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protein coding gene - pci2 (SPBC1105.07c) - TREX/TREX2 complex subunit Pci2

Gene summary

Standard name
pci2
Systematic ID
SPBC1105.07c
Product
TREX/TREX2 complex subunit Pci2
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
tho1
UniProt ID
Q9Y820
ORFeome ID
44/44H07
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome II: 3517625..3520103 reverse strand

Annotation

GO biological process

GO:0016973 - poly(A)+ mRNA export from nucleus

References:

GO:0000973 - post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery

References:

GO cellular component

GO:0005829 - cytosol

References:

GO:0005635 - nuclear envelope

References:

GO:0005634 - nucleus

References:

GO:0070390 - transcription export complex 2

References:

GO molecular function

GO:0003690 - double-stranded DNA binding

References:

GO:0003723 - RNA binding

References:

Qualitative gene expression

PomGeneEx:0000012 - RNA level decreased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0002451 - inviable vegetative cell with abnormal cell shape

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF01399PCIPCI_domPfam
PS50250PCIPCI_domPROSITE profiles
SM00753PAMSMART
G3DSA:1.10.10.10WH-like_DNA-bd_sfCATH-Gene3D
PTHR12732Csn12-likePANTHER

Orthologs

References / Literature

PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:36478272 - Translation-complex profiling of fission yeast cells reveals dynamic rearrangements of scanning ribosomal subunits upon nutritional stress.
Duncan CDS et al. Nucleic Acids Res 2022 Dec 09;50(22):13011-13025
PMID:19336419 - Cotranscriptional recruitment of the nuclear poly(A)-binding protein Pab2 to nascent transcripts and association with translating mRNPs.
Lemieux C et al. Nucleic Acids Res 2009 Jun;37(10):3418-30
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:41562396 - The THO complex in Schizosaccharomyces pombe-dissecting the composition and functional hierarchy.
He W et al. FEBS Lett 2026 Jan 21;
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:28821619 - Dsc E3 ligase localization to the Golgi requires the ATPase Cdc48 and cofactor Ufd1 for activation of sterol regulatory element-binding protein in fission yeast.
Burr R et al. J Biol Chem 2017 Sep 29;292(39):16333-16350
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:30355493 - Expanded Interactome of the Intrinsically Disordered Protein Dss1.
Schenstrøm SM et al. Cell Rep 2018 Oct 23;25(4):862-870