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protein coding gene - dea2 (SPBC1198.02) - adenine deaminase Dea2

Gene summary

Standard name
dea2
Systematic ID
SPBC1198.02
Product
adenine deaminase Dea2
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q9P6I7
ORFeome ID
17/17D01
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 174816..176135 forward strand

Annotation

PBO:0003042 - 3.5.4.2

Catalytic activity attributes

PBO:0091662 - kcat/KM 0.46

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Disease association

MONDO:0019254 - inborn disorder of purine or pyrimidine metabolism

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MONDO:0003778 - inborn error of immunity

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MONDO:0005066 - metabolic disease

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MONDO:0015974 - severe combined immunodeficiency

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MONDO:0007064 - severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-negative, due to adenosine deaminase deficiency

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GO biological process

GO:0006146 - adenine catabolic process

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GO:0043103 - hypoxanthine salvage

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GO cellular component

GO:0005829 - cytosol

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GO:0005634 - nucleus

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GO molecular function

GO:0000034 - adenine deaminase activity

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GO:0008270 - zinc ion binding

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Modification

MOD:01148 - ubiquitinylated lysine

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Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

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PomGeneEx:0000012 - RNA level decreased

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Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000059 - abnormal mitotic cell cycle

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Genotypes:

FYPO:0001324 - decreased protein level during vegetative growth

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Genotypes:

FYPO:0002280 - inviable after spore germination, single cell division

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Genotypes:

FYPO:0002379 - inviable after spore germination, without cell division, with elongated germ tube

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Genotypes:

FYPO:0000310 - inviable after spore germination, without cell division, with normal germ tube morphology

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

FYPO:0001492 - viable elongated vegetative cell

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Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF00962A_deaminaseA_deaminase_domPFAM
cd01320ADAAdo/ade_deaminaseCDD
G3DSA:3.20.20.140:FF:000039FUNFAM
SSF51556Metallo-dependent hydrolasesMetal_HydrolaseSUPERFAMILY
G3DSA:3.20.20.140GENE3D
PTHR43114ADENINE DEAMINASEAdo/ade_deaminasePANTHER
MF_01962Adenine_deaminaseADEHAMAP
TIGR01430aden_deamAdo/ade_deaminaseNCBIFAM

Orthologs

References / Literature

PMID:22540037 - Predicting the fission yeast protein interaction network.
Pancaldi V et al. G3 (Bethesda) 2012 Apr;2(4):453-67
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.
Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
PMID:27736299 - A genome-wide screen to identify genes controlling the rate of entry into mitosis in fission yeast.
Moris N et al. Cell Cycle 2016 Nov 16;15(22):3121-3130
PMID:14643670 - Sub-families of alpha/beta barrel enzymes: a new adenine deaminase family.
Ribard C et al. J Mol Biol 2003 Dec 12;334(5):1117-31
PMID:18673302 - Hydrolytic cleavage of N6-substituted adenine derivatives by eukaryotic adenine and adenosine deaminases.
Pospísilová H et al. Biosci Rep 2008 Dec;28(6):335-47
PMID:12529438 - Global transcriptional responses of fission yeast to environmental stress.
Chen D et al. Mol Biol Cell 2003 Jan;14(1):214-29
PMID:12738880 - TRAP230/ARC240 and TRAP240/ARC250 Mediator subunits are functionally conserved through evolution.
Samuelsen CO et al. Proc Natl Acad Sci U S A 2003 May 27;100(11):6422-7
PMID:19933844 - Fission yeast Iec1-ino80-mediated nucleosome eviction regulates nucleotide and phosphate metabolism.
Hogan CJ et al. Mol Cell Biol 2010 Feb;30(3):657-74
PMID:5139537 - Study of adenine aminohydrolase in the yeast, Schizosaccharomyces pombe.
Abbondandolo A et al. J Bacteriol 1971 Dec;108(3):959-63
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PB_REF:0000003 - Disease Association Curation
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:31626996 - Multiplexed proteome profiling of carbon source perturbations in two yeast species with SL-SP3-TMT.
Paulo JA et al. J Proteomics 2020 Jan 06;210:103531
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
GO_REF:0000104 - Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features.