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protein coding gene - pck2 (SPBC12D12.04c) - protein kinase C (PKC)-like Pck2

Gene summary

Standard name
pck2
Systematic ID
SPBC12D12.04c
Product
protein kinase C (PKC)-like Pck2
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
sts6, pkc1, mok3
UniProt ID
P36583
ORFeome ID
34/34A04
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 2309126..2313008 reverse strand

Annotation

PBO:0000508 - 2.7.1.-

Disease association

MONDO:8000024 - autoimmune lymphoproliferative syndrome, type III caused by mutation in PRKCD

References:

GO biological process

GO:0009272 - fungal-type cell wall biogenesis

References:

GO:1902660 - negative regulation of glucose mediated signaling pathway

References:

GO:1903139 - positive regulation of cell integrity MAPK cascade

References:

GO:0090334 - regulation of cell wall (1->3)-beta-D-glucan biosynthetic process

References:

GO:2000769 - regulation of establishment or maintenance of cell polarity regulating cell shape

References:

GO:0070610 - regulation of fungal-type cell wall (1->3)-alpha-glucan biosynthetic process

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GO cellular component

GO:0005938 - cell cortex

References:

GO:0032153 - cell division site

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GO:0051286 - cell tip

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GO:0000935 - division septum

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GO molecular function

GO:0004697 - diacylglycerol-dependent serine/threonine kinase activity

References:

GO:0008289 - lipid binding

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GO:0005515 - protein binding

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Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:00047 - O-phospho-L-threonine

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MOD:00048 - O4'-phospho-L-tyrosine

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MOD:00696 - phosphorylated residue

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Multi-locus phenotype

FYPO:0006709 - abolished protein phosphorylation during cellular response to salt stress

References:

Genotypes:

FYPO:0000046 - decreased cell population growth

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Genotypes:

FYPO:0001235 - decreased extent of cell population growth

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Genotypes:

FYPO:0002679 - decreased protein phosphorylation

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Genotypes:

FYPO:0001838 - decreased protein phosphorylation during vegetative growth

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Genotypes:

FYPO:0001355 - decreased vegetative cell population growth

References:

Genotypes:

FYPO:0001309 - increased viability in stationary phase

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Genotypes:

FYPO:0002151 - inviable spore

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

FYPO:0007293 - lysed spherical vegetative cell

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Genotypes:

FYPO:0000118 - multiseptate vegetative cell

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Genotypes:

FYPO:0001037 - normal growth during cellular response to salt stress

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Genotypes:

FYPO:0001883 - normal growth on caspofungin

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Genotypes:

FYPO:0003075 - normal protein kinase activity

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Genotypes:

FYPO:0000776 - normal protein phosphorylation during vegetative growth

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Genotypes:

FYPO:0001310 - normal viability in stationary phase

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Genotypes:

FYPO:0007359 - resistance to heavy water

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Genotypes:

FYPO:0002720 - sensitive to beta-glucanase

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Genotypes:

FYPO:0000105 - sensitive to cyclosporin A

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Genotypes:

FYPO:0002526 - sensitive to latrunculin B

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Genotypes:

FYPO:0005889 - sensitive to sodium chloride

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Genotypes:

FYPO:0000112 - sensitive to sorbitol

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Genotypes:

FYPO:0007522 - sensitive to tacrolimus and magnesium chloride

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Genotypes:

FYPO:0002459 - viable branched, elongated vegetative cell

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Genotypes:

FYPO:0003481 - viable elongated vegetative cell, elongated upon mitotic entry

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

Protein features

PBO:0111863 - C1 domain

PBO:0111864 - C2 domain

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0001971 - abnormal cell separation after cytokinesis resulting in chained cells

References:

Genotypes:

FYPO:0000174 - abnormal cell wall biogenesis

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Genotypes:

FYPO:0000026 - abnormal vegetative cell polarity

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Genotypes:

FYPO:0001179 - abolished protein localization during vegetative growth

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Genotypes:

FYPO:0000705 - abolished protein-protein interaction

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Genotypes:

FYPO:0003535 - decreased bipolar index

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Genotypes:

FYPO:0000082 - decreased cell population growth at high temperature

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Genotypes:

