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protein coding gene - cym1 (SPBC119.17) - mitochondrial matrix presequence degrading endopeptidase Cym1

Gene summary

Standard name
cym1
Systematic ID
SPBC119.17
Product
mitochondrial matrix presequence degrading endopeptidase Cym1
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
SPBC577.01, ppp37
UniProt ID
O42908
ORFeome ID
47/47G06
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome II: 750756..754123 forward strand

Annotation

Disease association

MONDO:0030318 - spinocerebellar ataxia, autosomal recessive 30

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GO biological process

GO:0043171 - peptide catabolic process

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GO cellular component

GO:0005758 - mitochondrial intermembrane space

References:

GO:0005759 - mitochondrial matrix

References:

GO:0005739 - mitochondrion

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GO molecular function

GO:0004222 - metalloendopeptidase activity

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GO:0008270 - zinc ion binding

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Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:01148 - ubiquitinylated lysine

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Protein sequence feature

SO:0001808 - mitochondrial_targeting_signal

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Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

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PomGeneEx:0000012 - RNA level decreased

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PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0002111 - inviable tapered vegetative cell

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

FYPO:0006680 - sensitive to bisphenol A

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Genotypes:

FYPO:0001234 - slow vegetative cell population growth

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF00675Peptidase_M16Pept_M16_NPfam
PF05193Peptidase_M16_CPeptidase_M16_CPfam
PF08367M16C_assocPeptidase_M16C_assocPfam
PF22516PreP_CPreP_CPfam
SM01264M16C_associatedPeptidase_M16C_assocSMART
G3DSA:3.30.830.10:FF:000009CATH-FunFam
G3DSA:3.30.830.10:FF:000011CATH-FunFam
G3DSA:3.30.830.10:FF:000013CATH-FunFam
G3DSA:3.30.830.10CATH-Gene3D
SSF63411Metalloenz_LuxS/M16SUPERFAMILY
PTHR43016PANTHER
CoilCOILS

Orthologs

References / Literature

PMID:30099677 - Genome-wide evidences of bisphenol a toxicity using Schizosaccharomyces pombe.
Kim DM et al. Arch Pharm Res 2018 Aug;41(8):830-837
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:23163955 - Analysis of stress-induced duplex destabilization (SIDD) properties of replication origins, genes and intergenes in the fission yeast, Schizosaccharomyces pombe.
Yadav MP et al. BMC Res Notes 2012 Nov 19;5:643
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.
Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
PMID:16491466 - Construction of a protease-deficient strain set for the fission yeast Schizosaccharomyces pombe, useful for effective production of protease-sensitive heterologous proteins.
Idiris A et al. Yeast 2006 Jan 30;23(2):83-99
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.
Mata J et al. Nat Genet 2002 Sep;32(1):143-7
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6