protein coding gene - cdc2 (SPBC11B10.09) - cyclin-dependent protein kinase Cdk1/Cdc2

Gene summary

Standard name

cdc2

Systematic ID

SPBC11B10.09

Product

cyclin-dependent protein kinase Cdk1/Cdc2

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

cdk1, pi002, SPACTOKYO_453.34, swo2, wee2

UniProt ID

P04551

ORFeome ID

50/50D08

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome II: 1500208..1502095 forward strand

Annotation

Protein features

Orthologs

• CDK1 (HGNC:1722) Homo sapiens
• CDK2 (HGNC:1771) Homo sapiens
• CDK3 (HGNC:1772) Homo sapiens
• cdc2 (SJAG_03048) Schizosaccharomyces japonicus
• CDC28 (YBR160W) Saccharomyces cerevisiae

References / Literature

PMID:1703321 - Complementation of the mitotic activator, p80cdc25, by a human protein-tyrosine phosphatase.

Gould KL et al. Science 1990 Dec 14;250(4987):1573-6

PMID:8437586 - Mutational analysis of the fission yeast p34cdc2 protein kinase gene.

MacNeill SA et al. Mol Gen Genet 1993 Jan;236(2-3):415-26

PMID:9490640 - A NIMA homologue promotes chromatin condensation in fission yeast.

Krien MJ et al. J Cell Sci 1998 Apr;111 ( Pt 7):967-76

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

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PMID:22438582 - Spindle pole body components are reorganized during fission yeast meiosis.

Ohta M et al. Mol Biol Cell 2012 May;23(10):1799-811

PMID:15335873 - Mitotic regulation of protein phosphatases by the fission yeast sds22 protein.

Stone EM et al. Curr Biol 1993 Jan;3(1):13-26

PMID:12167173 - Combinatorial diversity of fission yeast SCF ubiquitin ligases by homo- and heterooligomeric assemblies of the F-box proteins Pop1p and Pop2p.

Seibert V et al. BMC Biochem 2002 Aug 07;3:22

PMID:8621436 - A conditional lethal mutant in the fission yeast 26 S protease subunit mts3+ is defective in metaphase to anaphase transition.

Gordon C et al. J Biol Chem 1996 Mar 08;271(10):5704-11

PMID:8455610 - Two fission yeast B-type cyclins, cig2 and Cdc13, have different functions in mitosis.

Bueno A et al. Mol Cell Biol 1993 Apr;13(4):2286-97

PMID:24006256 - Fission yeast nucleolar protein Dnt1 regulates G2/M transition and cytokinesis by downregulating Wee1 kinase.

Yu ZY et al. J Cell Sci 2013 Nov 01;126(Pt 21):4995-5004

PMID:15911625 - Functional homology among human and fission yeast Cdc14 phosphatases.

Vázquez-Novelle MD et al. J Biol Chem 2005 Aug 12;280(32):29144-50

PMID:19546237 - TOR complex 2 controls gene silencing, telomere length maintenance, and survival under DNA-damaging conditions.

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PMID:22451489 - Cyclin-dependent kinase 8 regulates mitotic commitment in fission yeast.

Szilagyi Z et al. Mol Cell Biol 2012 Jun;32(11):2099-109

PMID:22645648 - The reverse, but coordinated, roles of Tor2 (TORC1) and Tor1 (TORC2) kinases for growth, cell cycle and separase-mediated mitosis in Schizosaccharomyces pombe.

Ikai N et al. Open Biol 2011 Nov;1(3):110007

PMID:9135148 - p56(chk1) protein kinase is required for the DNA replication checkpoint at 37 degrees C in fission yeast.

Francesconi S et al. EMBO J 1997 Mar 17;16(6):1332-41

PMID:2674650 - Molecular cloning and sequence analysis of mutant alleles of the fission yeast cdc2 protein kinase gene: implications for cdc2+ protein structure and function.

Carr AM et al. Mol Gen Genet 1989 Jul;218(1):41-9

PMID:9383051 - Mcs4, a two-component system response regulator homologue, regulates the Schizosaccharomyces pombe cell cycle control.

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PMID:7501024 - Cell-cycle control linked to extracellular environment by MAP kinase pathway in fission yeast.