FYPO:0000080 - decreased cell population growth at low temperature

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Genotypes:

FYPO:0000251 - decreased cell population growth on galactose carbon source

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Genotypes:

FYPO:0001407 - decreased cell population growth on glucose carbon source

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Genotypes:

FYPO:0009091 - decreased cell population growth on lysine and proline nitrogen source

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Genotypes:

FYPO:0002924 - decreased cell population growth on maltose carbon source

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Genotypes:

FYPO:0009099 - decreased cell population growth on mannitol carbon source

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Genotypes:

FYPO:0001081 - decreased cell wall alpha-glucan level

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Genotypes:

FYPO:0002163 - decreased cell wall thickness during vegetative growth

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Genotypes:

FYPO:0006978 - decreased cellular coenzyme Q10 level

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Genotypes:

FYPO:0002679 - decreased protein phosphorylation

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Genotypes:

FYPO:0001838 - decreased protein phosphorylation during vegetative growth

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Genotypes:

FYPO:0001645 - decreased protein-protein interaction

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Genotypes:

FYPO:0004480 - decreased transcription from CDRE promoter in response to micafungin

References:

Genotypes:

FYPO:0004479 - decreased transcription from CDRE promoter in response to salt stress

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Genotypes:

FYPO:0000223 - elongated multiseptate vegetative cell

References:

Genotypes:

FYPO:0001968 - increased 1,3-beta-D-glucan synthase activity

References:

Genotypes:

FYPO:0001194 - increased beta-glucan level

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Genotypes:

FYPO:0009028 - increased cell population growth on proline nitrogen source

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Genotypes:

FYPO:0001084 - increased cell wall alpha-glucan level

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Genotypes:

FYPO:0001035 - increased cell wall thickness during vegetative growth

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Genotypes:

FYPO:0001198 - increased cellular calcium level

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Genotypes:

FYPO:0003532 - increased monopolar index

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Genotypes:

FYPO:0005197 - increased protein phosphorylation during glucose starvation

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Genotypes:

FYPO:0001038 - increased protein phosphorylation during vegetative growth

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Genotypes:

FYPO:0002462 - inviable branched, elongated vegetative cell

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Genotypes:

FYPO:0001489 - inviable vegetative cell

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

FYPO:0002630 - irregular cell wall during vegetative growth

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Genotypes:

FYPO:0000245 - loss of viability in stationary phase

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Genotypes:

FYPO:0000118 - multiseptate vegetative cell

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Genotypes:

FYPO:0002157 - normal 1,3-beta-D-glucan synthase activity

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Genotypes:

FYPO:0001079 - normal galactomannan level

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Genotypes:

FYPO:0001037 - normal growth during cellular response to salt stress

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Genotypes:

FYPO:0001020 - normal growth on calcium

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Genotypes:

FYPO:0002161 - normal growth on Calcofluor White

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Genotypes:

FYPO:0001192 - normal growth on cell wall-degrading enzymes

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Genotypes:

FYPO:0002160 - normal growth on cilofungin

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Genotypes:

FYPO:0001164 - normal growth on glucose carbon source

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Genotypes:

FYPO:0003706 - normal growth on K-252a

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Genotypes:

FYPO:0000961 - normal growth on sorbitol

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Genotypes:

FYPO:0000776 - normal protein phosphorylation during vegetative growth

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Genotypes:

FYPO:0000703 - normal protein-protein interaction

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Genotypes:

FYPO:0001315 - normal vegetative cell morphology

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Genotypes:

FYPO:0001357 - normal vegetative cell population growth

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Genotypes:

FYPO:0001420 - normal vegetative cell population growth rate

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Genotypes:

FYPO:0009030 - resistance to amitrole

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Genotypes:

FYPO:0000067 - resistance to brefeldin A

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Genotypes:

FYPO:0000763 - resistance to cadmium

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Genotypes:

FYPO:0002162 - resistance to cilofungin

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Genotypes:

FYPO:0000764 - resistance to cycloheximide

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Genotypes:

FYPO:0009038 - resistance to egtazic acid

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Genotypes:

FYPO:0007359 - resistance to heavy water

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Genotypes:

FYPO:0001583 - resistance to lithium

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Genotypes:

FYPO:0009085 - resistance to lithium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0005969 - resistance to magnesium chloride

References:

Genotypes:

FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0000725 - resistance to methyl methanesulfonate

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Genotypes:

FYPO:0000767 - resistance to staurosporine

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Genotypes:

FYPO:0007521 - resistance to tacrolimus and magnesium chloride

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Genotypes:

FYPO:0001966 - sensitive to aculeacin A

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Genotypes:

FYPO:0009067 - sensitive to amorolfine

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Genotypes:

FYPO:0000094 - sensitive to benomyl

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Genotypes:

FYPO:0002720 - sensitive to beta-glucanase

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Genotypes:

FYPO:0000097 - sensitive to caffeine during vegetative growth

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Genotypes:

FYPO:0003840 - sensitive to carbendazim

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Genotypes:

FYPO:0000079 - sensitive to caspofungin

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Genotypes:

FYPO:0000104 - sensitive to cycloheximide

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Genotypes:

FYPO:0000105 - sensitive to cyclosporin A

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Genotypes:

FYPO:0000842 - sensitive to ethanol during vegetative growth

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Genotypes:

FYPO:0000785 - sensitive to formamide

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Genotypes:

FYPO:0000087 - sensitive to hydrogen peroxide

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Genotypes:

FYPO:0000088 - sensitive to hydroxyurea

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Genotypes:

FYPO:0000107 - sensitive to latrunculin A

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Genotypes:

FYPO:0002526 - sensitive to latrunculin B

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Genotypes:

FYPO:0000109 - sensitive to papulacandin B

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Genotypes:

FYPO:0001214 - sensitive to potassium chloride

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Genotypes:

FYPO:0007924 - sensitive to potassium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0000111 - sensitive to rapamycin

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Genotypes:

FYPO:0000271 - sensitive to salt stress

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Genotypes:

FYPO:0005889 - sensitive to sodium chloride

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Genotypes:

FYPO:0000841 - sensitive to sodium dodecyl sulfate

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Genotypes:

FYPO:0000112 - sensitive to sorbitol

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Genotypes:

FYPO:0000113 - sensitive to staurosporine

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Genotypes:

FYPO:0000091 - sensitive to thiabendazole

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Genotypes:

FYPO:0002701 - sensitive to torin1

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Genotypes:

FYPO:0001457 - sensitive to tunicamycin

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Genotypes:

FYPO:0003656 - sensitive to vanadate

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Genotypes:

FYPO:0009064 - sensitive to X-rays and rapamycin during vegetative growth.

References:

Genotypes:

FYPO:0000647 - vegetative cell lysis

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Genotypes:

FYPO:0002903 - viable pear-shaped vegetative cell

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Genotypes:

FYPO:0000648 - viable small vegetative cell

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Genotypes:

FYPO:0002380 - viable spheroid vegetative cell

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Genotypes:

FYPO:0002106 - viable stubby vegetative cell

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Genotypes:

FYPO:0001491 - viable vegetative cell

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

Protein features

IDNameInterPro nameDB name
PF00069PkinaseProt_kinase_domPfam
PF00130C1_1PKC_DAG/PEPfam
PF00433Pkinase_CPkinase_CPfam
PF02185HR1HR1_rho-bdPfam
cd05570STKc_PKCCDD
cd08689C2_fungal_Pkc1pC2_fungal_PKCCDD
cd11620HR1_PKC-like_2_fungiPKC-like_HR1CDD
cd11621HR1_PKC-like_1_fungiCDD
cd20822C1_ScPKC1-like_rpt1CDD
cd20823C1_ScPKC1-like_rpt2CDD
PS00107PROTEIN_KINASE_ATPProtein_kinase_ATP_BSPROSITE patterns
PS00108PROTEIN_KINASE_STSer/Thr_kinase_ASPROSITE patterns
PS00479ZF_DAG_PE_1PKC_DAG/PEPROSITE patterns
PS50004C2C2_domPROSITE profiles
PS50011PROTEIN_KINASE_DOMProt_kinase_domPROSITE profiles
PS50081ZF_DAG_PE_2PKC_DAG/PEPROSITE profiles
PS51285AGC_KINASE_CTERAGC-kinase_CPROSITE profiles
PS51860REM_1HR1_rho-bdPROSITE profiles
SM00109C1PKC_DAG/PESMART
SM00133S_TK_XAGC-kinase_CSMART
SM00220S_TKcProt_kinase_domSMART
SM00239C2C2_domSMART
SM00742Hr1HR1_rho-bdSMART
G3DSA:1.10.287.160:FF:000004CATH-FunFam
G3DSA:1.10.510.10:FF:000101CATH-FunFam
G3DSA:3.30.200.20:FF:000103CATH-FunFam
G3DSA:3.30.60.20:FF:000014CATH-FunFam
G3DSA:3.30.60.20:FF:000034CATH-FunFam
G3DSA:1.10.287.160CATH-Gene3D
G3DSA:1.10.510.10CATH-Gene3D
G3DSA:3.30.200.20CATH-Gene3D
G3DSA:3.30.60.20CATH-Gene3D
SSF46585HR1_rpt_sfSUPERFAMILY
SSF49562C2_domain_sfSUPERFAMILY
SSF56112Kinase-like_dom_sfSUPERFAMILY
SSF57889C1-like_sfSUPERFAMILY
PTHR24351PANTHER
CoilCOILS
mobidb-lite-Disorderdisorder_predictionMobiDB-Disorder
mobidb-lite-Low-complexitydisorder_predictionMobiDB-Low-complexity
mobidb-lite-Positive-Polyelectrolytedisorder_predictionMobiDB-Positive-Polyelectrolyte

