protein coding gene - cym1 (SPBC119.17) - mitochondrial processing endopeptidase Cym1

Gene summary

Standard name: cym1
Systematic ID: SPBC119.17
Product: mitochondrial processing endopeptidase Cym1
Organism: Schizosaccharomyces pombe (fission yeast)
Synonyms: SPBC577.01, ppp37
UniProt ID: O42908
ORFeome ID: 47/47G06
Characterisation status: biological role inferred
Feature type: mRNA gene
Genomic location: chromosome II: 750756..754123 forward strand

Annotation

Disease association

MONDO:0030318 - spinocerebellar ataxia, autosomal recessive 30

References:

PB_REF:0000006

GO biological process

GO:0016485 - protein processing

References:

GO_REF:0000024

GO cellular component

GO:0005758 - mitochondrial intermembrane space

References:

GO_REF:0000044

GO:0005759 - mitochondrial matrix

References:

GO_REF:0000033

GO:0005739 - mitochondrion

References:

PMID:16823372

GO molecular function

GO:0008237 - metallopeptidase activity

References:

GO_REF:0000024

GO:0008270 - zinc ion binding

References:

GO_REF:0000024

Modification

MOD:00046 - O-phospho-L-serine

References:

PMID:30726745

MOD:01148 - ubiquitinylated lysine

References:

PMID:37970674

Protein sequence feature

SO:0001808 - mitochondrial_targeting_signal

References:

PMID:36408920

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

References:

PMID:39367033

PomGeneEx:0000012 - RNA level decreased

References:

PMID:27984744

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

PMID:23101633

Single locus phenotype

FYPO:0002111 - inviable tapered vegetative cell

References:

PMID:23697806

Genotypes:

cym1delta

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

cym1delta

FYPO:0006680 - sensitive to bisphenol A

References:

PMID:30099677

Genotypes:

cym1delta

FYPO:0001234 - slow vegetative cell population growth

References:

PMID:16491466

Genotypes:

cym1delta

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

ID	Name	InterPro name	DB name
PF05193	Peptidase_M16_C	Peptidase_M16_C	PFAM
PF00675	Peptidase_M16	Pept_M16_N	PFAM
PF08367	M16C_assoc	Peptidase_M16C_assoc	PFAM
PF22516	PreP_C	PreP_C	PFAM
SM01264	M16C_assoc_2	Peptidase_M16C_assoc	SMART
G3DSA:3.30.830.10:FF:000011			FUNFAM
G3DSA:3.30.830.10:FF:000013			FUNFAM
G3DSA:3.30.830.10:FF:000009			FUNFAM
SSF63411	LuxS/MPP-like metallohydrolase	Metalloenz_LuxS/M16	SUPERFAMILY
G3DSA:3.30.830.10			GENE3D
PTHR43016	PRESEQUENCE PROTEASE		PANTHER
Coil	Coil		COILS

Orthologs

PITRM1 (HGNC:17663) Homo sapiens
cym1 (SJAG_04533) Schizosaccharomyces japonicus
CYM1 (YDR430C) Saccharomyces cerevisiae

References / Literature

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.: Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.: Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.: Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:16491466 - Construction of a protease-deficient strain set for the fission yeast Schizosaccharomyces pombe, useful for effective production of protease-sensitive heterologous proteins.: Idiris A et al. Yeast 2006 Jan 30;23(2):83-99
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:21511999 - Comparative functional genomics of the fission yeasts.: Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:30099677 - Genome-wide evidences of bisphenol a toxicity using Schizosaccharomyces pombe.: Kim DM et al. Arch Pharm Res 2018 Aug;41(8):830-837
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.: Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
GO_REF:0000044 - Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt.
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.: Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:23163955 - Analysis of stress-induced duplex destabilization (SIDD) properties of replication origins, genes and intergenes in the fission yeast, Schizosaccharomyces pombe.: Yadav MP et al. BMC Res Notes 2012 Nov 19;5:643
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.: Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.: UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.: Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).: Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36