protein coding gene - pka1 (SPBC106.10) - cAMP-dependent protein kinase catalytic subunit Pka1

Gene summary

Standard name

pka1

Systematic ID

SPBC106.10

Product

cAMP-dependent protein kinase catalytic subunit Pka1

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

tpk, git6, sam1, sam5, sam6, sam7, sam2, sam8

UniProt ID

P40376

ORFeome ID

24/24H10

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome II: 396992..398957 forward strand

Annotation

Protein features

Orthologs

• PRKACA (HGNC:9380) Homo sapiens
• PRKACB (HGNC:9381) Homo sapiens
• PRKACG (HGNC:9382) Homo sapiens
• PRKX (HGNC:9441) Homo sapiens
• pka1 (SJAG_04312) Schizosaccharomyces japonicus
• TPK1 (YJL164C) Saccharomyces cerevisiae
• TPK3 (YKL166C) Saccharomyces cerevisiae
• TPK2 (YPL203W) Saccharomyces cerevisiae

References / Literature

PMID:35286199 - Mitotic spindle formation in the absence of Polo kinase.

Kim J et al. Proc Natl Acad Sci U S A 2022 Mar 22;119(12):e2114429119

PMID:10982411 - A zinc-finger protein, Rst2p, regulates transcription of the fission yeast ste11(+) gene, which encodes a pivotal transcription factor for sexual development.

Kunitomo H et al. Mol Biol Cell 2000 Sep;11(9):3205-17

PMID:29316864 - Overexpression of the transcription factor Rst2 in Schizosaccharomyces pombe indicates growth defect, mitotic defects, and microtubule disorder.

Takenaka K et al. Biosci Biotechnol Biochem 2018 Feb;82(2):247-257

PMID:27053105 - Mga2 Transcription Factor Regulates an Oxygen-responsive Lipid Homeostasis Pathway in Fission Yeast.

Burr R et al. J Biol Chem 2016 Jun 03;291(23):12171-83

PMID:12618370 - Schizosaccharomyces pombe essential genes: a pilot study.

Decottignies A et al. Genome Res 2003 Mar;13(3):399-406

PMID:31626996 - Multiplexed proteome profiling of carbon source perturbations in two yeast species with SL-SP3-TMT.

Paulo JA et al. J Proteomics 2020 Jan 06;210:103531

PMID:11238405 - Transcriptional regulators of the Schizosaccharomyces pombe fbp1 gene include two redundant Tup1p-like corepressors and the CCAAT binding factor activation complex.

Janoo RT et al. Genetics 2001 Mar;157(3):1205-15

PMID:1849107 - Glucose repression of transcription of the Schizosaccharomyces pombe fbp1 gene occurs by a cAMP signaling pathway.

Hoffman CS et al. Genes Dev 1991 Apr;5(4):561-71

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:18422613 - A novel gene, ecl1(+), extends the chronological lifespan in fission yeast.

Ohtsuka H et al. FEMS Yeast Res 2008 Jun;8(4):520-30

PMID:38598031 - Pps1, phosphatidylserine synthase, regulates the salt stress response in Schizosaccharomyces pombe.

Naozuka G et al. Mol Genet Genomics 2024 Apr 10;299(1):43

PMID:17261596 - Loss of the TOR kinase Tor2 mimics nitrogen starvation and activates the sexual development pathway in fission yeast.

Matsuo T et al. Mol Cell Biol 2007 Apr;27(8):3154-64

PMID:19584544 - Identification of sam4 as a rad24 allele in Schizosaccharomyces pombe.

Oowatari Y et al. Biosci Biotechnol Biochem 2009 Jul;73(7):1591-8

PMID:22976295 - Psk1, an AGC kinase family member in fission yeast, is directly phosphorylated and controlled by TORC1 and functions as S6 kinase.

