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protein coding gene - mtr10 (SPBC11G11.07) - karyopherin/importin-beta family nuclear import receptor Mtr10

Gene summary

Standard name
mtr10
Systematic ID
SPBC11G11.07
Product
karyopherin/importin-beta family nuclear import receptor Mtr10
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
SPBC18H10.01
UniProt ID
Q9USZ2
ORFeome ID
47/47E01
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome II: 1766085..1769138 forward strand

Annotation

Disease association

MONDO:0012034 - autosomal dominant limb-girdle muscular dystrophy type 1F

References:

GO biological process

GO:0051168 - nuclear export

References:

GO:0006606 - protein import into nucleus

References:

GO:0006404 - RNA import into nucleus

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GO cellular component

GO:0005829 - cytosol

References:

GO:0005635 - nuclear envelope

References:

GO:0005634 - nucleus

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GO molecular function

GO:0061608 - nuclear import signal receptor activity

References:

GO:0031267 - small GTPase binding

References:

Protein features

PBO:0111795 - importin family

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000059 - abnormal mitotic cell cycle

References:

Genotypes:

FYPO:0002170 - inviable after spore germination, multiple cell divisions, branched, elongated cell

References:

Genotypes:

FYPO:0000310 - inviable after spore germination, without cell division, with normal germ tube morphology

References:

Genotypes:

FYPO:0002463 - inviable branched, curved, elongated vegetative cell

References:

Genotypes:

FYPO:0002151 - inviable spore

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF03810IBN_NImportin-beta_NPfam
PF08389Xpo1Exportin-1/Importin-b-likePfam
PF24138TPR_TNPO3_IPO13_2ndTPR_TNPO3_IPO13_2ndPfam
PF24139TPR_TNPO3_IPO13_4thTPR_TNPO3_IPO13_4thPfam
PF24140TPR_TNPO3_IPO13_3rdTPR_TNPO3_IPO13_3rdPfam
PS50166IMPORTIN_B_NTImportin-beta_NPROSITE profiles
SM00913IBN_NImportin-beta_NSMART
G3DSA:1.25.10.10:FF:000266CATH-FunFam
G3DSA:1.25.10.10ARM-likeCATH-Gene3D
SSF48371ARM-type_foldSUPERFAMILY
PTHR12363Importin_beta-like_NTRPANTHER

Orthologs

References / Literature

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
GO_REF:0000033 - Annotation inferences using phylogenetic trees
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
GO_REF:0000108 - Automatic assignment of GO terms using logical inference, based on on inter-ontology links.
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:21340088 - Microarray-based target identification using drug hypersensitive fission yeast expressing ORFeome.
Arita Y et al. Mol Biosyst 2011 May;7(5):1463-72
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
GO_REF:0000002 - Comments
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:19336419 - Cotranscriptional recruitment of the nuclear poly(A)-binding protein Pab2 to nascent transcripts and association with translating mRNPs.
Lemieux C et al. Nucleic Acids Res 2009 Jun;37(10):3418-30
PMID:20118936 - Schizosaccharomyces pombe genome-wide nucleosome mapping reveals positioning mechanisms distinct from those of Saccharomyces cerevisiae.
Lantermann AB et al. Nat Struct Mol Biol 2010 Feb;17(2):251-7
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323