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protein coding gene - pth3 (SPBC1105.18c) - mitochondrial peptidyl-tRNA hydrolase, stalled-ribosome rescue factor srRF2, Pth3

Gene summary

Standard name
pth3
Systematic ID
SPBC1105.18c
Product
mitochondrial peptidyl-tRNA hydrolase, stalled-ribosome rescue factor srRF2, Pth3
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
SPBC887.21c
UniProt ID
Q9Y811
ORFeome ID
50/50B06
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 3538995..3539925 reverse strand

Annotation

Disease association

MONDO:0013306 - combined oxidative phosphorylation defect type 7

References:

MONDO:0014020 - hereditary spastic paraplegia 55

References:

GO biological process

GO:1990145 - maintenance of translational fidelity

References:

GO:0070126 - mitochondrial translational termination

References:

GO cellular component

GO:0005743 - mitochondrial inner membrane

References:

GO molecular function

GO:0004045 - peptidyl-tRNA hydrolase activity

References:

GO:0003747 - translation release factor activity

References:

Multi-locus phenotype

FYPO:0000442 - decreased cell population growth on glycerol/ethanol carbon source

References:

Genotypes:

Protein sequence feature

SO:0001808 - mitochondrial_targeting_signal

References:

Quantitative gene expression

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0003743 - decreased cell population growth during glucose starvation

References:

Genotypes:

FYPO:0009078 - decreased cell population growth on ethanol carbon source

References:

Genotypes:

FYPO:0009100 - decreased cell population growth on glycerol and galactose carbon source

References:

Genotypes:

FYPO:0000684 - decreased cell population growth on glycerol carbon source

References:

Genotypes:

FYPO:0000442 - decreased cell population growth on glycerol/ethanol carbon source

References:

Genotypes:

FYPO:0009091 - decreased cell population growth on lysine and proline nitrogen source

References:

Genotypes:

FYPO:0009092 - decreased cell population growth on lysine and serine nitrogen source

References:

Genotypes:

FYPO:0009073 - decreased cell population growth on lysine nitrogen source

References:

Genotypes:

FYPO:0009099 - decreased cell population growth on mannitol carbon source

References:

Genotypes:

FYPO:0007562 - decreased cell population growth on serine nitrogen source

References:

Genotypes:

FYPO:0003731 - normal growth on galactose carbon source

References:

Genotypes:

FYPO:0001164 - normal growth on glucose carbon source

References:

Genotypes:

FYPO:0009041 - resistance to 2,2′-dipyridyl

References:

Genotypes:

FYPO:0009031 - resistance to bleomycin

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Genotypes:

FYPO:0009038 - resistance to egtazic acid

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Genotypes:

FYPO:0001583 - resistance to lithium

References:

Genotypes:

FYPO:0009085 - resistance to lithium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0003383 - resistance to tert-butyl hydroperoxide

References:

Genotypes:

FYPO:0000104 - sensitive to cycloheximide

References:

Genotypes:

FYPO:0000089 - sensitive to methyl methanesulfonate

References:

Genotypes:

FYPO:0003656 - sensitive to vanadate

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF00472RF-1Pep_chain_release_fac_IPfam
G3DSA:3.30.160.20:FF:000065CATH-FunFam
G3DSA:3.30.160.20CATH-Gene3D
SSF75620Pep_chain_release_fac_I_sfSUPERFAMILY
PTHR46203Mito_Transl_Release_FactorPANTHER
mobidb-lite-Disorderdisorder_predictionMobiDB-Disorder
mobidb-lite-Positive-Polyelectrolytedisorder_predictionMobiDB-Positive-Polyelectrolyte

Orthologs

References / Literature

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:23892058 - Interactions between peptidyl tRNA hydrolase homologs and the ribosomal release factor Mrf1 in S. pombe mitochondria.
Dujeancourt L et al. Mitochondrion 2013 Nov;13(6):871-80
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
GO_REF:0000002 - Comments
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531