Shiozaki K et al. Nature 1995 Dec 14;378(6558):739-43

PMID:762020 - Uncontrolled septation in a cell division cycle mutant of the fission yeast Schizosaccharomyces pombe.

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PMID:8598285 - Rum1 and Cdc18 link inhibition of cyclin-dependent kinase to the initiation of DNA replication in Schizosaccharomyces pombe.

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PMID:9917066 - Molecular genetic analysis of U2AF59 in Schizosaccharomyces pombe: differential sensitivity of introns to mutational inactivation.

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PMID:22615807 - Crystal structures of Lsm3, Lsm4 and Lsm5/6/7 from Schizosaccharomyces pombe.

Wu D et al. PLoS One 2012;7(5):e36768

PMID:15791259 - Fission yeast Mes1p ensures the onset of meiosis II by blocking degradation of cyclin Cdc13p.

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PMID:19366728 - Genetic control of cellular quiescence in S. pombe.

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PMID:19547744 - Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

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PMID:26912660 - Gad8 Protein Is Found in the Nucleus Where It Interacts with the MluI Cell Cycle Box-binding Factor (MBF) Transcriptional Complex to Regulate the Response to DNA Replication Stress.

Cohen A et al. J Biol Chem 2016 Apr 22;291(17):9371-81

PMID:29813053 - Specific detection of fission yeast primary septum reveals septum and cleavage furrow ingression during early anaphase independent of mitosis completion.

G Cortés JC et al. PLoS Genet 2018 May;14(5):e1007388

PMID:15731009 - Ste20/GCK kinase Nak1/Orb3 polarizes the actin cytoskeleton in fission yeast during the cell cycle.

Leonhard K et al. J Cell Sci 2005 Mar 01;118(Pt 5):1033-44

PMID:21098641 - Regulation of cell cycle-specific gene expression in fission yeast by the Cdc14p-like phosphatase Clp1p.

Papadopoulou K et al. J Cell Sci 2010 Dec 15;123(Pt 24):4374-81

PMID:1316996 - Cold-sensitive mutants of p34cdc2 that suppress a mitotic catastrophe phenotype in fission yeast.

Ayscough K et al. Mol Gen Genet 1992 Apr;232(3):344-50

PMID:15297457 - On the slowing of S phase in response to DNA damage in fission yeast.

Kumar S et al. J Biol Chem 2004 Oct 15;279(42):43574-80

PMID:12606573 - Function of Cdc2p-dependent Bub1p phosphorylation and Bub1p kinase activity in the mitotic and meiotic spindle checkpoint.

Yamaguchi S et al. EMBO J 2003 Mar 03;22(5):1075-87

PMID:16920624 - CDC2 phosphorylation of the fission yeast dis1 ensures accurate chromosome segregation.

Aoki K et al. Curr Biol 2006 Aug 22;16(16):1627-35

PMID:9136929 - The Mcs4 response regulator coordinately controls the stress-activated Wak1-Wis1-Sty1 MAP kinase pathway and fission yeast cell cycle.

Shieh JC et al. Genes Dev 1997 Apr 15;11(8):1008-22

PMID:12135745 - Cmk2, a novel serine/threonine kinase in fission yeast.

Alemany V et al. FEBS Lett 2002 Jul 31;524(1-3):79-86

PMID:8041632 - SCR: novel human suppressors of cdc2/cdc13 mutants of Schizosaccharomyces pombe harbour motifs for RNA binding proteins.

Kanaoka Y et al. Nucleic Acids Res 1994 Jul 11;22(13):2687-93

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:19474789 - A spatial gradient coordinates cell size and mitotic entry in fission yeast.

Moseley JB et al. Nature 2009 Jun 11;459(7248):857-60

PMID:9278510 - Cdc25 mitotic inducer targeted by chk1 DNA damage checkpoint kinase.

Furnari B et al. Science 1997 Sep 05;277(5331):1495-7

PMID:9473044 - Coordination of initiation of nuclear division and initiation of cell division in Schizosaccharomyces pombe: genetic interactions of mutations.

Grallert A et al. J Bacteriol 1998 Feb;180(4):892-900

PMID:27736299 - A genome-wide screen to identify genes controlling the rate of entry into mitosis in fission yeast.