Nakashima A et al. J Cell Sci 2012 Dec 01;125(Pt 23):5840-9

PMID:25102102 - A metabolic strategy to enhance long-term survival by Phx1 through stationary phase-specific pyruvate decarboxylases in fission yeast.

Kim JY et al. Aging (Albany NY) 2014 Jul;6(7):587-601

PMID:24155978 - Possible involvement of nitric oxide and reactive oxygen species in glucose deprivation-induced activation of transcription factor rst2.

Kato T et al. PLoS One 2013;8(10):e78012

PMID:20075862 - Lifespan extension by calorie restriction relies on the Sty1 MAP kinase stress pathway.

Zuin A et al. EMBO J 2010 Mar 03;29(5):981-91

PMID:28264193 - Substrate specificity of TOR complex 2 is determined by a ubiquitin-fold domain of the Sin1 subunit.

Tatebe H et al. Elife 2017 Mar 07;6

PMID:33400299 - Role of mitochondrial complex III/IV in the activation of transcription factor Rst2 in Schizosaccharomyces pombe.

Jiang G et al. Mol Microbiol 2021 Jun;115(6):1323-1338

PMID:31562247 - Glucose starvation induces mitochondrial fragmentation depending on the dynamin GTPase Dnm1/Drp1 in fission yeast.

Zheng F et al. J Biol Chem 2019 Nov 22;294(47):17725-17734

PMID:9264466 - Distinct subunit functions and cell cycle regulated phosphorylation of 20S APC/cyclosome required for anaphase in fission yeast.

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PMID:30647105 - Comparative Genomic Screen in Two Yeasts Reveals Conserved Pathways in the Response Network to Phenol Stress.

Alhoch B et al. G3 (Bethesda) 2019 Mar 07;9(3):639-650

PMID:16550352 - A starvation-specific serine protease gene, isp6+, is involved in both autophagy and sexual development in Schizosaccharomyces pombe.

Nakashima A et al. Curr Genet 2006 Jun;49(6):403-13

PMID:2157626 - Isolation and characterization of mutants constitutive for expression of the fbp1 gene of Schizosaccharomyces pombe.

Hoffman CS et al. Genetics 1990 Apr;124(4):807-16

PMID:36107819 - cAMP-Protein kinase A and stress-activated MAP kinase signaling mediate transcriptional control of autophagy in fission yeast during glucose limitation or starvation.

Pérez-Díaz AJ et al. Autophagy 2023 Apr;19(4):1311-1331

PMID:15821139 - Systematic deletion analysis of fission yeast protein kinases.

Bimbó A et al. Eukaryot Cell 2005 Apr;4(4):799-813

PMID:7498728 - sck1, a high copy number suppressor of defects in the cAMP-dependent protein kinase pathway in fission yeast, encodes a protein homologous to the Saccharomyces cerevisiae SCH9 kinase.

Jin M et al. Genetics 1995 Jun;140(2):457-67

PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.

Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963

PMID:8552099 - Schizosaccharomyces pombe pcr1+ encodes a CREB/ATF protein involved in regulation of gene expression for sexual development.

Watanabe Y et al. Mol Cell Biol 1996 Feb;16(2):704-11

PMID:34984977 - Functional profiling of long intergenic non-coding RNAs in fission yeast.

Rodriguez-Lopez M et al. Elife 2022 Jan 05;11

PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.

Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399

PMID:30973898 - Mal3 is a multi-copy suppressor of the sensitivity to microtubule-depolymerizing drugs and chromosome mis-segregation in a fission yeast pka1 mutant.

Tanabe T et al. PLoS One 2019;14(4):e0214803

PMID:16861909 - Fission yeast MAP kinase is required for the increased securin-separase interaction that rescues separase mutants under stresses.

Kawasaki Y et al. Cell Cycle 2006 Aug;5(16):1831-9

PMID:28513584 - Kinesin-5-independent mitotic spindle assembly requires the antiparallel microtubule crosslinker Ase1 in fission yeast.

