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protein coding gene - fmd2 (SPBC1198.01) - glutathione-dependent formaldehyde dehydrogenase Fmd2

Gene summary

Standard name
fmd2
Systematic ID
SPBC1198.01
Product
glutathione-dependent formaldehyde dehydrogenase Fmd2
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q9P6I8
ORFeome ID
20/20D04
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 172627..174315 forward strand

Annotation

GO biological process

GO:0070458 - cellular detoxification of nitrogen compound

References:

GO:0071500 - cellular response to nitrosative stress

References:

GO cellular component

GO:0005794 - Golgi apparatus

References:

GO molecular function

GO:0016491 - oxidoreductase activity

References:

GO:0008270 - zinc ion binding

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Multi-locus phenotype

FYPO:0006409 - increased cellular nitric oxide level during stationary phase

References:

Genotypes:

FYPO:0003114 - increased cellular nitric oxide level during vegetative growth

References:

Genotypes:

FYPO:0007615 - increased transcription from STREP promoter during cellular response to nitric oxide

References:

Genotypes:

FYPO:0006407 - sensitive to nitrosative stress

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Genotypes:

Qualitative gene expression

PomGeneEx:0000022 - protein absent

References:

PomGeneEx:0000018 - protein level increased

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PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0007615 - increased transcription from STREP promoter during cellular response to nitric oxide

References:

Genotypes:

FYPO:0005776 - normal growth on acetaldehyde

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Genotypes:

FYPO:0007331 - normal growth on formaldehyde

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Genotypes:

FYPO:0009079 - resistance to calcofluor and sodium dodecyl sulfate

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Genotypes:

FYPO:0002693 - resistance to diamide

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Genotypes:

FYPO:0001103 - resistance to hydrogen peroxide

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Genotypes:

FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0007808 - resistance to valproic acid

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Genotypes:

FYPO:0007933 - sensitive to 2,2′-dipyridyl

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Genotypes:

FYPO:0007931 - sensitive to egtazic acid

References:

Genotypes:

FYPO:0000089 - sensitive to methyl methanesulfonate

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Genotypes:

FYPO:0002328 - sensitive to terbinafine

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Genotypes:

FYPO:0000797 - sensitive to tert-butyl hydroperoxide

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Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

Protein features

IDNameInterPro nameDB name
PF08240ADH_NADH-like_NPFAM
PF00107ADH_zinc_NADH-like_CPFAM
cd08283FDH_like_1CDD
PS00059ADH_ZINCADH_Zn_CSPROSITE_PATTERNS
SSF50129GroES-likeGroES-like_sfSUPERFAMILY
SSF51735NAD(P)-binding Rossmann-fold domainsNAD(P)-bd_dom_sfSUPERFAMILY
G3DSA:3.40.50.720GENE3D
G3DSA:3.90.180.10GENE3D
PTHR42813ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKEPANTHER
mobidb-lite-Disorderdisorder_predictionMOBIDB-Disorder

Orthologs

References / Literature

PMID:21828039 - Mfc1 is a novel forespore membrane copper transporter in meiotic and sporulating cells.
Beaudoin J et al. J Biol Chem 2011 Sep 30;286(39):34356-72
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.
Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
PMID:30355493 - Expanded Interactome of the Intrinsically Disordered Protein Dss1.
Schenstrøm SM et al. Cell Rep 2018 Oct 23;25(4):862-870
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.
Mata J et al. Nat Genet 2002 Sep;32(1):143-7
PMID:33400299 - Role of mitochondrial complex III/IV in the activation of transcription factor Rst2 in Schizosaccharomyces pombe.
Jiang G et al. Mol Microbiol 2021 Jun;115(6):1323-1338
GO_REF:0000002 - Comments
PMID:32034465 - Genetic investigation of formaldehyde-induced DNA damage response in Schizosaccharomyces pombe.
Anandarajan V et al. Curr Genet 2020 Jun;66(3):593-605
PMID:31626996 - Multiplexed proteome profiling of carbon source perturbations in two yeast species with SL-SP3-TMT.
Paulo JA et al. J Proteomics 2020 Jan 06;210:103531
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;
PMID:26645666 - Nitric oxide signaling and its role in oxidative stress response in Schizosaccharomyces pombe.
Astuti RI et al. Nitric Oxide 2016 Jan 30;52:29-40
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:22840777 - Analyzing fission yeast multidrug resistance mechanisms to develop a genetically tractable model system for chemical biology.
Kawashima SA et al. Chem Biol 2012 Jul 27;19(7):893-901
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623