Moris N et al. Cell Cycle 2016 Nov 16;15(22):3121-3130

PMID:11163211 - The spike of S phase cyclin Cig2 expression at the G1-S border in fission yeast requires both APC and SCF ubiquitin ligases.

Yamano H et al. Mol Cell 2000 Dec;6(6):1377-87

PMID:1829983 - A fission yeast B-type cyclin functioning early in the cell cycle.

Bueno A et al. Cell 1991 Jul 12;66(1):149-59

PMID:18474252 - Crosstalk between Nap1 protein and Cds1 checkpoint kinase to maintain chromatin integrity.

Grande M et al. Biochim Biophys Acta 2008 Sep;1783(9):1595-604

PMID:14985109 - Cdk inhibitor ste9p/srw1p is involved in response to protein synthesis inhibition in fission yeast.

Sakai T Biochem Biophys Res Commun 2004 Mar 19;315(4):984-90

PMID:2320127 - Regulation of mitosis by cyclic accumulation of p80cdc25 mitotic inducer in fission yeast.

Moreno S et al. Nature 1990 Apr 05;344(6266):549-52

PMID:39174851 - CDK phosphorylation of Sfr1 downregulates Rad51 function in late-meiotic homolog invasions.

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PMID:8946912 - The dmf1/mid1 gene is essential for correct positioning of the division septum in fission yeast.

Sohrmann M et al. Genes Dev 1996 Nov 01;10(21):2707-19

PMID:2406029 - Mutation of fission yeast cell cycle control genes abolishes dependence of mitosis on DNA replication.

Enoch T et al. Cell 1990 Feb 23;60(4):665-73

PMID:9353247 - Regulation of the replication initiator protein p65cdc18 by CDK phosphorylation.

Jallepalli PV et al. Genes Dev 1997 Nov 01;11(21):2767-79

PMID:3322810 - p13suc1 acts in the fission yeast cell division cycle as a component of the p34cdc2 protein kinase.

Brizuela L et al. EMBO J 1987 Nov;6(11):3507-14

PMID:9560390 - Sum1, a highly conserved WD-repeat protein, suppresses S-M checkpoint mutants and inhibits the osmotic stress cell cycle response in fission yeast.

Humphrey T et al. Genetics 1998 Apr;148(4):1731-42

PMID:9843577 - The cdr2(+) gene encodes a regulator of G2/M progression and cytokinesis in Schizosaccharomyces pombe.

Breeding CS et al. Mol Biol Cell 1998 Dec;9(12):3399-415

PMID:12023299 - Cdc2-cyclin B kinase activity links Crb2 and Rqh1-topoisomerase III.

Caspari T et al. Genes Dev 2002 May 15;16(10):1195-208

PMID:9710608 - The role of fnx1, a fission yeast multidrug resistance protein, in the transition of cells to a quiescent G0 state.

Dimitrov K et al. Mol Cell Biol 1998 Sep;18(9):5239-46

PMID:34674264 - Localization of the ubiquitin ligase Dma1 to the fission yeast contractile ring is modulated by phosphorylation.

Chen JS et al. FEBS Lett 2021 Nov;595(22):2781-2792

PMID:10684278 - Genetic studies with the fission yeast Schizosaccharomyces pombe suggest involvement of wee1, ppa2, and rad24 in induction of cell cycle arrest by human immunodeficiency virus type 1 Vpr.

Masuda M et al. J Virol 2000 Mar;74(6):2636-46

PMID:24506453 - The RNA-binding protein Spo5 promotes meiosis II by regulating cyclin Cdc13 in fission yeast.

Arata M et al. Genes Cells 2014 Mar;19(3):225-38

PMID:10567589 - Characterization of a fission yeast SUMO-1 homologue, pmt3p, required for multiple nuclear events, including the control of telomere length and chromosome segregation.

Tanaka K et al. Mol Cell Biol 1999 Dec;19(12):8660-72

PMID:34402513 - Phosphorylation in the intrinsically disordered region of F-BAR protein Imp2 regulates its contractile ring recruitment.

Willet AH et al. J Cell Sci 2021 Aug 15;134(16)

PMID:1563349 - Checkpoint controls in Schizosaccharomyces pombe: rad1.