Orthologs

References / Literature

PMID:27168121 - Discovery of genes involved in mitosis, cell division, cell wall integrity and chromosome segregation through construction of Schizosaccharomyces pombe deletion strains.
Chen JS et al. Yeast 2016 Sep;33(9):507-17
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.
Halova L et al. Open Biol 2021 Apr;11(4):200405
PMID:9427748 - pmp1+, a suppressor of calcineurin deficiency, encodes a novel MAP kinase phosphatase in fission yeast.
Sugiura R et al. EMBO J 1998 Jan 02;17(1):140-8
PMID:20501954 - Search for kinases related to transition of growth polarity in fission yeast.
Koyano T et al. Biosci Biotechnol Biochem 2010;74(5):1129-33
PMID:11263963 - Rkp1/Cpc2, a fission yeast RACK1 homolog, is involved in actin cytoskeleton organization through protein kinase C, Pck2, signaling.
Won M et al. Biochem Biophys Res Commun 2001 Mar 23;282(1):10-5
PMID:23907979 - The fission yeast cell wall stress sensor-like proteins Mtl2 and Wsc1 act by turning on the GTPase Rho1p but act independently of the cell wall integrity pathway.
Cruz S et al. Microbiologyopen 2013 Oct;2(5):778-94
PMID:9135147 - Spm1, a stress-activated MAP kinase that regulates morphogenesis in S.pombe.
Zaitsevskaya-Carter T et al. EMBO J 1997 Mar 17;16(6):1318-31
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:25651781 - Geranylgeranyltransferase Cwg2-Rho4/Rho5 module is implicated in the Pmk1 MAP kinase-mediated cell wall integrity pathway in fission yeast.
Doi A et al. Genes Cells 2015 Apr;20(4):310-23
PMID:24498240 - Rho1 GTPase and PKC ortholog Pck1 are upstream activators of the cell integrity MAPK pathway in fission yeast.
Sánchez-Mir L et al. PLoS One 2014;9(1):e88020
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:34198697 - Specific Functional Features of the Cell Integrity MAP Kinase Pathway in the Dimorphic Fission Yeast Schizosaccharomyces japonicus .
Gómez-Gil E et al. J Fungi (Basel) 2021 Jun 14;7(6)
PMID:9405296 - Genes that cause aberrant cell morphology by overexpression in fission yeast: a role of a small GTP-binding protein Rho2 in cell morphogenesis.
Hirata D et al. J Cell Sci 1998 Jan;111 ( Pt 2):149-59
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.
Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160
PMID:1899230 - Fission yeast genes that confer resistance to staurosporine encode an AP-1-like transcription factor and a protein kinase related to the mammalian ERK1/MAP2 and budding yeast FUS3 and KSS1 kinases.
Toda T et al. Genes Dev 1991 Jan;5(1):60-73
PMID:7929623 - Fission yeast protein kinase C gene homologues are required for protoplast regeneration: a functional link between cell wall formation and cell shape control.
Kobori H et al. J Cell Sci 1994 May;107 ( Pt 5):1131-6
PMID:16224022 - Counting cytokinesis proteins globally and locally in fission yeast.
Wu JQ et al. Science 2005 Oct 14;310(5746):310-4
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:16928959 - Real-time monitoring of calcineurin activity in living cells: evidence for two distinct Ca2+-dependent pathways in fission yeast.
Deng L et al. Mol Biol Cell 2006 Nov;17(11):4790-800
PMID:8491190 - Two novel protein kinase C-related genes of fission yeast are essential for cell viability and implicated in cell shape control.
Toda T et al. EMBO J 1993 May;12(5):1987-95
PMID:8463273 - A Ca(2+)-independent protein kinase C from fission yeast.
Mazzei GJ et al. J Biol Chem 1993 Apr 05;268(10):7401-6
PMID:17005909 - Rho2 is a target of the farnesyltransferase Cpp1 and acts upstream of Pmk1 mitogen-activated protein kinase signaling in fission yeast.
Ma Y et al. Mol Biol Cell 2006 Dec;17(12):5028-37
PMID:37792890 - Elevated levels of sphingolipid MIPC in the plasma membrane disrupt the coordination of cell growth with cell wall formation in fission yeast.
Willet AH et al. PLoS Genet 2023 Oct;19(10):e1010987
PMID:8943330 - The fission yeast pmk1+ gene encodes a novel mitogen-activated protein kinase homolog which regulates cell integrity and functions coordinately with the protein kinase C pathway.
Toda T et al. Mol Cell Biol 1996 Dec;16(12):6752-64
PMID:15821139 - Systematic deletion analysis of fission yeast protein kinases.
Bimbó A et al. Eukaryot Cell 2005 Apr;4(4):799-813
PMID:30044717 - Roles of the fission yeast UNC-13/Munc13 protein Ync13 in late stages of cytokinesis.
Zhu YH et al. Mol Biol Cell 2018 Sep 15;29(19):2259-2279
PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.
Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514
PMID:32142608 - Mutations in a Single Signaling Pathway Allow Cell Growth in Heavy Water.
Kampmeyer C et al. ACS Synth Biol 2020 Apr 17;9(4):733-748
PMID:10651902 - Rho-dependence of Schizosaccharomyces pombe Pck2.
Sayers LG et al. Genes Cells 2000 Jan;5(1):17-27
