroline-5-carboxylate reductase Pro3
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q9P7Y7
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome I: 4752711..4753912 forward strand

Annotation

Disease association

MONDO:0013051 - autosomal recessive cutis laxa type 2B

References:

MONDO:0014632 - leukodystrophy, hypomyelinating, 10

References:

MONDO:0013755 - PYCR1-related de Barsy syndrome

References:

GO biological process

GO:0055129 - L-proline biosynthetic process

References:

GO cellular component

GO:0005829 - cytosol

References:

GO molecular function

GO:0004735 - pyrroline-5-carboxylate reductase activity

References:

Modification

MOD:01148 - ubiquitinylated lysine

References:

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

References:

PomGeneEx:0000012 - RNA level decreased

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Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000059 - abnormal mitotic cell cycle

References:

Genotypes:

FYPO:0003529 - inviable after spore germination, multiple cell divisions, cell cycle arrest in mitotic interphase, elongated cells

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011072 - conserved in archaea

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF03807F420_oxidoredP5C_Rdtase_cat_NPfam
PF14748P5CR_dimerP5CR_dimerPfam
PS00521P5CRP5CR-like_CSPROSITE patterns
G3DSA:1.10.3730.10:FF:000001CATH-FunFam
G3DSA:1.10.3730.10CATH-Gene3D
G3DSA:3.40.50.720CATH-Gene3D
SSF481796-PGluconate_DH-like_C_sfSUPERFAMILY
SSF51735NAD(P)-bd_dom_sfSUPERFAMILY
PTHR11645PANTHER
PIRSF000193Pyrrol-5-carb_rdPyrroline-COOH_reductasePIRSF
TIGR00112proCPyrroline-COOH_reductaseNCBIFAM
MF_01925P5C_reductasePyrroline-COOH_reductaseHAMAP

Orthologs

References / Literature

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.
Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)