Rowley R et al. EMBO J 1992 Apr;11(4):1335-42

PMID:22144913 - Widespread cotranslational formation of protein complexes.

Duncan CD et al. PLoS Genet 2011 Dec;7(12):e1002398

PMID:28479325 - Size-Dependent Expression of the Mitotic Activator Cdc25 Suggests a Mechanism of Size Control in Fission Yeast.

Keifenheim D et al. Curr Biol 2017 May 22;27(10):1491-1497.e4

PMID:2908246 - Cloning and sequencing of the cyclin-related cdc13+ gene and a cytological study of its role in fission yeast mitosis.

Hagan I et al. J Cell Sci 1988 Dec;91 ( Pt 4):587-95

PMID:19686686 - Phospho-regulated interaction between kinesin-6 Klp9p and microtubule bundler Ase1p promotes spindle elongation.

Fu C et al. Dev Cell 2009 Aug;17(2):257-67

PMID:1655416 - Phosphorylation at Thr167 is required for Schizosaccharomyces pombe p34cdc2 function.

Gould KL et al. EMBO J 1991 Nov;10(11):3297-309

PMID:1699136 - Distinct nuclear and spindle pole body population of cyclin-cdc2 in fission yeast.

Alfa CE et al. Nature 1990 Oct 18;347(6294):680-2

PMID:28178520 - Identification of a Sgo2-Dependent but Mad2-Independent Pathway Controlling Anaphase Onset in Fission Yeast.

Meadows JC et al. Cell Rep 2017 Feb 07;18(6):1422-1433

PMID:15620657 - Ubiquitin-like protein Hub1 is required for pre-mRNA splicing and localization of an essential splicing factor in fission yeast.

Wilkinson CR et al. Curr Biol 2004 Dec 29;14(24):2283-8

PMID:36408846 - Differential phosphorylation of Clr4 SUV39H by Cdk1 accompanies a histone H3 methylation switch that is essential for gametogenesis.

Kuzdere T et al. EMBO Rep 2023 Jan 09;24(1):e55928

PMID:3032459 - Negative regulation of mitosis by wee1+, a gene encoding a protein kinase homolog.

Russell P et al. Cell 1987 May 22;49(4):559-67

PMID:39387272 - The DNA Damage Repair Function of Fission Yeast CK1 Involves Targeting Arp8, a Subunit of the INO80 Chromatin Remodeling Complex.

Cullati SN et al. Mol Cell Biol 2024 Oct 10;:1-15

PMID:7723827 - A kinase from fission yeast responsible for blocking mitosis in S phase.

Murakami H et al. Nature 1995 Apr 27;374(6525):817-9

PMID:2544292 - Involvement of a type 1 protein phosphatase encoded by bws1+ in fission yeast mitotic control.

Booher R et al. Cell 1989 Jun 16;57(6):1009-16

PMID:9115279 - Pch1(+), a second essential C-type cyclin gene in Schizosaccharomyces pombe.

Furnari BA et al. J Biol Chem 1997 May 02;272(18):12100-6

PMID:9571240 - Fission yeast Ste9, a homolog of Hct1/Cdh1 and Fizzy-related, is a novel negative regulator of cell cycle progression during G1-phase.

Kitamura K et al. Mol Biol Cell 1998 May;9(5):1065-80

PMID:11084332 - Cut8, essential for anaphase, controls localization of 26S proteasome, facilitating destruction of cyclin and Cut2.

Tatebe H et al. Curr Biol 2000 Nov 02;10(21):1329-38

PMID:21518960 - Mrc1 marks early-firing origins and coordinates timing and efficiency of initiation in fission yeast.

Hayano M et al. Mol Cell Biol 2011 Jun;31(12):2380-91

PMID:16390871 - Activity of Cdc2 and its interaction with the cyclin Cdc13 depend on the molecular chaperone Cdc37 in Schizosaccharomyces pombe.

Turnbull EL et al. J Cell Sci 2006 Jan 15;119(Pt 2):292-302

PMID:6581157 - A meiotic mutant of the fission yeast Schizosaccharomyces pombe that produces mature asci containing two diploid spores.

