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protein coding gene - slm5 (SPBC1198.10c) - mitochondrial asparagine-tRNA ligase Slm5

Gene summary

Standard name
slm5
Systematic ID
SPBC1198.10c
Product
mitochondrial asparagine-tRNA ligase Slm5
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q9P6I0
ORFeome ID
23/23F09
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome II: 188789..191676 reverse strand

Annotation

PBO:0003066 - 6.1.1.22

Disease association

MONDO:0014547 - combined oxidative phosphorylation defect type 24

References:

MONDO:0032749 - hearing loss, autosomal recessive 94

References:

GO biological process

GO:0006421 - asparaginyl-tRNA aminoacylation

References:

GO cellular component

GO:0005759 - mitochondrial matrix

References:

GO:0005739 - mitochondrion

References:

GO molecular function

GO:0004816 - asparagine-tRNA ligase activity

References:

GO:0005524 - ATP binding

References:

GO:0000049 - tRNA binding

References:

Protein features

PBO:0111871 - OB fold

Quantitative gene expression

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0002111 - inviable tapered vegetative cell

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF00152tRNA-synt_2Aa-tRNA-synt_IIPfam
PF01336tRNA_anti-codonNA-bd_OB_tRNAPfam
cd00776AsxRS_coreCDD
cd04318EcAsnRS_like_NCDD
PS50862AA_TRNA_LIGASE_IIaa-tRNA-synth_IIPROSITE profiles
PR01042TRNASYNTHASPAsp/Asn-tRNA-synth_IIbPRINTS
G3DSA:3.30.930.10:FF:000016CATH-FunFam
G3DSA:2.40.50.140NA-bd_OB-foldCATH-Gene3D
G3DSA:3.30.930.10aa-tRNA-synth_II/BPL/LPLCATH-Gene3D
SSF50249NA-bd_OB-foldSUPERFAMILY
SSF55681aa-tRNA-synth_II/BPL/LPLSUPERFAMILY
PTHR22594PANTHER
NF003037asnSNCBIFAM
TIGR00457asnSAsn-tRNA-ligaseNCBIFAM

Orthologs

References / Literature

GO_REF:0000002 - Comments
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:31474649 - Identification of 15 New Bypassable Essential Genes of Fission Yeast.
Takeda A et al. Cell Struct Funct 2019 Sep 27;44(2):113-119
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:30824696 - Systematic analysis reveals the prevalence and principles of bypassable gene essentiality.
Li J et al. Nat Commun 2019 Mar 01;10(1):1002
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.