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protein coding gene - ppr10 (SPBC106.19) - mitochondrial general translational activator, PPR repeat Ppr10

Gene summary

Standard name
ppr10
Systematic ID
SPBC106.19
Product
mitochondrial general translational activator, PPR repeat Ppr10
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
SPBC582.01, mpal10
UniProt ID
Q10340
ORFeome ID
44/44H12
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 414895..417163 forward strand

Annotation

GO biological process

GO:0070124 - mitochondrial translational initiation

References:

GO cellular component

GO:0005759 - mitochondrial matrix

References:

GO:0005739 - mitochondrion

References:

GO molecular function

GO:0005515 - protein binding

References:

GO:0030674 - protein-macromolecule adaptor activity

References:

GO:0008494 - translation activator activity

References:

Multi-locus phenotype

FYPO:0000245 - loss of viability in stationary phase

References:

Genotypes:

FYPO:0003095 - viable elongated vegetative cell, with progressive elongation

References:

Genotypes:

Protein features

PBO:0111828 - PPR repeats

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000078 - abnormal cellular respiration

References:

Genotypes:

FYPO:0008316 - abnormal mitochondrial translation initiation complex assembly

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Genotypes:

FYPO:0003730 - abolished cell population growth on galactose carbon source

References:

Genotypes:

FYPO:0001934 - abolished cell population growth on glycerol carbon source

References:

Genotypes:

FYPO:0000562 - abolished cellular respiration

References:

Genotypes:

FYPO:0000705 - abolished protein-protein interaction

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Genotypes:

FYPO:0004594 - branched, elongated, septated cell

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Genotypes:

FYPO:0000046 - decreased cell population growth

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Genotypes:

FYPO:0000080 - decreased cell population growth at low temperature

References:

Genotypes:

FYPO:0003743 - decreased cell population growth during glucose starvation

References:

Genotypes:

FYPO:0009078 - decreased cell population growth on ethanol carbon source

References:

Genotypes:

FYPO:0000251 - decreased cell population growth on galactose carbon source

References:

Genotypes:

FYPO:0009100 - decreased cell population growth on glycerol and galactose carbon source

References:

Genotypes:

FYPO:0000684 - decreased cell population growth on glycerol carbon source

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Genotypes:

FYPO:0009091 - decreased cell population growth on lysine and proline nitrogen source

References:

Genotypes:

FYPO:0002924 - decreased cell population growth on maltose carbon source

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Genotypes:

FYPO:0009099 - decreased cell population growth on mannitol carbon source

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Genotypes:

FYPO:0001176 - decreased cell population growth on sucrose carbon source

References:

Genotypes:

FYPO:0009097 - decreased cell population growth on xylose carbon source

References:

Genotypes:

FYPO:0005826 - decreased level of generation of precursor metabolites and energy gene mRNA during vegetative growth

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Genotypes:

FYPO:0003915 - decreased mitochondrial protein level

References:

Genotypes:

FYPO:0003423 - decreased mitochondrial RNA level

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Genotypes:

FYPO:0002056 - decreased mitochondrial translation

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Genotypes:

FYPO:0007525 - decreased ribosome binding

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Genotypes:

FYPO:0001117 - decreased RNA level during vegetative growth

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Genotypes:

FYPO:0003040 - decreased RNA splicing, via splicosome

References:

Genotypes:

FYPO:0001355 - decreased vegetative cell population growth

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Genotypes:

FYPO:0001919 - fragmented nucleus during vegetative growth

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Genotypes:

FYPO:0009072 - increased cell population growth on lysine nitrogen source

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Genotypes:

FYPO:0009028 - increased cell population growth on proline nitrogen source

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Genotypes:

FYPO:0005760 - increased cell-cell adhesion

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Genotypes:

FYPO:0002006 - increased cellular iron level

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Genotypes:

FYPO:0003004 - increased cellular reactive oxygen species level during vegetative growth

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Genotypes:

FYPO:0004153 - increased flocculation in stationary phase

References:

Genotypes:

FYPO:0000377 - increased frequency of apoptosis

References:

Genotypes:

FYPO:0003335 - increased galactose-specific flocculation

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Genotypes:

FYPO:0005505 - increased level of cell surface glycoprotein gene mRNA during vegetative growth

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Genotypes:

FYPO:0006597 - increased level of cell wall organization gene mRNA during vegetative growth

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Genotypes:

FYPO:0006596 - increased level of flocculin gene mRNA during vegetative growth

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Genotypes:

FYPO:0005420 - increased level of iron assimilation gene mRNA during vegetative growth

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Genotypes:

FYPO:0002664 - increased level of stress responsive gene mRNA during vegetative growth

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Genotypes:

FYPO:0005823 - increased phosphatidylserine externalization

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Genotypes:

FYPO:0005824 - increased plasma membrane permeability

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Genotypes:

FYPO:0003914 - increased protein level in stationary phase

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Genotypes:

FYPO:0008043 - increased protein localization to nucleus during stationary phase

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Genotypes:

FYPO:0001130 - increased protein localization to nucleus during vegetative growth

