protein coding gene - guk1 (SPBC1198.05) - guanylate kinase Guk1

Gene summary

Standard name: guk1
Systematic ID: SPBC1198.05
Product: guanylate kinase Guk1
Organism: Schizosaccharomyces pombe (fission yeast)
UniProt ID: Q9P6I5
ORFeome ID: 06/06G11
Characterisation status: biological role inferred
Feature type: mRNA gene
Genomic location: chromosome II: 181582..182528 forward strand

Annotation

PBO:0003062 - 2.7.4.8

Disease association

MONDO:0976132 - mitochondrial dna depletion syndrome 21

References:

PB_REF:0000006

GO biological process

GO:0046037 - GMP metabolic process

References:

GO_REF:0000111

GO:0006183 - GTP biosynthetic process

References:

GO_REF:0000111

GO cellular component

GO:0005829 - cytosol

References:

GO_REF:0000033

GO:0005634 - nucleus

References:

GO_REF:0000024

GO molecular function

GO:0004385 - GMP kinase activity

References:

GO_REF:0000033

Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:00047 - O-phospho-L-threonine

References:

MOD:00696 - phosphorylated residue

References:

PMID:19547744

MOD:01148 - ubiquitinylated lysine

References:

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

References:

PomGeneEx:0000027 - ribosomal density decreased

References:

PomGeneEx:0000012 - RNA level decreased

References:

PMID:27984744

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

PMID:23101633

Single locus phenotype

FYPO:0000310 - inviable after spore germination, without cell division, with normal germ tube morphology

References:

PMID:23697806

Genotypes:

guk1delta

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

guk1delta

FYPO:0000021 - spheroid vegetative cell

References:

PMID:23697806

Genotypes:

guk1delta

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

ID	Name	InterPro name	DB name
PF00625	Guanylate_kin	GK/Ca_channel_bsu	PFAM
cd00071	GMPK		CDD
PS00856	GUANYLATE_KINASE_1	Guanylate_kinase_CS	PROSITE_PATTERNS
PS50052	GUANYLATE_KINASE_2	Guanylate_kin-like_dom	PROSITE_PROFILES
SM00072	gk_7	GK/Ca_channel_bsu	SMART
G3DSA:3.40.50.300:FF:000776			FUNFAM
G3DSA:3.30.63.10:FF:000002			FUNFAM
SSF52540	P-loop containing nucleoside triphosphate hydrolases	P-loop_NTPase	SUPERFAMILY
G3DSA:3.40.50.300		P-loop_NTPase	GENE3D
PTHR23117	GUANYLATE KINASE-RELATED		PANTHER
TIGR03263	guanyl_kin	Guanylate_kinase	NCBIFAM

Orthologs

GUK1 (HGNC:4693) Homo sapiens
guk1 (SJAG_04849) Schizosaccharomyces japonicus
GUK1 (YDR454C) Saccharomyces cerevisiae

References / Literature

GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.: Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.: Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.: Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:21511999 - Comparative functional genomics of the fission yeasts.: Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.: Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.: Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.: Halova L et al. Open Biol 2021 Apr;11(4):200405
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:36478272 - Translation-complex profiling of fission yeast cells reveals dynamic rearrangements of scanning ribosomal subunits upon nutritional stress.: Duncan CDS et al. Nucleic Acids Res 2022 Dec 09;50(22):13011-13025
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).: Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.: Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:41259369 - Hydroxyurea induces an oxidative stress response that triggers ER expansion and cytoplasmic protein aggregation.: Sánchez-Molina A et al. PLoS Biol 2025 Nov 19;23(11):e3003493
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.: Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:19547744 - Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.: Beltrao P et al. PLoS Biol 2009 Jun 16;7(6):e1000134
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.: Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.: Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.: Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.: Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.: Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7