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tRNA gene - SPATRNALYS.02 - tRNA Lysine

Gene summary

Systematic ID
SPATRNALYS.02
Product
tRNA Lysine
Organism
Schizosaccharomyces pombe (fission yeast)
Feature type
tRNA gene
Genomic location
chromosome I: 1733764..1733838 reverse strand

Annotation

GO biological process

GO:0002182 - cytoplasmic translational elongation

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GO cellular component

GO:0005737 - cytoplasm

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GO molecular function

GO:0033443 - AAA codon-amino acid adaptor activity

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Multi-locus phenotype

FYPO:0001324 - decreased protein level during vegetative growth

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Genotypes:

FYPO:0000674 - normal cell population growth at high temperature

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Genotypes:

FYPO:0002360 - normal chromatin silencing at centromere

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Genotypes:

FYPO:0002672 - normal growth on rapamycin

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Genotypes:

FYPO:0003503 - normal vegetative cell length

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Genotypes:

Quantitative gene expression

PBO:0011963 - RNA level

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References / Literature

PMID:22768388 - Translational control of cell division by Elongator.
Bauer F et al. Cell Rep 2012 May 31;1(5):424-33
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
GO_REF:0000050 - Manual transfer of GO annotation data to genes by curator judgment of sequence model
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:23874237 - Modification of tRNA(Lys) UUU by elongator is essential for efficient translation of stress mRNAs.
Fernández-Vázquez J et al. PLoS Genet 2013;9(7):e1003647
PMID:18391219 - The conserved Wobble uridine tRNA thiolase Ctu1-Ctu2 is required to maintain genome integrity.
Dewez M et al. Proc Natl Acad Sci U S A 2008 Apr 08;105(14):5459-64
PMID:28775286 - Elp3 and Dph3 of Schizosaccharomyces pombe mediate cellular stress responses through tRNA Lys UUU modifications.
Villahermosa D et al. Sci Rep 2017 Aug 03;7(1):7225