protein coding gene - pac1 (SPBC119.11c) - double-strand-specific ribonuclease Pac1

Gene summary

Standard name

pac1

Systematic ID

SPBC119.11c

Product

double-strand-specific ribonuclease Pac1

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

hcs, rnt1, snm1

UniProt ID

P22192

ORFeome ID

32/32E01

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome II: 737503..738826 reverse strand

Annotation

Protein features

Orthologs

• DROSHA (HGNC:17904) Homo sapiens
• pac1 (SJAG_04527) Schizosaccharomyces japonicus
• RNT1 (YMR239C) Saccharomyces cerevisiae

References / Literature

GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.

PMID:7616961 - Rescue of the fission yeast snRNA synthesis mutant snm1 by overexpression of the double-strand-specific Pac1 ribonuclease.

Rotondo G et al. Mol Gen Genet 1995 Jun 25;247(6):698-708

PMID:22496451 - Genetic screening for regulators of Prz1, a transcriptional factor acting downstream of calcineurin in fission yeast.

Koike A et al. J Biol Chem 2012 Jun 01;287(23):19294-303

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.

Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101

PMID:20609363 - Pac1 endonuclease and Dhp1p 5'-->3' exonuclease are required for U3 snoRNA termination in Schizosaccharomyces pombe.

Nabavi S et al. FEBS Lett 2010 Aug 04;584(15):3436-41

PMID:2205842 - A gene from S. pombe with homology to E. coli RNAse III blocks conjugation and sporulation when overexpressed in wild type cells.

Xu HP et al. Nucleic Acids Res 1990 Sep 11;18(17):5304

PMID:2406130 - A mutation in a single gene of Schizosaccharomyces pombe affects the expression of several snRNAs and causes defects in RNA processing.

Potashkin J et al. EMBO J 1990 Feb;9(2):525-34

PMID:18254616 - MMM-QSAR recognition of ribonucleases without alignment: comparison with an HMM model and isolation from Schizosaccharomyces pombe, prediction, and experimental assay of a new sequence.

Agüero-Chapín G et al. J Chem Inf Model 2008 Feb;48(2):434-48

PMID:9326493 - Substrate structure requirements of the Pac1 ribonuclease from Schizosaccharmyces pombe.

Rotondo G et al. RNA 1997 Oct;3(10):1182-93

PMID:31474649 - Identification of 15 New Bypassable Essential Genes of Fission Yeast.

Takeda A et al. Cell Struct Funct 2019 Sep 27;44(2):113-119

PMID:42420319 - Spliceosomal proteins direct RNA methylation to modulate gene expression and silence retrotransposons.

Vijayakumari D et al. Nat Commun 2026 Jul 08;

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:1989884 - S. pombe pac1+, whose overexpression inhibits sexual development, encodes a ribonuclease III-like RNase.

Iino Y et al. EMBO J 1991 Jan;10(1):221-6

PMID:10445882 - Pac1p, an RNase III homolog, is required for formation of the 3' end of U2 snRNA in Schizosaccharomyces pombe.

Zhou D et al. RNA 1999 Aug;5(8):1083-98

PMID:2840284 - The S.pombe mei2 gene encoding a crucial molecule for commitment to meiosis is under the regulation of cAMP.

Watanabe Y et al. EMBO J 1988 Mar;7(3):761-7

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405

PMID:20152800 - Cleavage-induced termination in U2 snRNA gene expression.

Nabavi S et al. Biochem Biophys Res Commun 2010 Mar 12;393(3):461-5

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:34352089 - Co-transcriptional RNA cleavage by Drosha homolog Pac1 triggers transcription termination in fission yeast.

Yague-Sanz C et al. Nucleic Acids Res 2021 Sep 07;49(15):8610-8624

PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.

Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:40859013 - RNase III cleavage sites spread across splice junctions enforce sequential snoRNA processing.

Migeot V et al. EMBO Rep 2025 Aug 26;

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:8534915 - Schizosaccharomyces pombe zfs1+ encoding a zinc-finger protein functions in the mating pheromone recognition pathway.

Kanoh J et al. Mol Biol Cell 1995 Sep;6(9):1185-95

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87

PMID:8144551 - Cloning of the pka1 gene encoding the catalytic subunit of the cAMP-dependent protein kinase in Schizosaccharomyces pombe.

Maeda T et al. J Biol Chem 1994 Apr 01;269(13):9632-7

PMID:8710510 - Purification and characterization of the Pac1 ribonuclease of Schizosaccharomyces pombe.

Rotondo G et al. Nucleic Acids Res 1996 Jun 15;24(12):2377-86

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6