protein coding gene - SPBC1348.12 - DNA-binding transcription factor

Gene summary

Systematic ID: SPBC1348.12
Product: DNA-binding transcription factor
Organism: Schizosaccharomyces pombe (fission yeast)
Synonyms: SPAC1348.12
UniProt ID: G2TRT1
Characterisation status: biological role inferred
Feature type: mRNA gene
Genomic location: chromosome II: 35112..36589 forward strand

Annotation

GO biological process

GO:0045944 - positive regulation of transcription by RNA polymerase II

References:

GO_REF:0000050

GO cellular component

GO:0005634 - nucleus

References:

GO_REF:0000111

GO molecular function

GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific

References:

GO_REF:0000002

GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding

References:

GO_REF:0000050

GO:0008270 - zinc ion binding

References:

GO_REF:0000002

Protein features

PBO:0111743 - zinc finger protein

Qualitative gene expression

PomGeneEx:0000011 - RNA level increased

References:

Quantitative gene expression

PBO:0011963 - RNA level

References:

PMID:23101633

Single locus phenotype

FYPO:0006680 - sensitive to bisphenol A

References:

PMID:30647105

Genotypes:

SPBC1348.12delta

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

Warnings

PBO:0003022 - forced sequence to give coding product

PBO:0000214 - gene structure may be incorrect

PBO:0000070 - gene structure updated

PBO:0001898 - possible frameshift

PBO:0000145 - previously annotated as pseudogene

Protein features

ID	Name	InterPro name	DB name
PF00172	Zn_clus	Zn2Cys6_DnaBD	PFAM
cd12148	fungal_TF_MHR		CDD
cd00067	GAL4	Zn2Cys6_DnaBD	CDD
PS00463	ZN2_CY6_FUNGAL_1	Zn2Cys6_DnaBD	PROSITE_PATTERNS
PS50048	ZN2_CY6_FUNGAL_2	Zn2Cys6_DnaBD	PROSITE_PROFILES
SM00066	gal4_2	Zn2Cys6_DnaBD	SMART
SSF57701	Zn2/Cys6 DNA-binding domain	Zn2-C6_fun-type_DNA-bd_sf	SUPERFAMILY
G3DSA:4.10.240.10		Zn2-C6_fun-type_DNA-bd_sf	GENE3D
PTHR31779	2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17430)-RELATED	Metabolite_Synth_Reg	PANTHER

Orthologs

RDR1 (YOR380W) Saccharomyces cerevisiae

References / Literature

GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:30647105 - Comparative Genomic Screen in Two Yeasts Reveals Conserved Pathways in the Response Network to Phenol Stress.: Alhoch B et al. G3 (Bethesda) 2019 Mar 07;9(3):639-650
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.: Skribbe M et al. Mol Cell 2025 Feb 19;
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.: Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
GO_REF:0000002 - Comments
PMID:36794724 - Cellular responses to long-term phosphate starvation of fission yeast: Maf1 determines fate choice between quiescence and death associated with aberrant tRNA biogenesis.: Garg A et al. Nucleic Acids Res 2023 Apr 24;51(7):3094-3115
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.: Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:29432178 - General amino acid control in fission yeast is regulated by a nonconserved transcription factor, with functions analogous to Gcn4/Atf4.: Duncan CDS et al. Proc Natl Acad Sci U S A 2018 Feb 20;115(8):E1829-E1838
GO_REF:0000050 - Manual transfer of GO annotation data to genes by curator judgment of sequence model
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83