Rincon SA et al. Nat Commun 2017 May 17;8:15286

PMID:11014802 - Glucose monitoring in fission yeast via the Gpa2 galpha, the git5 Gbeta and the git3 putative glucose receptor.

Welton RM et al. Genetics 2000 Oct;156(2):513-21

PMID:8227198 - Six git genes encode a glucose-induced adenylate cyclase activation pathway in the fission yeast Schizosaccharomyces pombe.

Byrne SM et al. J Cell Sci 1993 Aug;105 ( Pt 4)(0 4):1095-100

PMID:9372444 - A zinc finger protein required for stationary phase viability in fission yeast.

Hao Z et al. J Cell Sci 1997 Oct;110 ( Pt 20):2557-66

PMID:35171902 - The cAMP signaling pathway regulates Epe1 protein levels and heterochromatin assembly.

Bao K et al. PLoS Genet 2022 Feb;18(2):e1010049

PMID:9302019 - Trehalose synthesis is important for the acquisition of thermotolerance in Schizosaccharomyces pombe.

Ribeiro MJ et al. Mol Microbiol 1997 Aug;25(3):571-81

PMID:18410345 - Characterization of Sro1, a novel stress responsive protein in Schizosaccharomyces pombe.

Sundaram G et al. FEMS Yeast Res 2008 Jun;8(4):564-73

PMID:34086083 - Expression of Mug14 is regulated by the transcription factor Rst2 through the cAMP-dependent protein kinase pathway in Schizosaccharomyces pombe.

Inamura SI et al. Curr Genet 2021 Oct;67(5):807-821

PMID:18257517 - Phosphoproteome analysis of fission yeast.

Wilson-Grady JT et al. J Proteome Res 2008 Mar;7(3):1088-97

PMID:20453258 - Living on the edge: stress and activation of stress responses promote lifespan extension.

Zuin A et al. Aging (Albany NY) 2010 Apr;2(4):231-7

PMID:19266076 - Pro-aging effects of glucose signaling through a G protein-coupled glucose receptor in fission yeast.

Roux AE et al. PLoS Genet 2009 Mar;5(3):e1000408

PMID:11872168 - Genes for a nuclease and a protease are involved in the drastic decrease in cellular RNA amount in fission yeast cells during nitrogen starvation.

Nakashima A et al. J Biochem 2002 Mar;131(3):391-8

PMID:23640764 - Phosphorylations of Sds23/Psp1/Moc1 by stress-activated kinase and cAMP-dependent kinase are essential for regulating cell viability in prolonged stationary phase.

Jang YJ et al. Yeast 2013 Oct;30(10):379-94

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87

PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Lee J et al. Nat Commun 2017 Feb 20;8:14527

PMID:21879336 - Multistep regulation of protein kinase A in its localization, phosphorylation and binding with a regulatory subunit in fission yeast.

Gupta DR et al. Curr Genet 2011 Oct;57(5):353-65

PMID:32441227 - Glucose limitation and pka1 deletion rescue aberrant mitotic spindle formation induced by Mal3 overexpression in Schizosaccharomyces pombe .

Tanabe T et al. Biosci Biotechnol Biochem 2020 Aug;84(8):1667-1680

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:25452419 - Parallel profiling of fission yeast deletion mutants for proliferation and for lifespan during long-term quiescence.

Sideri T et al. G3 (Bethesda) 2014 Dec 01;5(1):145-55

PMID:28357272 - A central role for TOR signalling in a yeast model for juvenile CLN3 disease.

Bond ME et al. Microb Cell 2015 Nov 11;2(12):466-480

PMID:7828877 - The Schizosaccharomyces pombe pka1 gene, encoding a homolog of cAMP-dependent protein kinase.

Yu G et al. Gene 1994 Dec 30;151(1-2):215-20

PMID:15611161 - In vivo activation of protein kinase A in Schizosaccharomyces pombe requires threonine phosphorylation at its activation loop and is dependent on PDK1.

