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protein coding gene - naa25 (SPBC1215.02c) - NatB N-acetyltransferase complex regulatory subunit Naa25

Gene summary

Standard name
naa25
Systematic ID
SPBC1215.02c
Product
NatB N-acetyltransferase complex regulatory subunit Naa25
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
arm1, mdm20
UniProt ID
Q9Y809
ORFeome ID
47/47F05
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 1506385..1509443 reverse strand

Annotation

GO biological process

GO:1903475 - mitotic actomyosin contractile ring assembly

References:

GO:0051604 - protein maturation

References:

GO cellular component

GO:0005829 - cytosol

References:

GO:0031416 - NatB complex

References:

GO molecular function

GO:0010698 - acetyltransferase activator activity

References:

GO:0003779 - actin binding

References:

GO:0034212 - protein N-acetyltransferase activity

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Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:00047 - O-phospho-L-threonine

References:

MOD:00048 - O4'-phospho-L-tyrosine

References:

Protein features

PBO:0111755 - TPR repeat protein

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000161 - abnormal actomyosin contractile ring assembly

References:

Genotypes:

FYPO:0002393 - abolished protein acetylation during vegetative growth

References:

Genotypes:

FYPO:0003371 - abolished protein localization to actomyosin contractile ring, with protein mislocalized to cytoplasm

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Genotypes:

FYPO:0002027 - angled actomyosin contractile ring

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Genotypes:

FYPO:0002656 - decreased actin filament binding

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Genotypes:

FYPO:0002699 - decreased protein localization to actomyosin contractile ring

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Genotypes:

FYPO:0001365 - decreased rate of actomyosin contractile ring contraction

References:

Genotypes:

FYPO:0001355 - decreased vegetative cell population growth

References:

Genotypes:

FYPO:0001253 - elongated multinucleate multiseptate vegetative cell, single septa between nuclei

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Genotypes:

FYPO:0000650 - increased septation index

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Genotypes:

FYPO:0002170 - inviable after spore germination, multiple cell divisions, branched, elongated cell

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

FYPO:0002657 - normal occurrence of NETO

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Genotypes:

FYPO:0002459 - viable branched, elongated vegetative cell

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF09797NatB_MDM20NAA25_NatB_aux_suPfam
PF31234TPR_Psidin_NPfam
PTHR22767PANTHER

Orthologs

References / Literature

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:20807799 - The recruitment of acetylated and unacetylated tropomyosin to distinct actin polymers permits the discrete regulation of specific myosins in fission yeast.
Coulton AT et al. J Cell Sci 2010 Oct 01;123(Pt 19):3235-43
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.
Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
PMID:23754748 - Splicing functions and global dependency on fission yeast slu7 reveal diversity in spliceosome assembly.
Banerjee S et al. Mol Cell Biol 2013 Aug;33(16):3125-36
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:33496728 - Molecular organization of cytokinesis node predicts the constriction rate of the contractile ring.
Bellingham-Johnstun K et al. J Cell Biol 2021 Mar 01;220(3)
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
GO_REF:0000051 - S. pombe keyword mapping
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7