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protein coding gene - rti1 (SPBC119.14) - Rad22 homolog Rti1

Gene summary

Standard name
rti1
Systematic ID
SPBC119.14
Product
Rad22 homolog Rti1
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
rad22B
UniProt ID
O42905
ORFeome ID
24/24F11
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 746035..747734 forward strand

Annotation

GO biological process

GO:0000730 - DNA recombinase assembly

References:

GO:0000724 - double-strand break repair via homologous recombination

References:

GO:0045002 - double-strand break repair via single-strand annealing

References:

GO:0006312 - mitotic recombination

References:

GO:0000723 - telomere maintenance

References:

GO cellular component

GO:0000228 - nuclear chromosome

References:

GO:0005634 - nucleus

References:

GO:0035861 - site of double-strand break

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GO molecular function

GO:0000150 - DNA strand exchange activity

References:

GO:0005515 - protein binding

References:

GO:0030674 - protein-macromolecule adaptor activity

References:

GO:0003697 - single-stranded DNA binding

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:00047 - O-phospho-L-threonine

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Multi-locus phenotype

FYPO:0005141 - decreased meiotic recombination double-strand break repair

References:

Genotypes:

FYPO:0005136 - normal meiotic DNA double-strand break formation

References:

Genotypes:

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

References:

Quantitative gene expression

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000251 - decreased cell population growth on galactose carbon source

References:

Genotypes:

FYPO:0000684 - decreased cell population growth on glycerol carbon source

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Genotypes:

FYPO:0003179 - decreased intragenic meiotic recombination

References:

Genotypes:

FYPO:0000636 - increased cell population growth rate

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Genotypes:

FYPO:0000473 - increased mitotic recombination

References:

Genotypes:

FYPO:0007425 - normal gene conversion

References:

Genotypes:

FYPO:0006811 - normal gross chromosomal rearrangement frequency

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Genotypes:

FYPO:0002169 - normal growth during cellular response to gamma radiation

References:

Genotypes:

FYPO:0000969 - normal growth during cellular response to UV

References:

Genotypes:

FYPO:0001690 - normal growth on camptothecin

References:

Genotypes:

FYPO:0000763 - resistance to cadmium

References:

Genotypes:

FYPO:0009038 - resistance to egtazic acid

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Genotypes:

FYPO:0001453 - resistance to ethanol

References:

Genotypes:

FYPO:0001583 - resistance to lithium

References:

Genotypes:

FYPO:0009085 - resistance to lithium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0003383 - resistance to tert-butyl hydroperoxide

References:

Genotypes:

FYPO:0000830 - resistance to vanadate

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Genotypes:

FYPO:0003612 - viable spore population

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Subunit composition

PBO:0015212 - homomeric(2)

References:

PBO:0015220 - homooligomeric

References:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF04098Rad52_Rad22Rad52_famPFAM
G3DSA:3.30.390.80:FF:000001FUNFAM
SSF54768dsRNA-binding domain-likeSUPERFAMILY
G3DSA:3.30.390.80DNA repair protein Rad52/59/22Rad52_Rad59_Rad22_sfGENE3D
PTHR12132DNA REPAIR AND RECOMBINATION PROTEIN RAD52, RAD59Rad52_Rad59_Rad22PANTHER
mobidb-lite-Disorderdisorder_predictionMOBIDB-Disorder
mobidb-lite-Polardisorder_predictionMOBIDB-Polar
TIGR00607rad52DNA_recomb/repair_Rad52NCBIFAM

Orthologs

References / Literature

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:23779158 - The proteasome factor Bag101 binds to Rad22 and suppresses homologous recombination.
Saito Y et al. Sci Rep 2013;3:2022
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.
Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:14551247 - Schizosaccharomyces pombe Rdh54 (TID1) acts with Rhp54 (RAD54) to repair meiotic double-strand breaks.
Catlett MG et al. Mol Biol Cell 2003 Nov;14(11):4707-20
PMID:11104907 - Characterization of RAD52 homologs in the fission yeast Schizosaccharomyces pombe.
van den Bosch M et al. Mutat Res 2001 Jan 05;461(4):311-23
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:25452419 - Parallel profiling of fission yeast deletion mutants for proliferation and for lifespan during long-term quiescence.
Sideri T et al. G3 (Bethesda) 2014 Dec 01;5(1):145-55
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:10512870 - A double-strand break repair component is essential for S phase completion in fission yeast cell cycling.
Suto K et al. Mol Biol Cell 1999 Oct;10(10):3331-43
PMID:11884628 - Differential expression and requirements for Schizosaccharomyces pombe RAD52 homologs in DNA repair and recombination.
van den Bosch M et al. Nucleic Acids Res 2002 Mar 15;30(6):1316-24
PMID:18818364 - Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast.
Roguev A et al. Science 2008 Oct 17;322(5900):405-10
PMID:21149262 - A failure of meiotic chromosome segregation in a fbh1Delta mutant correlates with persistent Rad51-DNA associations.
Sun W et al. Nucleic Acids Res 2011 Mar;39(5):1718-31
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:26670050 - Regulation of mRNA Levels by Decay-Promoting Introns that Recruit the Exosome Specificity Factor Mmi1.
Kilchert C et al. Cell Rep 2015 Dec 22;13(11):2504-2515
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:11560889 - Multiple interactions among the components of the recombinational DNA repair system in Schizosaccharomyces pombe.
Tsutsui Y et al. Genetics 2001 Sep;159(1):91-105
PMID:17208257 - Schizosaccharomyces pombe Rad22A and Rad22B have similar biochemical properties and form multimeric structures.
de Vries FA et al. Mutat Res 2007 Feb 03;615(1-2):143-52
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:32355220 - DNA replication machinery prevents Rad52-dependent single-strand annealing that leads to gross chromosomal rearrangements at centromeres.
Onaka AT et al. Commun Biol 2020 Apr 30;3(1):202
PMID:15238514 - Conserved and nonconserved proteins for meiotic DNA breakage and repair in yeasts.
Young JA et al. Genetics 2004 Jun;167(2):593-605
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623