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Genotypes:

FYPO:0003776 - increased pseudohyphal growth

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Genotypes:

FYPO:0000825 - increased RNA level during vegetative growth

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Genotypes:

FYPO:0003991 - increased RNA level in stationary phase

References:

Genotypes:

FYPO:0000245 - loss of viability in stationary phase

References:

Genotypes:

FYPO:0002582 - normal mature mitochondrial tRNA level

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Genotypes:

FYPO:0005974 - normal mitochondrial protein level

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Genotypes:

FYPO:0008315 - normal mitochondrial ribosome assembly

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Genotypes:

FYPO:0000833 - normal protein level during vegetative growth

References:

Genotypes:

FYPO:0000703 - normal protein-protein interaction

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Genotypes:

FYPO:0000840 - normal RNA level

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Genotypes:

FYPO:0009068 - resistance to ciclopirox olamine

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Genotypes:

FYPO:0000764 - resistance to cycloheximide

References:

Genotypes:

FYPO:0001103 - resistance to hydrogen peroxide

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Genotypes:

FYPO:0001583 - resistance to lithium

References:

Genotypes:

FYPO:0009085 - resistance to lithium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0000077 - resistance to rapamycin

References:

Genotypes:

FYPO:0003383 - resistance to tert-butyl hydroperoxide

References:

Genotypes:

FYPO:0009067 - sensitive to amorolfine

References:

Genotypes:

FYPO:0000440 - sensitive to antimycin A

References:

Genotypes:

FYPO:0000097 - sensitive to caffeine during vegetative growth

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Genotypes:

FYPO:0000098 - sensitive to calcium

References:

Genotypes:

FYPO:0009080 - sensitive to calcofluor and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0000104 - sensitive to cycloheximide

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Genotypes:

FYPO:0007931 - sensitive to egtazic acid

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Genotypes:

FYPO:0000842 - sensitive to ethanol during vegetative growth

References:

Genotypes:

FYPO:0007928 - sensitive to ethylenediaminetetraacetic acid

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Genotypes:

FYPO:0000785 - sensitive to formamide

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Genotypes:

FYPO:0000088 - sensitive to hydroxyurea

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Genotypes:

FYPO:0005825 - sensitive to iron

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Genotypes:

FYPO:0006836 - sensitive to magnesium chloride

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Genotypes:

FYPO:0009088 - sensitive to magnesium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0000089 - sensitive to methyl methanesulfonate

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Genotypes:

FYPO:0001214 - sensitive to potassium chloride

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Genotypes:

FYPO:0007924 - sensitive to potassium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0001457 - sensitive to tunicamycin

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Genotypes:

FYPO:0000115 - sensitive to valproic acid

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Genotypes:

FYPO:0003656 - sensitive to vanadate

References:

Genotypes:

FYPO:0003810 - small fragmented mitochondria present in increased numbers

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Genotypes:

FYPO:0002380 - viable spheroid vegetative cell

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Genotypes:

FYPO:0002106 - viable stubby vegetative cell

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0016885 - Schizosaccharomyces specific

Orthologs

References / Literature

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:34119521 - Schizosaccharomyces pombe Ppr10 and Mpa1 together mediate mitochondrial translational initiation.
Luo Y et al. J Biol Chem 2021 Jul;297(1):100869
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:33049028 - Schizosaccharomyces pombe Ppr10 is required for mitochondrial translation.
Liu Z et al. FEMS Microbiol Lett 2020 Oct 21;367(19)
PMID:28334955 - The Schizosaccharomyces pombe PPR protein Ppr10 associates with a novel protein Mpa1 and acts as a mitochondrial translational activator.
Wang Y et al. Nucleic Acids Res 2017 Apr 07;45(6):3323-3340
PMID:38272226 - E3 ubiquitin ligase Hul6 modulates iron-dependent metabolism by regulating Php4 stability.
Yao R et al. J Biol Chem 2024 Jan 23;:105670
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:30321377 - Proteomic profiling and functional characterization of post-translational modifications of the fission yeast RNA exosome.
Telekawa C et al. Nucleic Acids Res 2018 Nov 30;46(21):11169-11183
PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.
Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:36174923 - Schizosaccharomyces pombe MAP kinase Sty1 promotes survival of Δppr10 cells with defective mitochondrial protein synthesis.
Hu Y et al. Int J Biochem Cell Biol 2022 Nov;152:106308
PMID:27918601 - Identifying genes required for respiratory growth of fission yeast.
Malecki M et al. Wellcome Open Res 2016;1:12
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;
PMID:27886462 - Loss of ppr3, ppr4, ppr6, or ppr10 perturbs iron homeostasis and leads to apoptotic cell death in Schizosaccharomyces pombe.
Su Y et al. FEBS J 2017 Jan;284(2):324-337
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:29878109 - Disruption of ppr3, ppr4, ppr6 or ppr10 induces flocculation and filamentous growth in Schizosaccharomyces pombe.
Su Y et al. FEMS Microbiol Lett 2018 Aug 01;365(16)