protein coding gene - SPBC1348.10c - extracellular phospholipase

Gene summary

Systematic ID: SPBC1348.10c
Product: extracellular phospholipase
Organism: Schizosaccharomyces pombe (fission yeast)
Synonyms: SPAC1348.10c
UniProt ID: P0CU03
Characterisation status: biological role inferred
Feature type: mRNA gene
Genomic location: chromosome II: 26155..28372 reverse strand

Annotation

Disease association

MONDO:0018794 - cytosolic phospholipase-A2 alpha deficiency associated bleeding disorder

References:

PB_REF:0000006

GO biological process

GO:0046475 - glycerophospholipid catabolic process

References:

GO_REF:0000033

GO cellular component

GO:0005829 - cytosol

References:

GO_REF:0000033

GO:0005783 - endoplasmic reticulum

References:

GO_REF:0000033

GO:0042597 - periplasmic space

References:

GO_REF:0000024

GO molecular function

GO:0004623 - A2-type glycerophospholipase activity

References:

GO_REF:0000033

GO:0004622 - phosphatidylcholine lysophospholipase A1 activity

References:

GO_REF:0000116

Genome organisation

PBO:0000066 - telomeric duplication

Modification

MOD:00006 - N-glycosylated residue

References:

PMID:36408920

Protein sequence feature

SO:0000418 - signal_peptide

References:

PMID:36408920

Quantitative gene expression

PBO:0011963 - RNA level

References:

PMID:23101633

Single locus phenotype

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

SPBC1348.10cdelta

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

PMID:23697806

Genotypes:

SPBC1348.10cdelta

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

Protein features

ID	Name	InterPro name	DB name
PF01735	PLA2_B	LysoPLipase_cat_dom	Pfam
cd07203	cPLA2_Fungal_PLB		CDD
PS51210	PLA2C	LysoPLipase_cat_dom	PROSITE profiles
SM00022	PLAc	LysoPLipase_cat_dom	SMART
G3DSA:3.40.1090.10:FF:000010			CATH-FunFam
G3DSA:3.40.1090.10			CATH-Gene3D
SSF52151		Acyl_Trfase/lysoPLipase	SUPERFAMILY
PTHR10728			PANTHER
Signal Peptide			DeepTMHMM-Signal-Peptide
mobidb-lite-Disorder	disorder_prediction		MobiDB-Disorder

Orthologs

PLA2G4E (HGNC:24791) Homo sapiens
PLA2G4F (HGNC:27396) Homo sapiens
PLA2G4D (HGNC:30038) Homo sapiens
PLA2G4A (HGNC:9035) Homo sapiens
PLA2G4B (HGNC:9036) Homo sapiens
PLA2G4C (HGNC:9037) Homo sapiens
SJAG_02093 Schizosaccharomyces japonicus
PLB2 (YMR006C) Saccharomyces cerevisiae
PLB1 (YMR008C) Saccharomyces cerevisiae
PLB3 (YOL011W) Saccharomyces cerevisiae

References / Literature

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.: Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.: Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
GO_REF:0000116 - Automatic Gene Ontology annotation based on Rhea mapping.
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:26896847 - Ensembl comparative genomics resources.: Herrero J et al. Database (Oxford) 2016;2016
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.: UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.: Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.