Tang Y et al. Genetics 2004 Dec;168(4):1843-53

PMID:24928510 - Glucose activates TORC2-Gad8 protein via positive regulation of the cAMP/cAMP-dependent protein kinase A (PKA) pathway and negative regulation of the Pmk1 protein-mitogen-activated protein kinase pathway.

Cohen A et al. J Biol Chem 2014 Aug 01;289(31):21727-37

PMID:33829153 - cAMP export by the fission yeast Schizosaccharomyces pombe .

Eberhard J et al. MicroPubl Biol 2021 Apr 02;2021

PMID:18354085 - Diminishing HDACs by drugs or mutations promotes normal or abnormal sister chromatid separation by affecting APC/C and adherin.

Kimata Y et al. J Cell Sci 2008 Apr 01;121(Pt 7):1107-18

PMID:21760946 - Identification of genes affecting the toxicity of anti-cancer drug bortezomib by genome-wide screening in S. pombe.

Takeda K et al. PLoS One 2011;6(7):e22021

PMID:16822282 - Regulation of chronological aging in Schizosaccharomyces pombe by the protein kinases Pka1 and Sck2.

Roux AE et al. Aging Cell 2006 Aug;5(4):345-57

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:8536311 - Schizosaccharomyces pombe pac2+ controls the onset of sexual development via a pathway independent of the cAMP cascade.

Kunitomo H et al. Curr Genet 1995 Jun;28(1):32-8

PMID:30148840 - Tdp1 processes chromate-induced single-strand DNA breaks that collapse replication forks.

Ganguly A et al. PLoS Genet 2018 Aug;14(8):e1007595

PMID:21869531 - Complex formation, phosphorylation, and localization of protein kinase A of Schizosaccharomyces pombe upon glucose starvation.

Gupta DR et al. Biosci Biotechnol Biochem 2011;75(8):1456-65

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:38889144 - Cytoplasmic fluidization contributes to breaking spore dormancy in fission yeast.

Sakai K et al. Proc Natl Acad Sci U S A 2024 Jun 25;121(26):e2405553121

PMID:16688222 - Histone H2B mutations in inner region affect ubiquitination, centromere function, silencing and chromosome segregation.

Maruyama T et al. EMBO J 2006 Jun 07;25(11):2420-31

PMID:8144551 - Cloning of the pka1 gene encoding the catalytic subunit of the cAMP-dependent protein kinase in Schizosaccharomyces pombe.

Maeda T et al. J Biol Chem 1994 Apr 01;269(13):9632-7

PMID:8832414 - The Schizosaccharomyces pombe pyp1 protein tyrosine phosphatase negatively regulates nutrient monitoring pathways.

Santo PD et al. J Cell Sci 1996 Jul;109 ( Pt 7)(0 7):1919-1925

PMID:21169418 - Systematic screen of Schizosaccharomyces pombe deletion collection uncovers parallel evolution of the phosphate signal transduction pathway in yeasts.

Henry TC et al. Eukaryot Cell 2011 Feb;10(2):198-206

PMID:32142608 - Mutations in a Single Signaling Pathway Allow Cell Growth in Heavy Water.

Kampmeyer C et al. ACS Synth Biol 2020 Apr 17;9(4):733-748

PMID:8898110 - The activity of the gluconate-H+ symporter of Schizosaccharomyces pombe cells is down-regulated by D-glucose and exogenous cAMP.

Caspari T et al. FEBS Lett 1996 Oct 21;395(2-3):272-6

PMID:26443240 - PKA antagonizes CLASP-dependent microtubule stabilization to re-localize Pom1 and buffer cell size upon glucose limitation.

Kelkar M et al. Nat Commun 2015 Oct 07;6:8445

PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.

Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323

PMID:28388826 - Sulfur restriction extends fission yeast chronological lifespan through Ecl1 family genes by downregulation of ribosome.