Nakaseko Y et al. J Bacteriol 1984 Jan;157(1):334-6

PMID:15062098 - Sid4p-Cdc11p assembles the septation initiation network and its regulators at the S. pombe SPB.

Morrell JL et al. Curr Biol 2004 Apr 06;14(7):579-84

PMID:9832516 - Suppressors of cdc25p overexpression identify two pathways that influence the G2/M checkpoint in fission yeast.

Forbes KC et al. Genetics 1998 Dec;150(4):1361-75

PMID:16453669 - Transcription of the cdc2 cell cycle control gene of the fission yeast Schizosaccharomyces pombe.

Durkacz B et al. EMBO J 1986 Feb;5(2):369-73

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:26527280 - Robust Ordering of Anaphase Events by Adaptive Thresholds and Competing Degradation Pathways.

Kamenz J et al. Mol Cell 2015 Nov 05;60(3):446-59

PMID:1899230 - Fission yeast genes that confer resistance to staurosporine encode an AP-1-like transcription factor and a protein kinase related to the mammalian ERK1/MAP2 and budding yeast FUS3 and KSS1 kinases.

Toda T et al. Genes Dev 1991 Jan;5(1):60-73

PMID:23370392 - A knockout screen for protein kinases required for the proper meiotic segregation of chromosomes in the fission yeast Schizosaccharomyces pombe.

Kovacikova I et al. Cell Cycle 2013 Feb 15;12(4):618-24

PMID:25375240 - The kinetochore protein Kis1/Eic1/Mis19 ensures the integrity of mitotic spindles through maintenance of kinetochore factors Mis6/CENP-I and CENP-A.

Hirai H et al. PLoS One 2014;9(11):e111905

PMID:35354597 - Quantitative analysis of nuclear pore complex organization in Schizosaccharomyces pombe .

Varberg JM et al. Life Sci Alliance 2022 Jul;5(7)

PMID:10226032 - Cdc2 activation in fission yeast depends on Mcs6 and Csk1, two partially redundant Cdk-activating kinases (CAKs).

Lee KM et al. Curr Biol 1999 Apr 22;9(8):441-4

PMID:10503548 - Analysis of the cps1 gene provides evidence for a septation checkpoint in Schizosaccharomyces pombe.

Le Goff X et al. Mol Gen Genet 1999 Aug;262(1):163-72

PMID:25691663 - Fission yeast Cdk7 controls gene expression through both its CAK and C-terminal domain kinase activities.

Devos M et al. Mol Cell Biol 2015 May;35(9):1480-90

PMID:11460168 - A MAP kinase-dependent actin checkpoint ensures proper spindle orientation in fission yeast.

Gachet Y et al. Nature 2001 Jul 19;412(6844):352-5

PMID:7626804 - The Wee1 protein kinase regulates T14 phosphorylation of fission yeast Cdc2.

Den Haese GJ et al. Mol Biol Cell 1995 Apr;6(4):371-85

PMID:24920823 - Cdk1 promotes cytokinesis in fission yeast through activation of the septation initiation network.

Rachfall N et al. Mol Biol Cell 2014 Aug 01;25(15):2250-9

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:16371652 - Production of reactive oxygen species in response to replication stress and inappropriate mitosis in fission yeast.

Marchetti MA et al. J Cell Sci 2006 Jan 01;119(Pt 1):124-31

PMID:22768388 - Translational control of cell division by Elongator.

Bauer F et al. Cell Rep 2012 May 31;1(5):424-33

PMID:30955932 - Noisy Cell-Size-Correlated Expression of Cyclin B Drives Probabilistic Cell-Size Homeostasis in Fission Yeast.

Patterson JO et al. Curr Biol 2019 Apr 22;29(8):1379-1386.e4

PMID:24074952 - Phosphorylation-dependent assembly and coordination of the DNA damage checkpoint apparatus by Rad4(TopBP1).

Qu M et al. Mol Cell 2013 Sep 26;51(6):723-736

PMID:8467814 - Characterization of the fission yeast mcs2 cyclin and its associated protein kinase activity.

Molz L et al. EMBO J 1993 Apr;12(4):1723-32

PMID:8978687 - The fission yeast dma1 gene is a component of the spindle assembly checkpoint, required to prevent septum formation and premature exit from mitosis if spindle function is compromised.

