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protein coding gene - mrm1 (SPBC1347.13c) - mitochondrial rRNA ribose methyltransferase Mrm1

Gene summary

Standard name
mrm1
Systematic ID
SPBC1347.13c
Product
mitochondrial rRNA ribose methyltransferase Mrm1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O94631
ORFeome ID
17/17A07
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome II: 4085349..4086593 reverse strand

Annotation

GO biological process

GO:1902775 - mitochondrial large ribosomal subunit assembly

References:

GO:0000963 - mitochondrial RNA processing

References:

GO:0031167 - rRNA methylation

References:

GO cellular component

GO:0005759 - mitochondrial matrix

References:

GO molecular function

GO:0062105 - RNA 2'-O-methyltransferase activity

References:

GO:0003723 - RNA binding

References:

GO:0008989 - rRNA (guanine-N1-)-methyltransferase activity

References:

Protein sequence feature

SO:0001808 - mitochondrial_targeting_signal

References:

Qualitative gene expression

PomGeneEx:0000012 - RNA level decreased

References:

Quantitative gene expression

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000121 - abnormal sporulation

References:

Genotypes:

FYPO:0009072 - increased cell population growth on lysine nitrogen source

References:

Genotypes:

FYPO:0009038 - resistance to egtazic acid

References:

Genotypes:

FYPO:0009035 - resistance to formamide

References:

Genotypes:

FYPO:0001583 - resistance to lithium

References:

Genotypes:

FYPO:0009083 - resistance to lithium chloride and methyl methanesulfonate

References:

Genotypes:

FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0001234 - slow vegetative cell population growth

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF08032SpoU_sub_bindSpoU_subst-bdPFAM
PF00588SpoU_methylaseSpoU_MeTrfasePFAM
cd18105SpoU-like_MRM1MRM1_MeTrfase_domCDD
SM00967SpoU_sub_bind_2SpoU_subst-bdSMART
G3DSA:3.40.1280.10:FF:000094FUNFAM
SSF55315L30e-likeRibosomal_eL30-like_sfSUPERFAMILY
SSF75217alpha/beta knotAlpha/beta_knot_MTasesSUPERFAMILY
G3DSA:3.30.1330.30Ribosomal_eL30-like_sfGENE3D
G3DSA:3.40.1280.10tRNA_m1G_MTases_NGENE3D
PTHR46103RRNA METHYLTRANSFERASE 1, MITOCHONDRIALMRM1PANTHER
mobidb-lite-Disorderdisorder_predictionMOBIDB-Disorder
TIGR00186rRNA_methyl_3rRNA_MeTrfase_TrmHNCBIFAM

Orthologs

References / Literature

PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
GO_REF:0000002 - Comments
GO_REF:0000116 - Automatic Gene Ontology annotation based on Rhea mapping.
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:24036117 - Mitochondrial ribosomal RNA (rRNA) methyltransferase family members are positioned to modify nascent rRNA in foci near the mitochondrial DNA nucleoid.
Lee KW et al. J Biol Chem 2013 Oct 25;288(43):31386-99
PMID:25452419 - Parallel profiling of fission yeast deletion mutants for proliferation and for lifespan during long-term quiescence.
Sideri T et al. G3 (Bethesda) 2014 Dec 01;5(1):145-55
PMID:36478272 - Translation-complex profiling of fission yeast cells reveals dynamic rearrangements of scanning ribosomal subunits upon nutritional stress.
Duncan CDS et al. Nucleic Acids Res 2022 Dec 09;50(22):13011-13025
PMID:34339868 - The roles of assembly factors in mammalian mitoribosome biogenesis.
Hilander T et al. Mitochondrion 2021 Sep;60:70-84
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:29259000 - Genes Important for Schizosaccharomyces pombe Meiosis Identified Through a Functional Genomics Screen.
Blyth J et al. Genetics 2018 Feb;208(2):589-603
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399