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protein coding gene - mfr1 (SPBC1198.12) - meiotic APC activator Mfr1

Gene summary

Standard name
mfr1
Systematic ID
SPBC1198.12
Product
meiotic APC activator Mfr1
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
SPBC660.02, fzr1
UniProt ID
O94423
ORFeome ID
22/22H02
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 194678..195989 forward strand

Annotation

Comment

PBO:0091288 - meiosis specific splicing

References:

Disease association

MONDO:0859325 - developmental and epileptic encephalopathy 109

References:

GO biological process

GO:0031145 - anaphase-promoting complex-dependent catabolic process

References:

GO:1990950 - metaphase/anaphase transition of meiosis II

References:

GO:0051446 - positive regulation of meiotic cell cycle

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GO cellular component

GO:0005680 - anaphase-promoting complex

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GO molecular function

GO:0010997 - anaphase-promoting complex binding

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GO:0005515 - protein binding

References:

GO:1990757 - ubiquitin ligase activator activity

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Modification

MOD:00046 - O-phospho-L-serine

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Multi-locus phenotype

FYPO:0003379 - abolished meiosis II

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Genotypes:

FYPO:0003380 - decreased frequency of meiosis I

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Genotypes:

FYPO:0004994 - delayed onset of meiosis I

References:

Genotypes:

FYPO:0005412 - delayed onset of meiosis II

References:

Genotypes:

FYPO:0003611 - increased protein level during meiosis

References:

Genotypes:

FYPO:0005384 - meiosis I metaphase/anaphase transition delay

References:

Genotypes:

FYPO:0000478 - normal meiosis

References:

Genotypes:

Protein features

PBO:0111750 - Cdc20/Fizzy subfamily

PBO:0111909 - WD repxeat protein

Qualitative gene expression

PomGeneEx:0000022 - protein absent

References:

PomGeneEx:0000019 - protein level decreased

References:

PomGeneEx:0000018 - protein level increased

References:

PomGeneEx:0000021 - protein present

References:

PomGeneEx:0000015 - RNA absent

References:

PomGeneEx:0000012 - RNA level decreased

References:

PomGeneEx:0000011 - RNA level increased

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PomGeneEx:0000014 - RNA present

References:

Quantitative gene expression

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0003138 - abnormal ascospore wall morphology

References:

Genotypes:

FYPO:0001914 - abnormal prospore membrane formation

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Genotypes:

FYPO:0003066 - abnormal sporulation resulting in formation of ascus with fewer than four spores

References:

Genotypes:

FYPO:0009073 - decreased cell population growth on lysine nitrogen source

References:

Genotypes:

FYPO:0000584 - decreased sporulation frequency

References:

Genotypes:

FYPO:0005412 - delayed onset of meiosis II

References:

Genotypes:

FYPO:0000587 - delayed onset of sporulation

References:

Genotypes:

FYPO:0002221 - increased duration of meiotic anaphase II

References:

Genotypes:

FYPO:0003611 - increased protein level during meiosis

References:

Genotypes:

FYPO:0002151 - inviable spore

References:

Genotypes:

FYPO:0003797 - normal conjugation frequency

References:

Genotypes:

FYPO:0005383 - normal duration of meiosis I

References:

Genotypes:

FYPO:0000478 - normal meiosis

References:

Genotypes:

FYPO:0003176 - normal meiotic chromosome segregation

References:

Genotypes:

FYPO:0003905 - normal meiotic spindle pole body morphology during meiosis II

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Genotypes:

FYPO:0002043 - normal premeiotic DNA replication

References:

Genotypes:

FYPO:0000763 - resistance to cadmium

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Genotypes:

FYPO:0000095 - sensitive to bleomycin

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Genotypes:

FYPO:0007931 - sensitive to egtazic acid

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Genotypes:

FYPO:0000088 - sensitive to hydroxyurea

References:

Genotypes:

FYPO:0001719 - sensitive to lithium

References:

Genotypes:

FYPO:0002773 - third meiotic division

References:

Genotypes:

FYPO:0003612 - viable spore population

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF24807WD40_CDC20-FzWD40_CDC20-FzPFAM
PS50294WD_REPEATS_REGIONPROSITE_PROFILES
PS50082WD_REPEATS_2WD40_rptPROSITE_PROFILES
SM00320WD40_4WD40_rptSMART
SSF50978WD40 repeat-likeWD40_repeat_dom_sfSUPERFAMILY
G3DSA:2.130.10.10WD40/YVTN_repeat-like_dom_sfGENE3D
PTHR19918CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATEDCdc20/FizzyPANTHER
mobidb-lite-Disorderdisorder_predictionMOBIDB-Disorder
mobidb-lite-Polardisorder_predictionMOBIDB-Polar

Orthologs

References / Literature

PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:15791259 - Fission yeast Mes1p ensures the onset of meiosis II by blocking degradation of cyclin Cdc13p.
Izawa D et al. Nature 2005 Mar 24;434(7032):529-33
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:19547744 - Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.
Beltrao P et al. PLoS Biol 2009 Jun 16;7(6):e1000134
PMID:18331722 - A mutual inhibition between APC/C and its substrate Mes1 required for meiotic progression in fission yeast.
Kimata Y et al. Dev Cell 2008 Mar;14(3):446-54
PMID:23050226 - A genetic screen to discover pathways affecting cohesin function in Schizosaccharomyces pombe identifies chromatin effectors.
Chen Z et al. G3 (Bethesda) 2012 Oct;2(10):1161-8
PMID:11493649 - Fission yeast mfr1 activates APC and coordinates meiotic nuclear division with sporulation.
Blanco MA et al. J Cell Sci 2001 Jun;114(Pt 11):2135-43
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:23628763 - Cuf2 boosts the transcription of APC/C activator Fzr1 to terminate the meiotic division cycle.
Aoi Y et al. EMBO Rep 2013 Jun;14(6):553-60
PMID:15893732 - Negative control contributes to an extensive program of meiotic splicing in fission yeast.
Averbeck N et al. Mol Cell 2005 May 13;18(4):491-8
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:11405625 - A novel Cdc20-related WD-repeat protein, Fzr1, is required for spore formation in Schizosaccharomyces pombe.
Asakawa H et al. Mol Genet Genomics 2001 May;265(3):424-35
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:20826461 - The role of Schizosaccharomyces pombe dma1 in spore formation during meiosis.
Krapp A et al. J Cell Sci 2010 Oct 01;123(Pt 19):3284-93
PMID:21389117 - Mes1 controls the meiosis I to meiosis II transition by distinctly regulating the anaphase-promoting complex/cyclosome coactivators Fzr1/Mfr1 and Slp1 in fission yeast.
Kimata Y et al. Mol Biol Cell 2011 May;22(9):1486-94
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.
Mata J et al. Nat Genet 2002 Sep;32(1):143-7
PMID:21504829 - Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.
Stewart EV et al. Mol Cell 2011 Apr 22;42(2):160-71
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:28245054 - Fission yeast APC/C activators Slp1 and Fzr1 sequentially trigger two consecutive nuclear divisions during meiosis.
Chikashige Y et al. FEBS Lett 2017 Apr;591(7):1029-1040
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105