Murone M et al. EMBO J 1996 Dec 02;15(23):6605-16

PMID:26093291 - Long G2 accumulates recombination intermediates and disturbs chromosome segregation at dysfunction telomere in Schizosaccharomyces pombe.

Habib AG et al. Biochem Biophys Res Commun 2015 Aug 14;464(1):140-6

PMID:22291963 - Histone chaperone Asf1 plays an essential role in maintaining genomic stability in fission yeast.

Tanae K et al. PLoS One 2012;7(1):e30472

PMID:8121488 - Regulation of progression through the G1 phase of the cell cycle by the rum1+ gene.

Moreno S et al. Nature 1994 Jan 20;367(6460):236-42

PMID:16950131 - Phospho-regulation of the Cdc14/Clp1 phosphatase delays late mitotic events in S. pombe.

Wolfe BA et al. Dev Cell 2006 Sep;11(3):423-30

PMID:8170927 - Mutational analysis supports a structural model for the cell cycle protein kinase p34.

Endicott JA et al. Protein Eng 1994 Feb;7(2):243-53

PMID:2534559 - Fission yeast cyclin: subcellular localisation and cell cycle regulation.

Alfa CE et al. J Cell Sci Suppl 1989;12:9-19

PMID:8334307 - The Schizosaccharomyces pombe cdc14 gene is required for septum formation and can also inhibit nuclear division.

Fankhauser C et al. Mol Biol Cell 1993 May;4(5):531-9

PMID:8521500 - p25rum1 orders S phase and mitosis by acting as an inhibitor of the p34cdc2 mitotic kinase.

Correa-Bordes J et al. Cell 1995 Dec 15;83(6):1001-9

PMID:9614176 - Cyclin B proteolysis and the cyclin-dependent kinase inhibitor rum1p are required for pheromone-induced G1 arrest in fission yeast.

Stern B et al. Mol Biol Cell 1998 Jun;9(6):1309-21

PMID:32878942 - Phosphoregulation of the cytokinetic protein Fic1 contributes to fission yeast growth polarity establishment.

Bohnert KA et al. J Cell Sci 2020 Sep 17;133(18)

PMID:24861625 - Hyperactive Cdc2 kinase interferes with the response to broken replication forks by trapping S.pombe Crb2 in its mitotic T215 phosphorylated state.

Mahyous Saeyd SA et al. Nucleic Acids Res 2014 Jul;42(12):7734-47

PMID:1372994 - p107wee1 is a dual-specificity kinase that phosphorylates p34cdc2 on tyrosine 15.

Parker LL et al. Proc Natl Acad Sci U S A 1992 Apr 01;89(7):2917-21

PMID:15128870 - A role for the Cdc14-family phosphatase Flp1p at the end of the cell cycle in controlling the rapid degradation of the mitotic inducer Cdc25p in fission yeast.

Esteban V et al. J Cell Sci 2004 May 15;117(Pt 12):2461-8

PMID:23333317 - Removal of centrosomal PP1 by NIMA kinase unlocks the MPF feedback loop to promote mitotic commitment in S. pombe.

Grallert A et al. Curr Biol 2013 Feb 04;23(3):213-22

PMID:1934126 - Common genes and pathways in the regulation of the mitotic and meiotic cell cycles of Schizosaccharomyces pombe.

Grallert B et al. Curr Genet 1991 Aug;20(3):199-204

PMID:10921878 - Fission yeast Fizzy-related protein srw1p is a G(1)-specific promoter of mitotic cyclin B degradation.

Yamaguchi S et al. EMBO J 2000 Aug 01;19(15):3968-77

PMID:2682257 - Tyrosine phosphorylation of the fission yeast cdc2+ protein kinase regulates entry into mitosis.

Gould KL et al. Nature 1989 Nov 02;342(6245):39-45

PMID:27398807 - Functional Crosstalk between the PP2A and SUMO Pathways Revealed by Analysis of STUbL Suppressor, razor 1-1.

Nie M et al. PLoS Genet 2016 Jul;12(7):e1006165

PMID:10759889 - Large-scale screening of intracellular protein localization in living fission yeast cells by the use of a GFP-fusion genomic DNA library.

