protein coding gene - dnm1 (SPBC12C2.08) - mitochondrial dynamin family scission GTPase Dnm1

Gene summary

Standard name

dnm1

Systematic ID

SPBC12C2.08

Product

mitochondrial dynamin family scission GTPase Dnm1

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

Q09748

ORFeome ID

28/28H09

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome II: 2458816..2461696 reverse strand

Annotation

Protein features

Orthologs

• DNM1 (HGNC:2972) Homo sapiens
• DNM1L (HGNC:2973) Homo sapiens
• dnm1 (SJAG_02848) Schizosaccharomyces japonicus
• DNM1 (YLL001W) Saccharomyces cerevisiae

References / Literature

PMID:30649994 - A conserved mechanism for mitochondria-dependent dynein anchoring.

Kraft LM et al. Mol Biol Cell 2019 Mar 01;30(5):691-702

PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41

PMID:18818364 - Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast.

Roguev A et al. Science 2008 Oct 17;322(5900):405-10

PMID:25262651 - De novo mutations in synaptic transmission genes including DNM1 cause epileptic encephalopathies.

EuroEPINOMICS-RES Consortium et al. Am J Hum Genet 2014 Oct 02;95(4):360-70

PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Lee J et al. Nat Commun 2017 Feb 20;8:14527

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

PMID:20587778 - Quantitative analysis of the mechanism of endocytic actin patch assembly and disassembly in fission yeast.

Sirotkin V et al. Mol Biol Cell 2010 Aug 15;21(16):2894-904

PMID:18088324 - Dynamin-dependent biogenesis, cell cycle regulation and mitochondrial association of peroxisomes in fission yeast.

Jourdain I et al. Traffic 2008 Mar;9(3):353-65

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:31562247 - Glucose starvation induces mitochondrial fragmentation depending on the dynamin GTPase Dnm1/Drp1 in fission yeast.

Zheng F et al. J Biol Chem 2019 Nov 22;294(47):17725-17734

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:30602572 - Association of mitochondria with microtubules inhibits mitochondrial fission by precluding assembly of the fission protein Dnm1.

Mehta K et al. J Biol Chem 2019 Mar 08;294(10):3385-3396

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:39379376 - Ribosomes hibernate on mitochondria during cellular stress.

Gemin O et al. Nat Commun 2024 Oct 08;15(1):8666

PMID:37590302 - The AAA-ATPase Yta4/ATAD1 interacts with the mitochondrial divisome to inhibit mitochondrial fission.

He J et al. PLoS Biol 2023 Aug;21(8):e3002247

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:27664110 - Loss of Msp1p in Schizosaccharomyces pombe induces a ROS-dependent nuclear mutator phenotype that affects mitochondrial fission genes.

Delerue T et al. FEBS Lett 2016 Oct;590(20):3544-3558

PMID:28515144 - Transient activation of fission yeast AMPK is required for cell proliferation during osmotic stress.

Schutt KL et al. Mol Biol Cell 2017 Jul 01;28(13):1804-1814

PMID:35658118 - The acyl-CoA-binding protein Acb1 regulates mitochondria, lipid droplets, and cell proliferation.

He J et al. FEBS Lett 2022 Jul;596(14):1795-1808

PMID:20070859 - Fission yeast Vps1 and Atg8 contribute to oxidative stress resistance.

Mikawa T et al. Genes Cells 2010 Mar;15(3):229-42

PMID:19643199 - The dynamin-related protein Vps1 regulates vacuole fission, fusion and tubulation in the fission yeast, Schizosaccharomyces pombe.

Röthlisberger S et al. Fungal Genet Biol 2009 Dec;46(12):927-35

PMID:22119525 - SIN-inhibitory phosphatase complex promotes Cdc11p dephosphorylation and propagates SIN asymmetry in fission yeast.

Singh NS et al. Curr Biol 2011 Dec 06;21(23):1968-78

PMID:36633091 - Microtubule-mitochondrial attachment facilitates cell division symmetry and mitochondrial partitioning in fission yeast.

Chacko LA et al. J Cell Sci 2023 Jan 01;136(1)

PMID:25076038 - Large scale screening of genetic interaction with sgf73(+) in fission yeast.

Guo Y et al. Yi Chuan 2014 Jul;36(7):723-31

PMID:23521895 - Chemical genetic screen in fission yeast reveals roles for vacuolar acidification, mitochondrial fission, and cellular GMP levels in lifespan extension.

Stephan J et al. Aging Cell 2013 Aug;12(4):574-83

PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.

Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323

GO_REF:0000002 - Comments

PMID:22540037 - Predicting the fission yeast protein interaction network.

Pancaldi V et al. G3 (Bethesda) 2012 Apr;2(4):453-67

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:26644575 - Discovery of a nucleocytoplasmic O-mannose glycoproteome in yeast.

Halim A et al. Proc Natl Acad Sci U S A 2015 Dec 22;112(51):15648-53

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.

Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160

GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.

PMID:34310050 - Mitochondrial fusion and fission are required for proper mitochondrial function and cell proliferation in fission yeast.

Dong F et al. FEBS J 2022 Jan;289(1):262-278

PMID:19373772 - The dynamin related protein Dnm1 fragments mitochondria in a microtubule-dependent manner during the fission yeast cell cycle.

Jourdain I et al. Cell Motil Cytoskeleton 2009 Aug;66(8):509-23

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:15710398 - Msp1p is an intermembrane space dynamin-related protein that mediates mitochondrial fusion in a Dnm1p-dependent manner in S. pombe.

Guillou E et al. FEBS Lett 2005 Feb 14;579(5):1109-16

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:21760946 - Identification of genes affecting the toxicity of anti-cancer drug bortezomib by genome-wide screening in S. pombe.

Takeda K et al. PLoS One 2011;6(7):e22021

PMID:30658998 - A yeast-based screening assay identifies repurposed drugs that suppress mitochondrial fusion and mtDNA maintenance defects.

Delerue T et al. Dis Model Mech 2019 Feb 07;12(2)

PMID:33125774 - dnm1 deletion blocks mitochondrial fragmentation in Δfzo1 cells.

Yang Y et al. Yeast 2021 Mar;38(3):197-205

PMID:35820914 - Antagonistic effects of mitochondrial matrix and intermembrane space proteases on yeast aging.

Vega M et al. BMC Biol 2022 Jul 12;20(1):160

PMID:37540145 - Completion of mitochondrial division requires the intermembrane space protein Mdi1/Atg44.

Connor OM et al. J Cell Biol 2023 Oct 02;222(10)

PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.

Strachan J et al. J Cell Sci 2023 Dec 01;136(23)

PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.

Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963