Ohtsuka H et al. Mol Microbiol 2017 Jul;105(1):84-97

PMID:36358992 - Multi-Layered Regulations on the Chromatin Architectures: Establishing the Tight and Specific Responses of Fission Yeast fbp1 Gene Transcription.

Asada R et al. Biomolecules 2022 Nov 05;12(11)

PMID:29432178 - General amino acid control in fission yeast is regulated by a nonconserved transcription factor, with functions analogous to Gcn4/Atf4.

Duncan CDS et al. Proc Natl Acad Sci U S A 2018 Feb 20;115(8):E1829-E1838

PMID:11739717 - Protein kinase A regulates sexual development and gluconeogenesis through phosphorylation of the Zn finger transcriptional activator Rst2p in fission yeast.

Higuchi T et al. Mol Cell Biol 2002 Jan;22(1):1-11

PMID:22252817 - A genomewide screen in Schizosaccharomyces pombe for genes affecting the sensitivity of antifungal drugs that target ergosterol biosynthesis.

Fang Y et al. Antimicrob Agents Chemother 2012 Apr;56(4):1949-59

PMID:9202173 - Osmo-stress-induced changes in neutral trehalase activity of the fission yeast Schizosaccharomyces pombe.

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PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.

Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101

PMID:8001792 - Glucose repression of fbp1 transcription of Schizosaccharomyces pombe is partially regulated by adenylate cyclase activation by a G protein alpha subunit encoded by gpa2 (git8).

Nocero M et al. Genetics 1994 Sep;138(1):39-45

PMID:12715160 - The phospholipase B homolog Plb1 is a mediator of osmotic stress response and of nutrient-dependent repression of sexual differentiation in the fission yeast Schizosaccharomyces pombe.

Yang P et al. Mol Genet Genomics 2003 Apr;269(1):116-25

PMID:19672306 - Genome-wide screen of genes required for caffeine tolerance in fission yeast.

Calvo IA et al. PLoS One 2009 Aug 12;4(8):e6619

PMID:31030285 - CoQ 10 production in Schizosaccharomyces pombe is increased by reduction of glucose levels or deletion of pka1.

Nishida I et al. Appl Microbiol Biotechnol 2019 Jun;103(12):4899-4915

PMID:20537132 - Global fitness profiling of fission yeast deletion strains by barcode sequencing.

Han TX et al. Genome Biol 2010;11(6):R60

PMID:20634885 - TOR and PKA pathways synergize at the level of the Ste11 transcription factor to prevent mating and meiosis in fission yeast.

Valbuena N et al. PLoS One 2010 Jul 09;5(7):e11514

PMID:20501954 - Search for kinases related to transition of growth polarity in fission yeast.

Koyano T et al. Biosci Biotechnol Biochem 2010;74(5):1129-33

PMID:21098141 - Cellular stress induces cytoplasmic RNA granules in fission yeast.

Nilsson D et al. RNA 2011 Jan;17(1):120-33

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:37788281 - A dominant negative 14-3-3 mutant in Schizosaccharomyces pombe distinguishes the binding proteins involved in sexual differentiation and check point.

Ohshima T et al. PLoS One 2023;18(10):e0291524

PMID:9495778 - Characterization of mutants devoid of neutral trehalase activity in the fission yeast Schizosaccharomyces pombe: partial protection from heat shock and high-salt stress.

Cansado J et al. J Bacteriol 1998 Mar;180(5):1342-5

PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.

Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514

PMID:1657594 - Interaction between ran1+ protein kinase and cAMP dependent protein kinase as negative regulators of fission yeast meiosis.

DeVoti J et al. EMBO J 1991 Dec;10(12):3759-68

PMID:22624651 - A systematic screen reveals new elements acting at the G2/M cell cycle control.

Navarro FJ et al. Genome Biol 2012 May 24;13(5):R36

PMID:22496451 - Genetic screening for regulators of Prz1, a transcriptional factor acting downstream of calcineurin in fission yeast.

