protein coding gene - mei3 (SPBC119.04) - meiosis inducing protein Mei3 OR meiosis inducing protein Mei3

Gene summary

Standard name

mei3

Systematic ID

SPBC119.04

Product

meiosis inducing protein Mei3 OR meiosis inducing protein Mei3

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

SPNCRNA.325

UniProt ID

P08090

ORFeome ID

42/42B03

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome II: 719585..720990 forward strand

Annotation

Protein features

References / Literature

PMID:29259000 - Genes Important for Schizosaccharomyces pombe Meiosis Identified Through a Functional Genomics Screen.

Blyth J et al. Genetics 2018 Feb;208(2):589-603

PMID:9799254 - Characterization of functional regions in the Schizosaccharomyces pombe mei3 developmental activator.

Wang W et al. Genetics 1998 Nov;150(3):1007-18

PMID:12664134 - Inactivation of Ran1/Pat1 kinase bypasses the requirement for high-level expression of mei2 during fission yeast meiosis.

Peng Z et al. Curr Genet 2003 Jun;43(3):178-85

PMID:11739793 - The Schizosaccharomyces pombe spo3+ gene is required for assembly of the forespore membrane and genetically interacts with psy1(+)-encoding syntaxin-like protein.

Nakamura T et al. Mol Biol Cell 2001 Dec;12(12):3955-72

PMID:41298081 - Gamete fusion triggers cytosolic functions and P-body recruitment of the RNA-binding protein Mei2 to drive fission yeast zygotic development.

Araoyinbo A et al. Genes Dev 2025 Nov 26;

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:2300054 - Schizosaccharomyces pombe ras1 and byr1 are functionally related genes of the ste family that affect starvation-induced transcription of mating-type genes.

Nadin-Davis SA et al. Mol Cell Biol 1990 Feb;10(2):549-60

PMID:3870979 - ran1+ controls the transition from mitotic division to meiosis in fission yeast.

Beach D et al. Curr Genet 1985;10(4):297-311

PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.

Mata J et al. Nat Genet 2002 Sep;32(1):143-7

PMID:24957674 - Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts.

Anver S et al. EMBO Rep 2014 Aug;15(8):894-902

PMID:17046992 - Fission yeast Tor2 promotes cell growth and represses cell differentiation.

Alvarez B et al. J Cell Sci 2006 Nov 01;119(Pt 21):4475-85

PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.

Skribbe M et al. Mol Cell 2025 Feb 19;

PMID:19714215 - The fission yeast homeodomain protein Yox1p binds to MBF and confines MBF-dependent cell-cycle transcription to G1-S via negative feedback.

Aligianni S et al. PLoS Genet 2009 Aug;5(8):e1000626

PMID:30089908 - Gamete fusion triggers bipartite transcription factor assembly to block re-fertilization.

Vještica A et al. Nature 2018 Aug;560(7718):397-400

PMID:23695164 - Cross-species protein interactome mapping reveals species-specific wiring of stress response pathways.

Das J et al. Sci Signal 2013 May 21;6(276):ra38

PMID:20118936 - Schizosaccharomyces pombe genome-wide nucleosome mapping reveals positioning mechanisms distinct from those of Saccharomyces cerevisiae.

Lantermann AB et al. Nat Struct Mol Biol 2010 Feb;17(2):251-7

PMID:4472733 - Premeiotic DNA synthesis in fission yeast.

Egel R et al. Exp Cell Res 1974 Sep;88(1):127-34

PMID:8945514 - Molecular mimicry in development: identification of ste11+ as a substrate and mei3+ as a pseudosubstrate inhibitor of ran1+ kinase.

Li P et al. Cell 1996 Nov 29;87(5):869-80

PMID:15713656 - Constitutive activation of the fission yeast pheromone-responsive pathway induces ectopic meiosis and reveals ste11 as a mitogen-activated protein kinase target.

Kjaerulff S et al. Mol Cell Biol 2005 Mar;25(5):2045-59

PMID:14648198 - DSC1-MCB regulation of meiotic transcription in Schizosaccharomyces pombe.

Cunliffe L et al. Mol Genet Genomics 2004 Feb;271(1):60-71

PMID:7651414 - Two-step activation of meiosis by the mat1 locus in Schizosaccharomyces pombe.

Willer M et al. Mol Cell Biol 1995 Sep;15(9):4964-70

PMID:9819418 - The mating-type proteins of fission yeast induce meiosis by directly activating mei3 transcription.

Van Heeckeren WJ et al. Mol Cell Biol 1998 Dec;18(12):7317-26

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:3357510 - A specific inhibitor of the ran1+ protein kinase regulates entry into meiosis in Schizosaccharomyces pombe.

McLeod M et al. Nature 1988 Apr 07;332(6164):509-14

PMID:14665462 - Sla1, a Schizosaccharomyces pombe homolog of the human La protein, induces ectopic meiosis when its C terminus is truncated.

Tanabe K et al. Eukaryot Cell 2003 Dec;2(6):1274-87

PMID:28281664 - Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes.

Rallis C et al. Sci Rep 2017 Mar 10;7:44257

PMID:2840284 - The S.pombe mei2 gene encoding a crucial molecule for commitment to meiosis is under the regulation of cAMP.

Watanabe Y et al. EMBO J 1988 Mar;7(3):761-7

PMID:3861929 - Characterization of meiosis-deficient mutants by electron microscopy and mapping of four essential genes in the fission yeast Schizosaccharomyces pombe.

Shimoda C et al. Mol Gen Genet 1985;200(2):252-7

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:3034608 - The product of the mei3+ gene, expressed under control of the mating-type locus, induces meiosis and sporulation in fission yeast.

McLeod M et al. EMBO J 1987 Mar;6(3):729-36

PMID:1657594 - Interaction between ran1+ protein kinase and cAMP dependent protein kinase as negative regulators of fission yeast meiosis.

DeVoti J et al. EMBO J 1991 Dec;10(12):3759-68

PMID:9062192 - Phosphorylation of RNA-binding protein controls cell cycle switch from mitotic to meiotic in fission yeast.

Watanabe Y et al. Nature 1997 Mar 13;386(6621):187-90

PMID:3025190 - Cloning and analysis of transcription of the mei2 gene responsible for initiation of meiosis in the fission yeast Schizosaccharomyces pombe.

Shimoda C et al. J Bacteriol 1987 Jan;169(1):93-6

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:24727291 - A genome-wide screen for sporulation-defective mutants in Schizosaccharomyces pombe.

Ucisik-Akkaya E et al. G3 (Bethesda) 2014 Apr 11;4(6):1173-82

PMID:28410370 - A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.

Dudin O et al. PLoS Genet 2017 Apr;13(4):e1006721

PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.

Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323