protein coding gene - fbp1 (SPBC1198.14c) - fructose-1,6-bisphosphatase Fbp1

Gene summary

Standard name

fbp1

Systematic ID

SPBC1198.14c

Product

fructose-1,6-bisphosphatase Fbp1

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

SPBC660.04c

UniProt ID

P09202

ORFeome ID

40/40C06

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome II: 197660..199415 reverse strand

Annotation

Protein features

Orthologs

• FBP1 (HGNC:3606) Homo sapiens
• FBP2 (HGNC:3607) Homo sapiens
• FBP1 (YLR377C) Saccharomyces cerevisiae

References / Literature

PMID:11014802 - Glucose monitoring in fission yeast via the Gpa2 galpha, the git5 Gbeta and the git3 putative glucose receptor.

Welton RM et al. Genetics 2000 Oct;156(2):513-21

PMID:1849107 - Glucose repression of transcription of the Schizosaccharomyces pombe fbp1 gene occurs by a cAMP signaling pathway.

Hoffman CS et al. Genes Dev 1991 Apr;5(4):561-71

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:9829945 - Methionine induces sexual development in the fission yeast Schizosaccharomyces pombe via an ste11-dependent signalling pathway.

Schweingruber AM et al. J Bacteriol 1998 Dec;180(23):6338-41

PMID:8552099 - Schizosaccharomyces pombe pcr1+ encodes a CREB/ATF protein involved in regulation of gene expression for sexual development.

Watanabe Y et al. Mol Cell Biol 1996 Feb;16(2):704-11

PMID:2558974 - A transcriptionally regulated expression vector for the fission yeast Schizosaccharomyces pombe.

Hoffman CS et al. Gene 1989 Dec 14;84(2):473-9

PMID:7589895 - Liver fructose-1,6-bisphosphatase cDNA: trans-complementation of fission yeast and characterization of two human transcripts.

Bertolotti R et al. Differentiation 1995 Jul;59(1):51-60

PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.

Mata J et al. Nat Genet 2002 Sep;32(1):143-7

PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.

Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895

PMID:24224056 - The transcription factors Atf1 and Pcr1 are essential for transcriptional induction of the extracellular maltase Agl1 in fission yeast.

Kato H et al. PLoS One 2013;8(11):e80572

PMID:41916008 - The RNA molecule or the transcription process: which is critical in the regulation of fbp1 gene activation mediated by metabolic stress-induced lncRNA (mlonRNA) in fission yeast.

Oe H et al. Biochem Biophys Res Commun 2026 Mar 26;815:153674

PMID:21828039 - Mfc1 is a novel forespore membrane copper transporter in meiotic and sporulating cells.

Beaudoin J et al. J Biol Chem 2011 Sep 30;286(39):34356-72

PMID:22730331 - Dual recruitment of Cdc48 (p97)-Ufd1-Npl4 ubiquitin-selective segregase by small ubiquitin-like modifier protein (SUMO) and ubiquitin in SUMO-targeted ubiquitin ligase-mediated genome stability functions.

Nie M et al. J Biol Chem 2012 Aug 24;287(35):29610-9

PMID:7862141 - The sak1+ gene of Schizosaccharomyces pombe encodes an RFX family DNA-binding protein that positively regulates cyclic AMP-dependent protein kinase-mediated exit from the mitotic cell cycle.

Wu SY et al. Mol Cell Biol 1995 Mar;15(3):1479-88

PMID:2987220 - Isolation of the fructose-1,6-bisphosphatase gene of the yeast Schizosaccharomyces pombe. Evidence for transcriptional regulation.

Vassarotti A et al. J Biol Chem 1985 May 25;260(10):6348-53

PMID:22840777 - Analyzing fission yeast multidrug resistance mechanisms to develop a genetically tractable model system for chemical biology.

Kawashima SA et al. Chem Biol 2012 Jul 27;19(7):893-901

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

PMID:29967244 - Histone Chaperone Asf1 Is Required for the Establishment of Repressive Chromatin in Schizosaccharomyces pombe fbp1 Gene Repression.

Umeda M et al. Mol Cell Biol 2018 Sep 15;38(18)

PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.

Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963

PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.

Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160

PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.

Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101

PMID:35286671 - Methods to Assess Phosphodiesterase and/or Adenylyl Cyclase Activity Via Heterologous Expression in Fission Yeast.

Domin M et al. Methods Mol Biol 2022;2483:93-104

PMID:41974504 - Nuclear basket subunits Nup211 and Rsm1 influence RNA 3'-processing and transcription termination in fission yeast.

Bednor L et al. RNA 2026 Apr 13;

PMID:34984977 - Functional profiling of long intergenic non-coding RNAs in fission yeast.

Rodriguez-Lopez M et al. Elife 2022 Jan 05;11

PMID:2834361 - Characterization of the gene for fructose-1,6-bisphosphatase from Saccharomyces cerevisiae and Schizosaccharomyces pombe. Sequence, protein homology, and expression during growth on glucose.

Rogers DT et al. J Biol Chem 1988 May 05;263(13):6051-7

PMID:11739717 - Protein kinase A regulates sexual development and gluconeogenesis through phosphorylation of the Zn finger transcriptional activator Rst2p in fission yeast.

Higuchi T et al. Mol Cell Biol 2002 Jan;22(1):1-11

PMID:31626996 - Multiplexed proteome profiling of carbon source perturbations in two yeast species with SL-SP3-TMT.

