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protein coding gene - gpi14 (SPBC13E7.05) - pig-M, dol-P-Man:GlcN-acyl-PI alpha-1,4-mannosyltransferase

Gene summary

Standard name
gpi14
Systematic ID
SPBC13E7.05
Product
pig-M, dol-P-Man:GlcN-acyl-PI alpha-1,4-mannosyltransferase
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q9P6R5
ORFeome ID
46/46H09
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome II: 3047901..3050504 forward strand

Annotation

Disease association

MONDO:0012465 - hypercoagulability syndrome due to glycosylphosphatidylinositol deficiency

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GO biological process

GO:0006506 - GPI anchor biosynthetic process

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GO cellular component

GO:0005783 - endoplasmic reticulum

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GO:0005789 - endoplasmic reticulum membrane

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GO:1990529 - glycosylphosphatidylinositol-mannosyltransferase I complex

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GO molecular function

GO:0180041 - dol-P-Man:GlcN-acyl-PI alpha-1,4-mannosyltransferase activity

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Protein sequence feature

SO:0001812 - transmembrane_helix

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Qualitative gene expression

PomGeneEx:0000018 - protein level increased

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PomGeneEx:0000012 - RNA level decreased

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PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0001042 - inviable after spore germination, single or double cell division

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Genotypes:

FYPO:0000313 - inviable after spore germination, without cell division, with abnormal germ tube morphology

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Warnings

PBO:0000214 - gene structure may be incorrect

Protein features

IDNameInterPro nameDB name
PF05007Mannosyl_transPIG-MPfam
PTHR12886PIG-MPANTHER
Transmembrane alpha helixDeepTMHMM

Orthologs

References / Literature

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.
Mata J et al. Nat Genet 2002 Sep;32(1):143-7
PMID:15635094 - Mammalian PIG-X and yeast Pbn1p are the essential components of glycosylphosphatidylinositol-mannosyltransferase I.
Ashida H et al. Mol Biol Cell 2005 Mar;16(3):1439-48
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83