protein coding gene - ste20 (SPBC12C2.02c) - Rictor homolog, Ste20
Gene summary
- Standard name
- ste20
- Systematic ID
- SPBC12C2.02c
- Product
- Rictor homolog, Ste20
- Organism
- Schizosaccharomyces pombe
(fission yeast)
- Synonyms
- ste16
- UniProt ID
- Q09743
- ORFeome ID
- 34/34A11
- Characterisation status
- biological role published
- Feature type
- mRNA gene
- Genomic location
- chromosome II: 2475879..2480462 forward strand
Annotation
Qualitative gene expression
Quantitative gene expression
Protein features
| ID | Name | InterPro name | DB name |
| PF02185 | HR1 | HR1_rho-bd | Pfam |
| PF14663 | RasGEF_N_2 | Rictor_IV | Pfam |
| PF14664 | RICTOR_N | Pianissimo_N | Pfam |
| PF14666 | RICTOR_M | RICTOR_M | Pfam |
| PF14668 | RICTOR_V | RICTOR_V | Pfam |
| PS51860 | REM_1 | HR1_rho-bd | PROSITE profiles |
| SM00742 | Hr1 | HR1_rho-bd | SMART |
| SM01303 | RasGEF_N_2 | Rictor_IV | SMART |
| SM01307 | RICTOR_M | RICTOR_M | SMART |
| SM01308 | RICTOR_N | Pianissimo_N | SMART |
| SM01310 | RICTOR_V | RICTOR_V | SMART |
| G3DSA:1.10.287.160 | | | CATH-Gene3D |
| G3DSA:1.25.10.10 | | ARM-like | CATH-Gene3D |
| SSF46585 | | HR1_rpt_sf | SUPERFAMILY |
| SSF48371 | | ARM-type_fold | SUPERFAMILY |
| PTHR13298 | | Pianissimo_fam | PANTHER |
| Coil | | | COILS |
| mobidb-lite-Disorder | disorder_prediction | | MobiDB-Disorder |
| mobidb-lite-Polar | disorder_prediction | | MobiDB-Polar |
Orthologs
- RICTOR (HGNC:28611) Homo sapiens
- ste20 (SJAG_04460) Schizosaccharomyces japonicus
- TSC11 (YER093C) Saccharomyces cerevisiae
References / Literature
- PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.
- Lee J et al. Nat Commun 2017 Feb 20;8:14527
- PMID:35820914 - Antagonistic effects of mitochondrial matrix and intermembrane space proteases on yeast aging.
- Vega M et al. BMC Biol 2022 Jul 12;20(1):160
- PMID:15507118 - An interactive gene network for securin-separase, condensin, cohesin, Dis1/Mtc1 and histones constructed by mass transformation.
- Yuasa T et al. Genes Cells 2004 Nov;9(11):1069-82
- PMID:27558664 - Global Fitness Profiling Identifies Arsenic and Cadmium Tolerance Mechanisms in Fission Yeast.
- Guo L et al. G3 (Bethesda) 2016 Oct 13;6(10):3317-3333
- PMID:20144990 - Fission yeast TORC1 regulates phosphorylation of ribosomal S6 proteins in response to nutrients and its activity is inhibited by rapamycin.
- Nakashima A et al. J Cell Sci 2010 Mar 01;123(Pt 5):777-86
- PMID:29632066 - TOR complex 2 in fission yeast is required for chromatin-mediated gene silencing and assembly of heterochromatic domains at subtelomeres.
- Cohen A et al. J Biol Chem 2018 May 25;293(21):8138-8150
- PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
- Rodríguez-López M et al. Elife 2023 Oct 03;12
- PMID:41258116 - TORC2 inactivation promotes heterochromatin formation in rDNA and prolongs viability of quiescent fission yeast cells.
- Hirai H et al. Commun Biol 2025 Nov 19;8(1):1606
- PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
- Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
- PMID:28945192 - Regulated Ire1-dependent mRNA decay requires no-go mRNA degradation to maintain endoplasmic reticulum homeostasis in S. pombe .
- Guydosh NR et al. Elife 2017 Sep 25;6
- PMID:23950735 - Global analysis of fission yeast mating genes reveals new autophagy factors.
- Sun LL et al. PLoS Genet 2013;9(8):e1003715
- PMID:25590601 - Fission yeast Ryh1 GTPase activates TOR Complex 2 in response to glucose.
- Hatano T et al. Cell Cycle 2015;14(6):848-56
- PMID:38971312 - TORC2 is required for accumulation of γH2A in response to DNA damage.
- Cohen A et al. J Biol Chem 2024 Jul 04;:107531
- PMID:23861937 - Genome-wide screening for genes associated with valproic acid sensitivity in fission yeast.
- Zhang L et al. PLoS One 2013;8(7):e68738
- PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.
- Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6
- PMID:21850271 - Genome-wide screening for genes associated with FK506 sensitivity in fission yeast.
- Ma Y et al. PLoS One 2011;6(8):e23422
- PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.
- Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514
- PMID:28264193 - Substrate specificity of TOR complex 2 is determined by a ubiquitin-fold domain of the Sin1 subunit.
- Tatebe H et al. Elife 2017 Mar 07;6
- PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.
- Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
- PMID:22645648 - The reverse, but coordinated, roles of Tor2 (TORC1) and Tor1 (TORC2) kinases for growth, cell cycle and separase-mediated mitosis in Schizosaccharomyces pombe.
- Ikai N et al. Open Biol 2011 Nov;1(3):110007
- PMID:27191590 - Fission Yeast SCYL1/2 Homologue Ppk32: A Novel Regulator of TOR Signalling That Governs Survival during Brefeldin A Induced Stress to Protein Trafficking.
- Kowalczyk KM et al. PLoS Genet 2016 May;12(5):e1006041
- PMID:23703609 - TORC2 is required to maintain genome stability during S phase in fission yeast.
- Schonbrun M et al. J Biol Chem 2013 Jul 05;288(27):19649-60
- PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.
- Halova L et al. Open Biol 2021 Apr;11(4):200405
- PMID:17046992 - Fission yeast Tor2 promotes cell growth and represses cell differentiation.
- Alvarez B et al. J Cell Sci 2006 Nov 01;119(Pt 21):4475-85
- PMID:19417002 - Fission yeast Tor1 functions as part of TORC1 to control mitotic entry through the stress MAPK pathway following nutrient stress.
- Hartmuth S et al. J Cell Sci 2009 Jun 01;122(Pt 11):1737-46
- PMID:24344203 - Isp7 is a novel regulator of amino acid uptake in the TOR signaling pathway.
- Laor D et al. Mol Cell Biol 2014 Mar;34(5):794-806
- PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
- Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
- PMID:24463365 - Systematic screen for mutants resistant to TORC1 inhibition in fission yeast reveals genes involved in cellular ageing and growth.
- Rallis C et al. Biol Open 2014 Feb 15;3(2):161-71
- PMID:18076573 - Rapamycin sensitivity of the Schizosaccharomyces pombe tor2 mutant and organization of two highly phosphorylated TOR complexes by specific and common subunits.
- Hayashi T et al. Genes Cells 2007 Dec;12(12):1357-70
- PMID:8846783 - Fission yeast pak1+ encodes a protein kinase that interacts with Cdc42p and is involved in the control of cell polarity and mating.
- Ottilie S et al. EMBO J 1995 Dec 01;14(23):5908-19
- PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
- Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
- PMID:21035342 - Rab-family GTPase regulates TOR complex 2 signaling in fission yeast.
- Tatebe H et al. Curr Biol 2010 Nov 23;20(22):1975-82
- PMID:21760946 - Identification of genes affecting the toxicity of anti-cancer drug bortezomib by genome-wide screening in S. pombe.
- Takeda K et al. PLoS One 2011;6(7):e22021
- PMID:25411338 - Mechanisms of expression and translocation of major fission yeast glucose transporters regulated by CaMKK/phosphatases, nuclear shuttling, and TOR.
- Saitoh S et al. Mol Biol Cell 2015 Jan 15;26(2):373-86
- PMID:26152587 - TORC1 Regulates Developmental Responses to Nitrogen Stress via Regulation of the GATA Transcription Factor Gaf1.
- Laor D et al. mBio 2015 Jul 07;6(4):e00959
- PMID:27206859 - TOR complex 2 localises to the cytokinetic actomyosin ring and controls the fidelity of cytokinesis.
- Baker K et al. J Cell Sci 2016 Jul 01;129(13):2613-24
- PMID:31477575 - Modulation of TOR complex 2 signaling by the stress-activated MAPK pathway in fission yeast.
- Morigasaki S et al. J Cell Sci 2019 Oct 10;132(19)
- PMID:21511999 - Comparative functional genomics of the fission yeasts.
- Rhind N et al. Science 2011 May 20;332(6032):930-6
- PMID:19546237 - TOR complex 2 controls gene silencing, telomere length maintenance, and survival under DNA-damaging conditions.
- Schonbrun M et al. Mol Cell Biol 2009 Aug;29(16):4584-94
- GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
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- PMID:17261596 - Loss of the TOR kinase Tor2 mimics nitrogen starvation and activates the sexual development pathway in fission yeast.
- Matsuo T et al. Mol Cell Biol 2007 Apr;27(8):3154-64
- PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
- Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
- PMID:20537132 - Global fitness profiling of fission yeast deletion strains by barcode sequencing.
- Han TX et al. Genome Biol 2010;11(6):R60
- PMID:18235227 - Fission yeast TOR complex 2 activates the AGC-family Gad8 kinase essential for stress resistance and cell cycle control.
- Ikeda K et al. Cell Cycle 2008 Feb 01;7(3):358-64
- PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
- Hayles J et al. Open Biol 2013 May 22;3(5):130053
- PMID:19264558 - Screening a genome-wide S. pombe deletion library identifies novel genes and pathways involved in genome stability maintenance.
- Deshpande GP et al. DNA Repair (Amst) 2009 May 01;8(5):672-9
- PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
- Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
- PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
- Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
- PMID:26098123 - Promoter nucleosome dynamics regulated by signalling through the CTD code.
- Materne P et al. Elife 2015 Jun 22;4:e09008
- PMID:28281664 - Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes.
- Rallis C et al. Sci Rep 2017 Mar 10;7:44257
- PMID:10467002 - Gene ste20 controls amiloride sensitivity and fertility in Schizosaccharomyces pombe.
- Hilti N et al. Curr Genet 1999 Jul;35(6):585-92
- PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
- Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