Koike A et al. J Biol Chem 2012 Jun 01;287(23):19294-303

PMID:36112198 - Synergistic roles of the phospholipase B homolog Plb1 and the cAMP-dependent protein kinase Pka1 in the hypertonic stress response of Schizosaccharomyces pombe.

Matsuo Y et al. Curr Genet 2022 Dec;68(5-6):661-674

PMID:31641022 - The cytosolic form of aspartate aminotransferase is required for full activation of TOR complex 1 in fission yeast.

Reidman S et al. J Biol Chem 2019 Nov 29;294(48):18244-18255

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:35820914 - Antagonistic effects of mitochondrial matrix and intermembrane space proteases on yeast aging.

Vega M et al. BMC Biol 2022 Jul 12;20(1):160

PMID:12664134 - Inactivation of Ran1/Pat1 kinase bypasses the requirement for high-level expression of mei2 during fission yeast meiosis.

Peng Z et al. Curr Genet 2003 Jun;43(3):178-85

PMID:30824696 - Systematic analysis reveals the prevalence and principles of bypassable gene essentiality.

Li J et al. Nat Commun 2019 Mar 01;10(1):1002

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:23551936 - TORC1 signaling inhibition by rapamycin and caffeine affect lifespan, global gene expression, and cell proliferation of fission yeast.

Rallis C et al. Aging Cell 2013 Aug;12(4):563-73

PMID:37052630 - Tfs1, transcription elongation factor TFIIS, has an impact on chromosome segregation affected by pka1 deletion in Schizosaccharomyces pombe.

Takenaka K et al. Curr Genet 2023 Jun;69(2-3):115-125

PMID:9245826 - Protein kinase Sck1 is involved in trehalase activation by glucose and nitrogen source in the fission yeast Schizosaccharomyces pombe.

Soto T et al. Microbiology (Reading) 1997 Jul;143 ( Pt 7):2457-2463

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:28281664 - Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes.

Rallis C et al. Sci Rep 2017 Mar 10;7:44257

PMID:15166138 - A novel gene, msa1, inhibits sexual differentiation in Schizosaccharomyces pombe.

Jeong HT et al. Genetics 2004 May;167(1):77-91

PMID:30301783 - The RHEB-mTOR axis regulates expression of Tf2 transposons in fission yeast.

Nakase Y et al. J Cell Sci 2018 Nov 21;131(22)

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405

PMID:9560431 - S. pombe sck2+, a second homologue of S. cerevisiae SCH9 in fission yeast, encodes a putative protein kinase closely related to PKA in function.

Fujita M et al. Curr Genet 1998 Apr;33(4):248-54

PMID:16143612 - Schizosaccharomyces pombe adenylate cyclase suppressor mutations suggest a role for cAMP phosphodiesterase regulation in feedback control of glucose/cAMP signaling.

Wang L et al. Genetics 2005 Dec;171(4):1523-33

PMID:11453251 - Factors involved in the regulation of the Schizosaccharomyces pombe malic enzyme gene.

Groenewald M et al. Curr Genet 2001 Jun;39(4):222-30

PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.

Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895

PMID:26366556 - Fission Yeast CSL Transcription Factors: Mapping Their Target Genes and Biological Roles.

Převorovský M et al. PLoS One 2015;10(9):e0137820

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

PMID:11004189 - Characterization of tpp1(+) as encoding a main trehalose-6P phosphatase in the fission yeast Schizosaccharomyces pombe.

Franco A et al. J Bacteriol 2000 Oct;182(20):5880-4

PMID:20655879 - The MAP kinase Pmk1 and protein kinase A are required for rotenone resistance in the fission yeast, Schizosaccharomyces pombe.

Wang Y et al. Biochem Biophys Res Commun 2010 Aug 20;399(2):123-8

PMID:31777167 - A new adaptation strategy to glucose starvation: modulation of the gluconate shunt and pentose phosphate pathway by the transcriptional repressor Rsv1.