Paulo JA et al. J Proteomics 2020 Jan 06;210:103531

PMID:20531409 - Global coordination of transcriptional control and mRNA decay during cellular differentiation.

Amorim MJ et al. Mol Syst Biol 2010 Jun 08;6:380

PMID:9372444 - A zinc finger protein required for stationary phase viability in fission yeast.

Hao Z et al. J Cell Sci 1997 Oct;110 ( Pt 20):2557-66

PMID:28674280 - Interplay between chromatin modulators and histone acetylation regulates the formation of accessible chromatin in the upstream regulatory region of fission yeast fbp1.

Adachi A et al. Genes Genet Syst 2018 May 03;92(6):267-276

PMID:8001792 - Glucose repression of fbp1 transcription of Schizosaccharomyces pombe is partially regulated by adenylate cyclase activation by a G protein alpha subunit encoded by gpa2 (git8).

Nocero M et al. Genetics 1994 Sep;138(1):39-45

PMID:27887640 - Functional and regulatory profiling of energy metabolism in fission yeast.

Malecki M et al. Genome Biol 2016 Nov 25;17(1):240

PMID:20200159 - The LAMMER kinase homolog, Lkh1, regulates Tup transcriptional repressors through phosphorylation in Schizosaccharomyces pombe.

Kang WH et al. J Biol Chem 2010 Apr 30;285(18):13797-806

PMID:24297439 - Sck1 negatively regulates Gpa2-mediated glucose signaling in Schizosaccharomyces pombe.

Mudge DK et al. Eukaryot Cell 2014 Feb;13(2):202-8

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:22140232 - Snf1-like protein kinase Ssp2 regulates glucose derepression in Schizosaccharomyces pombe.

Matsuzawa T et al. Eukaryot Cell 2012 Feb;11(2):159-67

PMID:22370953 - Promotion of glycerol utilization using ethanol and 1-propanol in Schizosaccharomyces pombe.

Matsuzawa T et al. Appl Microbiol Biotechnol 2012 Jul;95(2):441-9

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.

PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.

Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684

PMID:18430926 - Schizosaccharomyces pombe Hsp90/Git10 is required for glucose/cAMP signaling.

Alaamery MA et al. Genetics 2008 Apr;178(4):1927-36

PMID:9535817 - Isolation and characterization of an invertase and its repressor genes from Schizosaccharomyces pombe.

Tanaka N et al. Biochem Biophys Res Commun 1998 Apr 07;245(1):246-53

PMID:10567571 - Conservation of histone binding and transcriptional repressor functions in a Schizosaccharomyces pombe Tup1p homolog.

Mukai Y et al. Mol Cell Biol 1999 Dec;19(12):8461-8

PMID:38252660 - Metabolic stress-induced long ncRNA transcription governs the formation of meiotic DNA breaks in the fission yeast fbp1 gene.

Tsuruta Y et al. PLoS One 2024;19(1):e0294191

PMID:36358992 - Multi-Layered Regulations on the Chromatin Architectures: Establishing the Tight and Specific Responses of Fission Yeast fbp1 Gene Transcription.

Asada R et al. Biomolecules 2022 Nov 05;12(11)

PMID:18818364 - Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast.

Roguev A et al. Science 2008 Oct 17;322(5900):405-10

PMID:18820678 - Stepwise chromatin remodelling by a cascade of transcription initiation of non-coding RNAs.

Hirota K et al. Nature 2008 Nov 06;456(7218):130-4

PMID:19266076 - Pro-aging effects of glucose signaling through a G protein-coupled glucose receptor in fission yeast.

Roux AE et al. PLoS Genet 2009 Mar;5(3):e1000408

PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.

Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399

PMID:29432178 - General amino acid control in fission yeast is regulated by a nonconserved transcription factor, with functions analogous to Gcn4/Atf4.

Duncan CDS et al. Proc Natl Acad Sci U S A 2018 Feb 20;115(8):E1829-E1838

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:23173672 - Identification of novel genes involved in DNA damage response by screening a genome-wide Schizosaccharomyces pombe deletion library.

Pan X et al. BMC Genomics 2012 Nov 23;13:662

PMID:28934464 - Recruitment and delivery of the fission yeast Rst2 transcription factor via a local genome structure counteracts repression by Tup1-family corepressors.

Asada R et al. Nucleic Acids Res 2017 Sep 19;45(16):9361-9371

PMID:2157626 - Isolation and characterization of mutants constitutive for expression of the fbp1 gene of Schizosaccharomyces pombe.

Hoffman CS et al. Genetics 1990 Apr;124(4):807-16

PMID:27918601 - Identifying genes required for respiratory growth of fission yeast.

Malecki M et al. Wellcome Open Res 2016;1:12

PMID:15189983 - Suppressors of an adenylate cyclase deletion in the fission yeast Schizosaccharomyces pombe.

Stiefel J et al. Eukaryot Cell 2004 Jun;3(3):610-9

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:8832415 - The wis1 signal transduction pathway is required for expression of cAMP-repressed genes in fission yeast.

Stettler S et al. J Cell Sci 1996 Jul;109 ( Pt 7):1927-35

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:11238405 - Transcriptional regulators of the Schizosaccharomyces pombe fbp1 gene include two redundant Tup1p-like corepressors and the CCAAT binding factor activation complex.

Janoo RT et al. Genetics 2001 Mar;157(3):1205-15