Ding DQ et al. Genes Cells 2000 Mar;5(3):169-90

PMID:30640914 - CDK contribution to DSB formation and recombination in fission yeast meiosis.

Bustamante-Jaramillo LF et al. PLoS Genet 2019 Jan;15(1):e1007876

PMID:38166399 - Fission yeast Wee1 is required for stable kinetochore-microtubule attachment.

Takado M et al. Open Biol 2024 Jan;14(1):230379

PMID:7957098 - Fission yeast cut5 links nuclear chromatin and M phase regulator in the replication checkpoint control.

Saka Y et al. EMBO J 1994 Nov 15;13(22):5319-29

PMID:24790095 - Characterization of the roles of Blt1p in fission yeast cytokinesis.

Goss JW et al. Mol Biol Cell 2014 Jul 01;25(13):1946-57

PMID:8319772 - In vivo phosphorylation, mitotic behavior, and nuclear binding of the catalytic subunit of DNA polymerase alpha in fission yeast.

Bouvier D et al. Exp Cell Res 1993 Jul;207(1):41-7

PMID:23297348 - Comprehensive proteomics analysis reveals new substrates and regulators of the fission yeast clp1/cdc14 phosphatase.

Chen JS et al. Mol Cell Proteomics 2013 May;12(5):1074-86

PMID:32084401 - The Hydrophobic Patch Directs Cyclin B to Centrosomes to Promote Global CDK Phosphorylation at Mitosis.

Basu S et al. Curr Biol 2020 Mar 09;30(5):883-892.e4

PMID:8389306 - Negative regulation of mitosis by the fission yeast protein phosphatase ppa2.

Kinoshita N et al. Genes Dev 1993 Jun;7(6):1059-71

PMID:9201720 - Ran1 functions to control the Cdc10/Sct1 complex through Puc1.

Caligiuri M et al. Mol Biol Cell 1997 Jun;8(6):1117-28

PMID:10704373 - A checkpoint that monitors cytokinesis in Schizosaccharomyces pombe.

Liu J et al. J Cell Sci 2000 Apr;113 ( Pt 7):1223-30

PMID:9552380 - Regulation of G1 progression in fission yeast by the rum1+ gene product.

Martín-Castellanos C et al. Prog Cell Cycle Res 1996;2:29-35

PMID:958201 - Genetic control of the cell division cycle in the fission yeast Schizosaccharomyces pombe.

Nurse P et al. Mol Gen Genet 1976 Jul 23;146(2):167-78

PMID:10036242 - Caffeine can override the S-M checkpoint in fission yeast.

Wang SW et al. J Cell Sci 1999 Mar;112 ( Pt 6):927-37

PMID:12618370 - Schizosaccharomyces pombe essential genes: a pilot study.

Decottignies A et al. Genome Res 2003 Mar;13(3):399-406

PMID:33419777 - Identification of mutants with increased variation in cell size at onset of mitosis in fission yeast.

Scotchman E et al. J Cell Sci 2021 Feb 11;134(3)

PMID:1464318 - Pyp3 PTPase acts as a mitotic inducer in fission yeast.

Millar JB et al. EMBO J 1992 Dec;11(13):4933-41

PMID:9436991 - Negative regulation of Cdc18 DNA replication protein by Cdc2.

Lopez-Girona A et al. Mol Biol Cell 1998 Jan;9(1):63-73

PMID:37787465 - Glucose to lactate shift reprograms CDK-dependent mitotic decisions and its communication with MAPK Sty1 in Schizosaccharomyces pombe.

Sarkar P et al. Biol Open 2023 Oct 15;12(10)

PMID:2038306 - Expression of a dominant negative allele of cdc2 prevents activation of the endogenous p34cdc2 kinase.

Fleig UN et al. Mol Gen Genet 1991 May;226(3):432-40

PMID:22182414 - Small heat-shock protein Hsp9 has dual functions in stress adaptation and stress-induced G2-M checkpoint regulation via Cdc25 inactivation in Schizosaccharomyces pombe.

Ahn J et al. Biochem Biophys Res Commun 2012 Jan 06;417(1):613-8

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