Fraile R et al. FEBS J 2020 Mar;287(5):874-877

PMID:25373780 - A genomic Multiprocess survey of machineries that control and link cell shape, microtubule organization, and cell-cycle progression.

Graml V et al. Dev Cell 2014 Oct 27;31(2):227-239

PMID:9135083 - Schizosaccharomyces pombe gad7+ encodes a phosphoprotein with a bZIP domain, which is required for proper G1 arrest and gene expression under nitrogen starvation.

Kanoh J et al. Genes Cells 1996 Apr;1(4):391-408

PMID:12237855 - Genome-wide search of Schizosaccharomyces pombe genes causing overexpression-mediated cell cycle defects.

Tallada VA et al. Yeast 2002 Sep 30;19(13):1139-51

PMID:10388805 - Regulation of mRNA export by nutritional status in fission yeast.

Whalen WA et al. Genetics 1999 Jul;152(3):827-38

PMID:10747045 - The fission yeast git5 gene encodes a Gbeta subunit required for glucose-triggered adenylate cyclase activation.

Landry S et al. Genetics 2000 Apr;154(4):1463-71

PMID:25547512 - Dissection of the PHO pathway in Schizosaccharomyces pombe using epistasis and the alternate repressor adenine.

Estill M et al. Curr Genet 2015 May;61(2):175-83

PMID:25590601 - Fission yeast Ryh1 GTPase activates TOR Complex 2 in response to glucose.

Hatano T et al. Cell Cycle 2015;14(6):848-56

PMID:27756188 - cAMP-dependent protein kinase involves calcium tolerance through the regulation of Prz1 in Schizosaccharomyces pombe.

Matsuo Y et al. Biosci Biotechnol Biochem 2017 Feb;81(2):231-241

PMID:9671458 - An RNA binding protein negatively controlling differentiation in fission yeast.

Tsukahara K et al. Mol Cell Biol 1998 Aug;18(8):4488-98

PMID:9447985 - Novel factor highly conserved among eukaryotes controls sexual development in fission yeast.

Okazaki N et al. Mol Cell Biol 1998 Feb;18(2):887-95

PMID:11180454 - The cyclic AMP/PKA signal pathway is required for initiation of spore germination in Schizosaccharomyces pombe.

Hatanaka M et al. Yeast 2001 Feb;18(3):207-17

PMID:15189983 - Suppressors of an adenylate cyclase deletion in the fission yeast Schizosaccharomyces pombe.

Stiefel J et al. Eukaryot Cell 2004 Jun;3(3):610-9

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:18621924 - Regulation of the subcellular localization of cyclic AMP-dependent protein kinase in response to physiological stresses and sexual differentiation in the fission yeast Schizosaccharomyces pombe.

Matsuo Y et al. Eukaryot Cell 2008 Sep;7(9):1450-9

PMID:23074192 - Pmt1, a Dnmt2 homolog in Schizosaccharomyces pombe, mediates tRNA methylation in response to nutrient signaling.

Becker M et al. Nucleic Acids Res 2012 Dec;40(22):11648-58

PMID:34114004 - Identification of sur2 mutation affecting the lifespan of fission yeast.

Kurauchi T et al. FEMS Microbiol Lett 2021 Jun 24;368(12)

PMID:19264558 - Screening a genome-wide S. pombe deletion library identifies novel genes and pathways involved in genome stability maintenance.

Deshpande GP et al. DNA Repair (Amst) 2009 May 01;8(5):672-9

PMID:19542312 - Functional genomics of adhesion, invasion, and mycelial formation in Schizosaccharomyces pombe.

Dodgson J et al. Eukaryot Cell 2009 Aug;8(8):1298-306

PMID:12529438 - Global transcriptional responses of fission yeast to environmental stress.

Chen D et al. Mol Biol Cell 2003 Jan;14(1):214-29

PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.

Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160