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protein coding gene - mrpl16 (SPBC1105.03c) - mitochondrial ribosomal protein subunit L16

Gene summary

Standard name
mrpl16
Systematic ID
SPBC1105.03c
Product
mitochondrial ribosomal protein subunit L16
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
mrpl1601
UniProt ID
Q9Y822
ORFeome ID
07/07D11
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome II: 3507523..3509133 reverse strand

Annotation

GO biological process

GO:0032543 - mitochondrial translation

References:

GO cellular component

GO:0005762 - mitochondrial large ribosomal subunit

References:

GO molecular function

GO:0019843 - rRNA binding

References:

GO:0003735 - structural constituent of ribosome

References:

Modification

MOD:01148 - ubiquitinylated lysine

References:

Protein sequence feature

SO:0001808 - mitochondrial_targeting_signal

References:

Qualitative gene expression

PomGeneEx:0000012 - RNA level decreased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0002111 - inviable tapered vegetative cell

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

FYPO:0002199 - inviable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF00252Ribosomal_L16Ribosomal_uL16Pfam
cd01433Ribosomal_L16_L10eRibosomal_uL16_domCDD
PS00701RIBOSOMAL_L16_2Ribosomal_uL16_CSPROSITE patterns
PR00060RIBOSOMALL16Ribosomal_uL16_bactPRINTS
G3DSA:3.90.1170.10Ribosomal_uL16_sfCATH-Gene3D
SSF54686Ribosomal_uL16_sfSUPERFAMILY
PTHR12220Ribosomal_uL16_bactPANTHER
TIGR01164rplP_bactRibosomal_uL16_bactNCBIFAM

Orthologs

References / Literature

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:34119521 - Schizosaccharomyces pombe Ppr10 and Mpa1 together mediate mitochondrial translational initiation.
Luo Y et al. J Biol Chem 2021 Jul;297(1):100869
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:38604460 - The Schizosaccharomyces pombe DEAD-box protein Mss116 is required for mitoribosome assembly and mitochondrial translation.
Wang Y et al. Mitochondrion 2024 Apr 09;76:101881
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:38499152 - Sls1 and Mtf2 mediate the assembly of the Mrh5C complex required for activation of cox1 mRNA translation.
Wang Y et al. J Biol Chem 2024 Mar 16;:107176
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:40427588 - The Insertion Domain of Mti2 Facilitates the Association of Mitochondrial Initiation Factors with Mitoribosomes in Schizosaccharomyces pombe .
Luo Y et al. Biomolecules 2025 May 10;15(5)
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36