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protein coding gene - rsp1 (SPBC11B10.05c) - random septum position protein, DNAJ domain protein Rsp1

Gene summary

Standard name
rsp1
Systematic ID
SPBC11B10.05c
Product
random septum position protein, DNAJ domain protein Rsp1
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
pi006, SPACTOKYO_453.30c
UniProt ID
O13601
ORFeome ID
50/50G05
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 1493052..1495427 reverse strand

Annotation

Disease association

MONDO:0008083 - ceroid lipofuscinosis, neuronal, 4 (Kufs type)

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GO biological process

GO:0031122 - cytoplasmic microtubule organization

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GO:0031025 - equatorial microtubule organizing center disassembly

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GO:0031024 - interphase microtubule organizing center assembly

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GO:0042026 - protein refolding

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GO cellular component

GO:0032153 - cell division site

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GO:0005737 - cytoplasm

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GO:1904511 - cytoplasmic microtubule plus-end

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GO:0000923 - equatorial microtubule organizing center

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GO:0031021 - interphase microtubule organizing center

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GO:0044732 - mitotic spindle pole body

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GO:0005816 - spindle pole body

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GO molecular function

GO:0030544 - Hsp70 protein binding

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GO:0005515 - protein binding

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Miscellaneous functional group

PBO:0000255 - chaperone

Modification

MOD:00595 - monomannosylated residue

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MOD:00046 - O-phospho-L-serine

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MOD:00047 - O-phospho-L-threonine

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MOD:00696 - phosphorylated residue

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Qualitative gene expression

PomGeneEx:0000018 - protein level increased

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Quantitative gene expression

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0001126 - abnormal cell shape

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Genotypes:

FYPO:0000234 - abnormal cytoplasmic interphase microtubule nucleation

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Genotypes:

FYPO:0005558 - abnormal microtubule bundle

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Genotypes:

FYPO:0000935 - abnormal protein localization to cortical microtubule cytoskeleton during vegetative growth

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Genotypes:

FYPO:0004090 - abnormal protein localization to microtubule cytoskeleton

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Genotypes:

FYPO:0000121 - abnormal sporulation

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Genotypes:

FYPO:0004624 - abolished eMTOC assembly

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Genotypes:

FYPO:0007984 - abolished eMTOC disassembly

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Genotypes:

FYPO:0005441 - abolished protein localization to microtubule during mitotic interphase

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Genotypes:

FYPO:0006220 - abolished protein localization to septum

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Genotypes:

FYPO:0000705 - abolished protein-protein interaction

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Genotypes:

FYPO:0006182 - decreased protein localization to interphase microtubule

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Genotypes:

FYPO:0007985 - early eMTOC assembly

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Genotypes:

FYPO:0003337 - increased protein localization to septum

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Genotypes:

FYPO:0004511 - long curved interphase microtubules

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Genotypes:

FYPO:0006518 - loss of viability in G0

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Genotypes:

FYPO:0007983 - microtubule bundles detached from the nuclear envelope

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Genotypes:

FYPO:0002818 - microtubule bundles present in decreased numbers

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Genotypes:

FYPO:0005686 - microtubule bundles present in decreased numbers during mitotic interphase

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Genotypes:

FYPO:0000339 - mislocalized septum during vegetative growth

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Genotypes:

FYPO:0000276 - monopolar mitotic spindle

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Genotypes:

FYPO:0007553 - normal G1 to G0 transition

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Genotypes:

FYPO:0007114 - normal microtubule bundle

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Genotypes:

FYPO:0004083 - normal protein level

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Genotypes:

FYPO:0000703 - normal protein-protein interaction

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Genotypes:

FYPO:0003302 - nucleus mislocalized towards cell tip during mitotic interphase

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Genotypes:

FYPO:0000764 - resistance to cycloheximide

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Genotypes:

FYPO:0006680 - sensitive to bisphenol A

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Genotypes:

FYPO:0000095 - sensitive to bleomycin

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Genotypes:

FYPO:0000096 - sensitive to cadmium

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Genotypes:

FYPO:0009086 - sensitive to lithium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0009088 - sensitive to magnesium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0001457 - sensitive to tunicamycin

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Genotypes:

FYPO:0007982 - single microtubule bundle with aster-like microtubules

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Genotypes:

FYPO:0002112 - viable curved vegetative cell

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

Protein features

IDNameInterPro nameDB name
PF00226DnaJDnaJ_domainPFAM
cd06257DnaJDnaJ_domainCDD
PS00636DNAJ_1DnaJ_domain_CSPROSITE_PATTERNS
PS50076DNAJ_2DnaJ_domainPROSITE_PROFILES
SM00271dnaj_3DnaJ_domainSMART
PR00625JDOMAINDnaJ_domainPRINTS
SSF46565Chaperone J-domainJ_dom_sfSUPERFAMILY
G3DSA:1.10.287.110DnaJ domainJ_dom_sfGENE3D
PTHR44029DNAJ HOMOLOG SUBFAMILY C MEMBER 21Chaperone_stress_responsePANTHER
mobidb-lite-Disorderdisorder_predictionMOBIDB-Disorder
mobidb-lite-Low-complexitydisorder_predictionMOBIDB-Low-complexity
mobidb-lite-Polardisorder_predictionMOBIDB-Polar

Orthologs

References / Literature

PMID:15068790 - Rsp1p, a J domain protein required for disassembly and assembly of microtubule organizing centers during the fission yeast cell cycle.
Zimmerman S et al. Dev Cell 2004 Apr;6(4):497-509
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:26644575 - Discovery of a nucleocytoplasmic O-mannose glycoproteome in yeast.
Halim A et al. Proc Natl Acad Sci U S A 2015 Dec 22;112(51):15648-53
PMID:15837798 - Efficient formation of bipolar microtubule bundles requires microtubule-bound gamma-tubulin complexes.
Janson ME et al. J Cell Biol 2005 Apr 25;169(2):297-308
PMID:27298342 - Identification of S-phase DNA damage-response targets in fission yeast reveals conservation of damage-response networks.
Willis NA et al. Proc Natl Acad Sci U S A 2016 Jun 28;113(26):E3676-85
PMID:29259000 - Genes Important for Schizosaccharomyces pombe Meiosis Identified Through a Functional Genomics Screen.
Blyth J et al. Genetics 2018 Feb;208(2):589-603
PMID:30427751 - The J-domain cochaperone Rsp1 interacts with Mto1 to organize noncentrosomal microtubule assembly.
Shen J et al. Mol Biol Cell 2019 Jan 15;30(2):256-267
PMID:15797925 - The nuclear rim protein Amo1 is required for proper microtubule cytoskeleton organisation in fission yeast.
Pardo M et al. J Cell Sci 2005 Apr 15;118(Pt 8):1705-14
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:30647105 - Comparative Genomic Screen in Two Yeasts Reveals Conserved Pathways in the Response Network to Phenol Stress.
Alhoch B et al. G3 (Bethesda) 2019 Mar 07;9(3):639-650
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:33260998 - High-Throughput Flow Cytometry Combined with Genetic Analysis Brings New Insights into the Understanding of Chromatin Regulation of Cellular Quiescence.
Zahedi Y et al. Int J Mol Sci 2020 Nov 27;21(23)
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:23050226 - A genetic screen to discover pathways affecting cohesin function in Schizosaccharomyces pombe identifies chromatin effectors.
Chen Z et al. G3 (Bethesda) 2012 Oct;2(10):1161-8
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.
Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6