PMID:11016847 - Schizosaccharomyces pombe ehs1p is involved in maintaining cell wall integrity and in calcium uptake.
Carnero E et al. Mol Gen Genet 2000 Sep;264(1-2):173-83
PMID:15923187 - Phosphatidylinositol-4-phosphate 5-kinase regulates fission yeast cell integrity through a phospholipase C-mediated protein kinase C-independent pathway.
Deng L et al. J Biol Chem 2005 Jul 29;280(30):27561-8
PMID:18257517 - Phosphoproteome analysis of fission yeast.
Wilson-Grady JT et al. J Proteome Res 2008 Mar;7(3):1088-97
PMID:14625898 - Ksg1, a homologue of the phosphoinositide-dependent protein kinase 1, controls cell wall integrity in Schizosaccharomyces pombe.
Gräub R et al. J Basic Microbiol 2003;43(6):473-82
PMID:18793338 - Rga2 is a Rho2 GAP that regulates morphogenesis and cell integrity in S. pombe.
Villar-Tajadura MA et al. Mol Microbiol 2008 Nov;70(4):867-81
PMID:23294323 - The Kin1 kinase and the calcineurin phosphatase cooperate to link actin ring assembly and septum synthesis in fission yeast.
Cadou A et al. Biol Cell 2013 Mar;105(3):129-48
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:19625445 - Role for RACK1 orthologue Cpc2 in the modulation of stress response in fission yeast.
Núñez A et al. Mol Biol Cell 2009 Sep;20(18):3996-4009
PMID:39540318 - Pck2 association with the plasma membrane and efficient response of the cell integrity pathway require regulation of PI4P homeostasis by exomer.
Moscoso-Romero E et al. Open Biol 2024 Nov;14(11):240101
PMID:32062975 - Phosphoproteomics Reveals Novel Targets and Phosphoprotein Networks in Cell Cycle Mediated by Dsk1 Kinase.
Wu M et al. J Proteome Res 2020 Apr 03;19(4):1776-1787
PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.
Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:9203581 - Fission yeast WD-repeat protein pop1 regulates genome ploidy through ubiquitin-proteasome-mediated degradation of the CDK inhibitor Rum1 and the S-phase initiator Cdc18.
Kominami K et al. Genes Dev 1997 Jun 15;11(12):1548-60
PMID:10504305 - Schizosaccharomyces pombe protein kinase C homologues, pck1p and pck2p, are targets of rho1p and rho2p and differentially regulate cell integrity.
Arellano M et al. J Cell Sci 1999 Oct;112 ( Pt 20):3569-78
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:19547744 - Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.
Beltrao P et al. PLoS Biol 2009 Jun 16;7(6):e1000134
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:16421249 - Rgf1p is a specific Rho1-GEF that coordinates cell polarization with cell wall biogenesis in fission yeast.
García P et al. Mol Biol Cell 2006 Apr;17(4):1620-31
PMID:24928510 - Glucose activates TORC2-Gad8 protein via positive regulation of the cAMP/cAMP-dependent protein kinase A (PKA) pathway and negative regulation of the Pmk1 protein-mitogen-activated protein kinase pathway.
Cohen A et al. J Biol Chem 2014 Aug 01;289(31):21727-37
PMID:20624220 - Kin1 is a plasma membrane-associated kinase that regulates the cell surface in fission yeast.
Cadou A et al. Mol Microbiol 2010 Sep;77(5):1186-202
PMID:19486165 - Pleiotropic phenotypes caused by an opal nonsense mutation in an essential gene encoding HMG-CoA reductase in fission yeast.
Fang Y et al. Genes Cells 2009 Jun;14(6):759-71
PMID:20164182 - Rga4 modulates the activity of the fission yeast cell integrity MAPK pathway by acting as a Rho2 GTPase-activating protein.
Soto T et al. J Biol Chem 2010 Apr 09;285(15):11516-25
PMID:27298342 - Identification of S-phase DNA damage-response targets in fission yeast reveals conservation of damage-response networks.
Willis NA et al. Proc Natl Acad Sci U S A 2016 Jun 28;113(26):E3676-85
PMID:28264193 - Substrate specificity of TOR complex 2 is determined by a ubiquitin-fold domain of the Sin1 subunit.
Tatebe H et al. Elife 2017 Mar 07;6
PMID:20739711 - Cooperation between the septins and the actomyosin ring and role of a cell-integrity pathway during cell division in fission yeast.
Wu JQ et al. Genetics 2010 Nov;186(3):897-915
PMID:11102532 - Schizosaccharomyces pombe rho2p GTPase regulates cell wall alpha-glucan biosynthesis through the protein kinase pck2p.
Calonge TM et al. Mol Biol Cell 2000 Dec;11(12):4393-401
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:28536259 - Differential functional regulation of protein kinase C (PKC) orthologs in fission yeast.
Madrid M et al. J Biol Chem 2017 Jul 07;292(27):11374-11387
PMID:29689193 - Mechanosensation Dynamically Coordinates Polar Growth and Cell Wall Assembly to Promote Cell Survival.
Davì V et al. Dev Cell 2018 Apr 23;45(2):170-182.e7
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:31030285 - CoQ 10 production in Schizosaccharomyces pombe is increased by reduction of glucose levels or deletion of pka1.
Nishida I et al. Appl Microbiol Biotechnol 2019 Jun;103(12):4899-4915
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