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protein coding gene - SPBC1348.12 - DNA-binding transcription factor

Gene summary

Systematic ID
SPBC1348.12
Product
DNA-binding transcription factor
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
SPAC1348.12
UniProt ID
G2TRT1
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome II: 35112..36589 forward strand

Annotation

GO biological process

GO:0045944 - positive regulation of transcription by RNA polymerase II

References:

GO cellular component

GO:0005634 - nucleus

References:

GO molecular function

GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific

References:

GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding

References:

GO:0008270 - zinc ion binding

References:

Protein features

PBO:0111743 - zinc finger protein

Qualitative gene expression

PomGeneEx:0000011 - RNA level increased

References:

PomGeneEx:0000028 - RNA level increased during Core Environmental Stress Response

References:

Quantitative gene expression

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0006680 - sensitive to bisphenol A

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

Warnings

PBO:0003022 - forced sequence to give coding product

PBO:0000214 - gene structure may be incorrect

PBO:0000070 - gene structure updated

PBO:0001898 - possible frameshift

PBO:0000145 - previously annotated as pseudogene

Protein features

IDNameInterPro nameDB name
PF00172Zn_clusZn2Cys6_DnaBDPfam
cd00067GAL4Zn2Cys6_DnaBDCDD
cd12148fungal_TF_MHRCDD
PS00463ZN2_CY6_FUNGAL_1Zn2Cys6_DnaBDPROSITE patterns
PS50048ZN2_CY6_FUNGAL_2Zn2Cys6_DnaBDPROSITE profiles
SM00066GAL4Zn2Cys6_DnaBDSMART
G3DSA:4.10.240.10Zn2-C6_fun-type_DNA-bd_sfCATH-Gene3D
SSF57701Zn2-C6_fun-type_DNA-bd_sfSUPERFAMILY
PTHR31779Metabolite_Synth_RegPANTHER

Orthologs

References / Literature

PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.
Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
PMID:12529438 - Global transcriptional responses of fission yeast to environmental stress.
Chen D et al. Mol Biol Cell 2003 Jan;14(1):214-29
GO_REF:0000002 - Comments
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;
GO_REF:0000050 - Manual transfer of GO annotation data to genes by curator judgment of sequence model
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:29432178 - General amino acid control in fission yeast is regulated by a nonconserved transcription factor, with functions analogous to Gcn4/Atf4.
Duncan CDS et al. Proc Natl Acad Sci U S A 2018 Feb 20;115(8):E1829-E1838
PMID:36794724 - Cellular responses to long-term phosphate starvation of fission yeast: Maf1 determines fate choice between quiescence and death associated with aberrant tRNA biogenesis.
Garg A et al. Nucleic Acids Res 2023 Apr 24;51(7):3094-3115
PMID:41974504 - Nuclear basket subunits Nup211 and Rsm1 influence RNA 3'-processing and transcription termination in fission yeast.
Bednor L et al. RNA 2026 Apr 13;
PMID:30647105 - Comparative Genomic Screen in Two Yeasts Reveals Conserved Pathways in the Response Network to Phenol Stress.
Alhoch B et al. G3 (Bethesda) 2019 Mar 07;9(3):639-650
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:39833200 - Centromere positioning orchestrates telomere bouquet formation and the initiation of meiotic differentiation.
Jiménez-Martín A et al. Nat Commun 2025 Jan 20;16(1):837